Clinical trial for patients with Cognitive Function Evaluation and Rehabilitation by a Digital Game: MentalPlus®

The company University of Sao Paulo is commencing recruitment for the clinical trial of the Cognitive Function Evaluation and Rehabilitation by a Digital Game: MentalPlus®.

The condition is Neuropsychological Test.

A new clinical trial is recruiting patients in the following locations: Brazil.

The trial officially began on the July 8, 2020 and is planned to complete on November 29, 2023.

Cognitive dysfunction is a frequent adverse event in the postoperative period, especially in elderly patients. The tests commonly used for the detection of postoperative cognitive dysfunction (POCD) are time-consuming what limits their routine use. Consequently; there is a limitation to adopt measures to increase preoperative cognitive reserve and rehabilitation of POCD. That situation is an incentive to search for alternative diagnosis methods to overcome that limitation. Digital games have potential neuromodulator effect and have been used as an alternative to the psychotherapeutic treatment and rehabilitation of cognitive skills. However, the experience with these games to assess the integrity of perioperative neuropsychological functions is still scarce. It is hypothesized that a digital game could replace the usual neuropsychological tests for detecting POCD. The aim of this study is to validate a specific digital game, MentalPlus®, for cognitive assessment and POCD evaluation and for POCD rehabilitation.

The population that can be enrolled into this study includes:

  • Individuals who accept the invitation will be first submitted to the TICS Instrument (Telephone Interview Cognitive Status), which aims to verify the global cognitive status of the subject evaluated. Will be included subjects with TICS score >25. Exclusion Criteria: - Patients who do not meet the TICS inclusion criteria will be excluded at this stage and informed that they did not fulfill all the requirements for the study.

Patients with the following pathologies:

  • Patients who do not meet the TICS inclusion criteria will be excluded at this stage and informed that they did not fulfill all the requirements for the study.

are excluded from participation.

University of Copenhagen, Max Planck Institute for Human Development, Karolinska Institutet, The Cleveland Clinic, University of California, Los Angeles, UMC Utrecht, Harvard Medical School, Keio University, California Institute of Technology are the collaborators in this clinical trial.

The link to the complete study profile:

https://ichgcp.net/clinical-trials-registry/NCT04637191

 

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