Danish hospital starts a new clinical trial of Carbon Monoxide-based Rebreathing Method and Bioimpedance in Hemodialysis Patients
Photo by Hush Naidoo
The one of the largest hospitals in Denmark, Rigshospitalet is starting a new clinical trial of Carbon Monoxide-based Rebreathing Method and Bioimpedance in Hemodialysis Patients.
The study is a case-control study with the primary aim of objectifying the volume status of patients receiving hemodialysis. Volume status will be assessed at dry weight and evaluated by a carbon monoxide rebreathing method, that measures blood volume, and bioimpedance that measures total body water. Case-control subjects will be matched on gender, age and weight.
Secondary aims are to evaluate the carbon monoxide rebreathing method. Blood volumes obtained by the carbon monoxide rebreathing method will be correlated to blood volumes obtained by radioactive labelling of erythrocytes and albumin. In addition, it will be investigated whether hemoglobin is a valid marker of anemia in patients receiving hemodialysis by measuring the erythrocyte volume and the hemoglobin mass by the carbon monoxide rebreathing method and correlating this to the hemoglobin concentration measured before and after dialysis.
The clinical trial started in November 25, 2020 and will continue throughout December 20, 2021.
The primary outcome measure is blood volume by carbon monoxide rebreathing method.
The patients are recruited from the department of Nephrology at Rigshospitalet and Herlev Hospital.
Among the criteria that do not allow participation, the following are indicated:
- Pregnant or breastfeeding.
- Hybrid dialysis (both hemodialysis and peritoneal dialysis simultaneously).
- Chronic obstructive pulmonary disease, asthma or interstitial pulmonary fibrosis.
- Pulmonary embolism within 6 months.
- Lung cancer or previous lung surgery.
The contacts and locations are the Herlev Hospital, Copenhagen and Rigshospitalet, Department of Nephrology, København Ø, Denmark.
Rigshospitalet (meaning The National, State or Kingdom Hospital, but not usually translated) is one of the largest hospitals in Denmark and the most highly specialised hospital in Copenhagen. Rigshospitalet neighbours the Panum Building which houses the Faculty of Health and Medical Sciences at the University of Copenhagen. As a teaching hospital it is part of the framework organisation Copenhagen University Hospital.
For more details: https://ichgcp.net/clinical-trials-registry/NCT04645121
