EMBRACE - From Vulnerable to Empowered: Implementation and Evaluation of a Multicomponent Program to Tackling Age-related Decline (EMBRACE)
2026년 6월 2일 업데이트: Carina Fernandes, University Fernando Pessoa
EMBRACE is a randomized, controlled, multi-domain, blinded clinical trial involving 120 community-dwelling older adults at risk of cognitive decline, lasting 12 months.
Participants are randomized 1:1 to either a multicomponent intervention group, including cognitive and language training, physical activity, nutritional counseling with oral health support, and financial and digital literacy education, or to a control group receiving regular health counseling.
The trial evaluates the effects of the intervention on cognitive performance, quality of life, functionality, financial literacy, digital inclusion, and other health-related outcomes.
연구 개요
상세 설명
The EMBRACE program is a research initiative designed to address the increasing challenges of aging, particularly the risk of cognitive decline and dementia, vulnerability to economic fraud, and digital exclusion. The EMBRACE intervention is a multicomponent, non-pharmacological approach that includes cognitive training, linguistic stimulation, physical activity guidance, nutritional counseling, and education on financial and digital literacy. Through a carefully designed randomized controlled trial, this research project aims to evaluate the effectiveness of the EMBRACE program in improving the quality of life, functionality, and overall well-being of older adults.
By combining various aspects of health and well-being, the project aligns with the emphasis of the World Health Organization (WHO) on developing and implementing preventive strategies to reduce the risk of dementia. The innovative aspect of integrating financial and digital literacy education into the intervention recognizes the evolving challenges faced by the aging population, who are among the primary victims of economic fraud and particularly vulnerable to digital exclusion.
The primary beneficiaries of the EMBRACE program will be older adults who are at risk of developing cognitive decline or dementia. By equipping participants with tools and strategies to maintain cognitive health and physical well-being, the project aims to enhance quality of life. Moreover, the program's findings could inform public health policies and eldercare practices, potentially benefiting a broader spectrum of older adults by promoting strategies for active and healthy aging. In addition to direct participants, the project's outcomes are expected to benefit healthcare professionals, caregivers, and policymakers by providing validated approaches to prevent or delay cognitive decline among older adults. Furthermore, if the EMBRACE program proves successful, the investigators plan to integrate it into the curriculum of national senior universities and adapt it for digital platforms. This would enable global dissemination, extending its benefits to a broader audience worldwide.
연구 유형
중재적
등록 (추정된)
120
단계
- 해당 없음
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 장소
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Porto District
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Porto, Porto District, 포르투갈, 4249-004
- University Fernando Pessoa
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연락하다:
- Carina Fernandes
- 전화번호: +351 915101426
- 이메일: carinafernandes@ufp.edu.pt
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
예
설명
Inclusion Criteria:
- MoCA ≥ 17 (Portuguese cutoff point to differentiate between mild cognitive impairment and dementia);
- Bedside ≥ 20 for literate individuals or 12 for illiterate individuals.
Exclusion Criteria:
- Malignant diseases;
- Diagnosed major depressive disorder;
- Dementia/substantial cognitive decline (MoCA < 17);
- Symptomatic cardiovascular disease;
- Revascularization within the last year;
- Active malignancy;
- Severe loss of vision, hearing, or communication;
- Contraindications for physical activity;
- Neuromuscular diseases;
- Severe musculoskeletal pathology;
- Inability to walk independently;
- Neurological disease affecting language functions;
- Simultaneous participation in any intervention trial.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 방지
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 하나의
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: Experimental Group
60 participants in the experimental group (EG) will receive an intensive multicomponent intervention consisting of nutrition and oral medicine; physical activity; cognitive training (or compensation in those cases in which participants revealed mild cognitive impairment at the baseline assessment); and financial and digital literacy education.
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This intervention will last 12 months and will consist of four components.
The nutritional intervention includes 5 individual sessions (at the beginning of the study and at 3, 6, 9, and 12 months) and 12 group sessions (1 per month) based on the Mediterranean diet, with support for oral health.
Financial and digital literacy will be addressed in monthly sessions, covering topics such as retirement, investments, and fraud prevention.
Cognitive and linguistic training will take place twice a week (80 sessions), with activities adapted through the COGWEB platform and support from a speech therapist.
Physical training will also be conducted twice a week, including aerobic exercise, strength training, balance training, and dual-task training, with intensity adjusted using the Borg scale.
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간섭 없음: Control Group
60 participants in the control group will not undergo the EMBRACE intervention; they will only receive regular health advice.
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Montreal Cognitive Assessment (MoCA)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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General cognitive functions will be assessed using the MoCA.
The MoCA is a cognitive screening instrument used to evaluate multiple cognitive domains, with scores ranging from 0 to 30, where higher scores indicate better cognitive performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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World Health Organization Quality of Life - Brief Version (WHOQOL-BREF)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Quality of life will be assessed using the WHOQOL-BREF.
The WHOQOL-BREF is a questionnaire used to evaluate quality of life across physical, psychological, social relationships, and environmental domains, with scores ranging from 0 to 100, where higher scores indicate better quality of life.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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d2 Test
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Selective attention and concentration ability will be assessed using the d2 Test.
The d2 Test is a neuropsychological instrument used to evaluate selective attention, concentration, and processing speed through a timed cancellation task consisting of 14 lines to be completed in a maximum of 20 seconds per line.
Performance is measured through task execution indices, concentration, processing speed, and error percentage.
Higher scores on task execution and concentration indices, and lower error percentages, indicate better attentional performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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INECO Frontal Screening (IFS)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Executive functions will be assessed using the IFS.
The IFS is a cognitive screening instrument used to evaluate executive functioning, including inhibitory control, cognitive flexibility, working memory, and abstraction ability, with scores ranging from 0 to 30, where higher scores indicate better executive functioning.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Stroop Test
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Inhibitory control, cognitive flexibility, and resistance to interference will be assessed using the Stroop Test.
The Stroop Test consists of three tasks (word, color, and color-word), each administered within a maximum time of 45 seconds.
Performance is measured by the number of words, colors, and stimuli correctly identified, where higher scores indicate better cognitive performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Trail Making Test (TMT)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Alternating attention, visual attention, and processing speed will be assessed using the TMT.
The TMT is a neuropsychological instrument used to evaluate visual attention, alternating attention, and processing speed through a timed task requiring participants to connect a sequence of numbers and letters.
Performance is measured by completion time in seconds, where shorter completion times indicate better cognitive performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Spatial Span Subtest of the Wechsler Memory Scale - Third Edition (WMS-III)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Working memory will be assessed using the Spatial Span Subtest of the WMS-III.
The Spatial Span Subtest is a neuropsychological instrument used to evaluate visuospatial working memory through forward and backward span tasks, with scores ranging from 0 to 32, where higher scores indicate better working memory performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Logical Memory Subtest of the Wechsler Memory Scale - Third Edition (WMS-III)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Immediate and delayed verbal episodic memory will be assessed using the Logical Memory Subtest of the WMS-III.
The Logical Memory Subtest is a neuropsychological instrument used to evaluate the recall and recognition of verbally presented information, with scores ranging from 0 to 75 for immediate recall, 0 to 30 for delayed recall, and 0 to 30 for recognition, where higher scores indicate better memory performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Rey Auditory Verbal Learning Test (RAVLT)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Verbal learning and memory will be assessed using the RAVLT.
The RAVLT is a neuropsychological instrument used to evaluate verbal learning, immediate recall, delayed recall, and recognition memory through repeated presentation of a 15-word list.
Performance is measured by the number of correctly recalled or recognized words across the assessment trials, where higher scores indicate better verbal learning and memory performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Boston Naming Test (BNT)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Naming ability will be assessed using the BNT.
The BNT is a neuropsychological instrument used to evaluate confrontation naming ability through the identification of visually presented objects, with scores ranging from 0 to 60, where higher scores indicate better naming performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Phonemic and Semantic Verbal Fluency Tests
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Verbal fluency and executive functions will be assessed through Phonemic and Semantic Verbal Fluency Tests.
These neuropsychological tests are used to evaluate information retrieval from memory, executive functions (such as cognitive flexibility, planning, and inhibitory control), and language production through word generation within a maximum time frame of 1 minute for each task, where higher scores indicate better performance in verbal fluency.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Instrumental Activities of Daily Living (IADL)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Functionality in instrumental activities of daily living will be assessed using the IADL scale.
The IADL scale is used to evaluate independence in everyday functional activities, with scores ranging from 8 to 31, where lower scores indicate greater functional independence.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Hospital Anxiety and Depression Scale (HADS)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Symptoms of anxiety and depression will be assessed using the HADS.
The HADS is a self-report questionnaire used to evaluate symptoms of anxiety and depression, with scores ranging from 0 to 21 for each subscale, where higher scores indicate greater symptom severity.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Numerical Activities of Daily Living - Financial (NADL-F)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Financial literacy and functionality in numerical activities of daily living will be assessed using the NADL-F assessment.
The NADL-F is used to evaluate financial abilities and numerical functioning in everyday activities across domains including money counting (scores ranging from 0 to 5), reading abilities (0 to 8), purchasing articles (0 to 14), percentages (0 to 9), financial concepts (0 to 14), bill payment (0 to 6), and financial judgment (0 to 6), where higher scores indicate better financial functioning and autonomy in daily life.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Bedside Language Test
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Language abilities will be assessed using the Bedside Language Test.
The Bedside Language Test is a language assessment tool used to evaluate speech, language comprehension, repetition, reading, and writing abilities, with scores ranging from 0 to 25, where higher scores indicate better language performance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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PREDIMED
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Adherence to the Mediterranean diet will be assessed using the PREDIMED questionnaire.
The PREDIMED questionnaire is used to evaluate adherence to Mediterranean dietary patterns, with scores ranging from 0 to 14, where higher scores indicate greater adherence to the Mediterranean diet.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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International Physical Activity Questionnaire (IPAQ)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Physical activity level will be assessed using the IPAQ.
The IPAQ is used to evaluate the frequency, duration, and intensity of physical activity performed in daily life.
Physical activity levels are calculated in MET-minutes per week based on the frequency and duration of walking and moderate- and vigorous-intensity activities, with higher scores indicating higher levels of physical activity.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Timed Up and Go Test (TUG)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Functional mobility and dynamic balance ability will be assessed using the TUG.
The TUG is used to evaluate functional mobility and dynamic balance through the time required to stand up from a chair, walk a short distance, return, and sit down, with performance measured in seconds, where shorter completion times indicate better functional mobility and balance.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Blood Pressure
기간: Baseline, post-intervention (12 months), and 6-month follow-up
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Systolic and diastolic blood pressure will be measured in millimeters of mercury (mmHg).
Scores range from approximately (for diastolic) 60-120 and (for systolic) 100-180 mmHg, with higher scores indicating higher blood pressure.
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Baseline, post-intervention (12 months), and 6-month follow-up
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Body Mass Index (BMI)
기간: Baseline, post-intervention (12 months), and 6-month follow-up
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Body mass index (BMI) will be calculated using body weight and height and expressed in kilograms per square meter (kg/m²).
BMI is a measure of body size based on weight relative to height.
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Baseline, post-intervention (12 months), and 6-month follow-up
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Handgrip Strength
기간: Baseline, post-intervention (12 months), and 6-month follow-up
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Handgrip strength will be assessed using a hand dynamometer.
Performance is measured in kilograms-force (kgf), where higher values indicate greater muscular strength.
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Baseline, post-intervention (12 months), and 6-month follow-up
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Blood Count
기간: Baseline, post-intervention (12 months), and 6-month follow-up
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Hematological status will be assessed using a blood count performed through blood analysis.
Results will be reported according to standard laboratory reference units.
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Baseline, post-intervention (12 months), and 6-month follow-up
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Serum Magnesium
기간: Baseline, post-intervention (12 months), and 6-month follow-up
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Serum magnesium levels will be assessed through blood analysis and reported according to standard laboratory reference units.
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Baseline, post-intervention (12 months), and 6-month follow-up
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Serum Iron
기간: Baseline, post-intervention (12 months), and 6-month follow-up
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Serum iron levels will be assessed through blood analysis and reported according to standard laboratory reference units.
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Baseline, post-intervention (12 months), and 6-month follow-up
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Vitamin B12
기간: Baseline, post-intervention (12 months), and 6-month follow-up
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Vitamin B12 levels will be assessed through blood analysis and reported according to standard laboratory reference units.
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Baseline, post-intervention (12 months), and 6-month follow-up
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Decayed, Missing, and Filled Teeth Index (CPO-D)
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Oral health status will be assessed using the Decayed, Missing, and Filled Teeth Index (CPO-D).
The CPO-D index is used to evaluate oral health status based on the number of decayed, missing, and filled teeth, where higher scores indicate poorer oral health status.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Salivary pH Analysis
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Salivary condition and oral health status will be assessed using salivary pH analysis.
Salivary pH values will be measured to evaluate salivary condition and oral health status, and will be reported according to standard pH units.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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Dental Prosthesis Status
기간: Baseline, post-intervention (12 months), and 6-month follow-up.
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Dental prosthesis status will be assessed through clinical oral examination.
The assessment will evaluate the presence, type, functional status, and need for adjustment or replacement of dental prostheses.
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Baseline, post-intervention (12 months), and 6-month follow-up.
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공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Ngandu T, Lehtisalo J, Solomon A, Levalahti E, Ahtiluoto S, Antikainen R, Backman L, Hanninen T, Jula A, Laatikainen T, Lindstrom J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Jun 6;385(9984):2255-63. doi: 10.1016/S0140-6736(15)60461-5. Epub 2015 Mar 12.
- Pais-Ribeiro J, Silva I, Ferreira T, Martins A, Meneses R, Baltar M. Validation study of a Portuguese version of the Hospital Anxiety and Depression Scale. Psychol Health Med. 2007 Mar;12(2):225-35; quiz 235-7. doi: 10.1080/13548500500524088. English, Portuguese.
- Vaz Serra et al. (2006). Estudos psicométricos do instrumento de avaliação da qualidade de vida da Organização Mundial de Saúde (WHOQOL-Bref) para português de Portugal. Psiquiatria Clínica, 27(1), 41-49
- Araújo et al. (2008). Validação da escala de Lawton e Brody numa amostra de idosos não institucionalizados. In I. Pais-Ribeiro et al. (Eds.), Actas do 7º Congresso Nacional de Psicologia da Saúde (pp. 217-220). ISPA.
- Cruz & Pais (2012). Cogweb-sistema integrado de estimulação cognitiva: Manual de formação para profissionais. Gaia: Neuroinova.
- Fernandes C, Pasion R, Goncalves AR, Ferreira-Santos F, Barbosa F, Martins IP, Marques-Teixeira J. Age differences in neural correlates of feedback processing after economic decisions under risk. Neurobiol Aging. 2018 May;65:51-59. doi: 10.1016/j.neurobiolaging.2018.01.003. Epub 2018 Jan 17.
- Kibby MY, Schmitter-Edgecombe M, Long CJ. Ecological validity of neuropsychological tests: focus on the California Verbal Learning Test and the Wisconsin Card Sorting Test. Arch Clin Neuropsychol. 1998 Aug;13(6):523-34.
- Williams, N. 2017. The Borg Rating of Perceived Exertion (RPE) scale. Occupational Medicine, 67 (5), 404-5.
- Tavares J, Faria A, Goncalves D, Mendes D, Silva S, Sousa L. Validation of the Portuguese version of the social isolation scale with a sample of community-dwelling older adults. Int J Nurs Sci. 2023 Mar 10;10(2):151-157. doi: 10.1016/j.ijnss.2023.03.002. eCollection 2023 Apr.
- Wei, L., Peng, M., & Wu, W. 2021. Financial literacy and fraud detection--Evidence from China. International Review of Economics & Finance, 76, 478-94.
- Fernandes, C., Macedo, I., Gonçalves, A. R., Pasion, R., Mata, R., Danese, G., Martins, I. P., Barbosa, F., & Marques-Teixeira, J. 2022. Neurophysiological examination of the Affect-Integration-Motivation framework of decision-making in the aging brain: A registered report Author links open overlay panel. NeuroImage, 256.
- Fernandes C, Macedo I, Barbosa F, Marques-Teixeira J. Economic decision-making in the continuum between healthy aging and Alzheimer's Disease: A systematic review of 20 years of research. Neurosci Biobehav Rev. 2021 Dec;131:1243-1263. doi: 10.1016/j.neubiorev.2021.10.030. Epub 2021 Oct 29.
- Martinez-Gonzalez MA, Salas-Salvado J, Estruch R, Corella D, Fito M, Ros E; PREDIMED INVESTIGATORS. Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Prog Cardiovasc Dis. 2015 Jul-Aug;58(1):50-60. doi: 10.1016/j.pcad.2015.04.003. Epub 2015 May 1.
- Bauman A, Ainsworth BE, Sallis JF, Hagstromer M, Craig CL, Bull FC, Pratt M, Venugopal K, Chau J, Sjostrom M; IPS Group. The descriptive epidemiology of sitting. A 20-country comparison using the International Physical Activity Questionnaire (IPAQ). Am J Prev Med. 2011 Aug;41(2):228-35. doi: 10.1016/j.amepre.2011.05.003.
- Rolland Y, Abellan van Kan G, Nourhashemi F, Andrieu S, Cantet C, Guyonnet-Gillette S, Vellas B. An abnormal "one-leg balance" test predicts cognitive decline during Alzheimer's disease. J Alzheimers Dis. 2009;16(3):525-31. doi: 10.3233/JAD-2009-0987.
- Benavent-Caballer V, Sendin-Magdalena A, Lison JF, Rosado-Calatayud P, Amer-Cuenca JJ, Salvador-Coloma P, Segura-Orti E. Physical factors underlying the Timed "Up and Go" test in older adults. Geriatr Nurs. 2016 Mar-Apr;37(2):122-7. doi: 10.1016/j.gerinurse.2015.11.002. Epub 2015 Dec 17.
- Langhammer B, Stanghelle JK. The Senior Fitness Test. J Physiother. 2015 Jul;61(3):163. doi: 10.1016/j.jphys.2015.04.001. Epub 2015 Jun 1. No abstract available.
- Cavaco S, Goncalves A, Pinto C, Almeida E, Gomes F, Moreira I, Fernandes J, Teixeira-Pinto A. Semantic fluency and phonemic fluency: regression-based norms for the Portuguese population. Arch Clin Neuropsychol. 2013 May;28(3):262-71. doi: 10.1093/arclin/act001. Epub 2013 Jan 21.
- Cavaco S, Goncalves A, Pinto C, Almeida E, Gomes F, Moreira I, Fernandes J, Teixeira-Pinto A. Trail Making Test: regression-based norms for the Portuguese population. Arch Clin Neuropsychol. 2013 Mar;28(2):189-98. doi: 10.1093/arclin/acs115. Epub 2013 Jan 7.
- Sur A, DeLiema M, Vock DM, Boyle P, Yu L. A Microsimulation of Well-Being and Literacy Interventions to Reduce Scam Susceptibility in Older Adults. J Appl Gerontol. 2023 Dec;42(12):2360-2370. doi: 10.1177/07334648231196850. Epub 2023 Sep 13.
- Bates ME, Lemay EP Jr. The d2 Test of attention: construct validity and extensions in scoring techniques. J Int Neuropsychol Soc. 2004 May;10(3):392-400. doi: 10.1017/S135561770410307X.
- DeLiema M, Deevy M, Lusardi A, Mitchell OS. Financial Fraud Among Older Americans: Evidence and Implications. J Gerontol B Psychol Sci Soc Sci. 2020 Mar 9;75(4):861-868. doi: 10.1093/geronb/gby151.
- Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, Browndyke JN, Sherwood A. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010 Apr;72(3):239-52. doi: 10.1097/PSY.0b013e3181d14633. Epub 2010 Mar 11.
- Roig M, Nordbrandt S, Geertsen SS, Nielsen JB. The effects of cardiovascular exercise on human memory: a review with meta-analysis. Neurosci Biobehav Rev. 2013 Sep;37(8):1645-66. doi: 10.1016/j.neubiorev.2013.06.012. Epub 2013 Jun 24.
- Nucci D, Sommariva A, Degoni LM, Gallo G, Mancarella M, Natarelli F, Savoia A, Catalini A, Ferranti R, Pregliasco FE, Castaldi S, Gianfredi V. Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis. Aging Clin Exp Res. 2024 Mar 22;36(1):77. doi: 10.1007/s40520-024-02718-6.
- Lampit A, Hallock H, Valenzuela M. Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. PLoS Med. 2014 Nov 18;11(11):e1001756. doi: 10.1371/journal.pmed.1001756. eCollection 2014 Nov.
- Karssemeijer EGA, Aaronson JA, Bossers WJ, Smits T, Olde Rikkert MGM, Kessels RPC. Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis. Ageing Res Rev. 2017 Nov;40:75-83. doi: 10.1016/j.arr.2017.09.003. Epub 2017 Sep 12.
- Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003 Mar;14(2):125-30. doi: 10.1111/1467-9280.t01-1-01430.
- Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol. 2006 Sep;5(9):735-41. doi: 10.1016/S1474-4422(06)70537-3.
- Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 2014 Aug;13(8):788-94. doi: 10.1016/S1474-4422(14)70136-X.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (추정된)
2026년 6월 1일
기본 완료 (추정된)
2028년 5월 31일
연구 완료 (추정된)
2029년 5월 31일
연구 등록 날짜
최초 제출
2026년 5월 12일
QC 기준을 충족하는 최초 제출
2026년 6월 2일
처음 게시됨 (실제)
2026년 6월 5일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2026년 6월 5일
QC 기준을 충족하는 마지막 업데이트 제출
2026년 6월 2일
마지막으로 확인됨
2026년 6월 1일
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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