Danish Hospital is developing Individualized Treatment Strategy for Patients With Metastatic Non-clear Cell Renal Cell Carcinoma

Herlev and Gentofte Hospital is enrolling patients into the clinical trial investigating Individualized Treatment Strategy for Patients With Metastatic Non-clear Cell Renal Cell Carcinoma (INDIGO).

The purpose of the open-label INDIGO-study is to examine whether a first line individualized treatment strategy based on DNA and RNA analyses from the patient's tumor is feasible. Moreover, to involve the patient further in their treatment via patient-reported outcomes (PRO) measurements in a value-based healthcare setup with simultaneous analyses of the financial costs of this strategy.

Among the criteria that do not allow participation, the following are indicated:

• Previous systemic treatment for metastatic RCC (including neoadjuvant treatment).
• Former adjuvant treatment with immune checkpoint inhibitors.
• Major surgical procedure, open surgical biopsy or significant trauma within 28 days prior to initiation.
• Serious non-healing wound, ulcer or bone fracture.
• Auto-immune disease or other condition requiring systemic treatment with either corticosteroids or other immunosuppressive drugs.

There are other exclusion criteria.

Gentofte Hospital (Copenhagen University Hospital Gentofte) is located in Gentofte within Copenhagen in Denmark. Administratively, it is part of the hospital service of Region Hovedstaden.
As one of the university hospitals for Copenhagen University (the hospital is also a teaching hospital for medical students from the university), the hospital has extensive research and training facilities. Two large medical departments cover gastroenterology, endocrinology, rheumatology, geriatric medicine and stroke rehabilitation. It also houses dedicated cardiology and pulmonary medicine departments, an ENT department with the largest audiology department in Denmark and a dermatology and allergy unit. The hospital also hosts the regional department for innovations in elective surgery. Additionally, Gentofte Hospital has both a closed and open psychiatric ward.

The study will take place in Department of Oncology, Herlev and Gentofte Hospital, Herlev, Denmark, 2730.

This page provides a more detailed overview of this clinical trial: https://ichgcp.net/clinical-trials-registry/NCT04644432