British University College is Learning MRI and Histology Image Mappings for Cancer Diagnosis and Prognosis
University College, London is starting a new clinical trial of Learning MRI and Histology Image Mappings for Cancer Diagnosis and Prognosis.
Multiparametric magnetic resonance imaging (mpMRI) is now widely used to risk stratify men with a suspicion of prostate cancer and identify suspicious regions for biopsy. Advanced MRI techniques have emerged which seek to improve this characterisation and could predict biopsy results non-invasively before men undergo biopsy. Before these techniques are translated clinically, robust histological and clinical validation is required.
This study aims to clinically validate advanced MRI techniques in a cohort of men suspected with prostate cancer. Histological analysis of men undergoing biopsy, +/- prostatectomy will be used for biological validation of VERDICT; Vascular and Extracellular Restricted Diffusion for Cytometry in Tumours and Luminal Water imaging (LWI). In particular, prostatectomy specimens will be processed using 3-D printed patient-specific moulds to allow for accurate MRI and histology mapping.
The population that can be enrolled into this study includes cohort of men presenting to our recruitment centre with suspicion of prostate cancer due to raised prostate specific antigen level or suspicious clinical examination.
The clinical trial started in October 23, 2020 and will continue throughout October 2023.
Diagnostic accuracy of VERDICT MRI will be primary outcome measure. Quantitative assessment of VERDICT MRI reduces false positives by 10% compared to standard MRI alone.
Among the exclusion criteria are:
- Men unable to have a MRI scan, or in whom artefact would reduce quality of MRI
- Men unable to given informed consent
- Previous treatment (prostatectomy, radiotherapy, brachytherapy) of prostate cancer
- Ongoing hormonal treatment for prostate cancer
The contacts and locations are the University College London Hospital, London, United Kingdom.
University College London, officially known as UCL since 2005, is a public research university located in London, United Kingdom, and a member institution of the federal University of London. It is the largest university in the United Kingdom by total enrolment apart from the Open University, and the largest by postgraduate enrolment.
UCL operates a number of disciplinary-specific research centres in partnership with other research institutions and private enterprises.
For more details: https://ichgcp.net/clinical-trials-registry/NCT04792138
