University hospital center is starting a clinical rial of COVID-19 and Pregnancy: Placental and Immunological Impacts
Photo by Andrea Bertozzini
Hopital Foch is starting a new clinical trial of COVID-19 and Pregnancy: Placental and Immunological Impacts.
The aim of this study is to compare placental pathologies in patients with COVID 19 infection at the time of childbirth or a history of COVID 19 during pregnancy versus control patients.
The second wave of COVID 19 is currently sweeping through Europe. If the first wave brought reassuring elements on the risk of maternal-fetal transmission, it nevertheless counted an increase in severe maternal forms in the third trimester associated with more premature deliveries and cesarean sections. In addition, due to the very recent nature of this new infection, we have little data on the effect of SARS-COV 2 contracted during pregnancy on the fetus and on maternal-fetal exchanges.
Publications report an increase in growth retardation, maternal coagulopathies, preeclampsia and placental thrombosis. The vascular placental abnormalities observed in the first series must be confirmed and refined. Finally, pregnancy is marked by immunomodulation which can interfere with immune reactions. A better understanding of the immunological mechanisms in the mother and of the immunity transmitted to the fetus is necessary to better understand the maternal-fetal issues of COVID 19.
Among the exclusion criteria are:
- Minor (age <18 years, on inclusion)
- Diabetes with and without insulin (only for the control group)
- High blood pressure (only for the control group)
- Preeclampsia (only for the control group)
- Infection during pregnancy: HIV, toxoplasmosis, rubella, CMV, syphilis
- PCR Influenza A or B positive, proven by nasopharyngeal swab in the week preceding childbirth
The Hopital Foch, is a university hospital center located in Suresnes, France founded in 1929. It specializes in pulmonology and neuroscience.
Member of the Établissement de santé privé d'intérêt collectif and of a university hospital of the University of Versailles Saint Quentin en Yvelines, it is one of the largest hospitals in Europe.
The contacts and locations are the Hopital Foch, Suresnes, France. For more details: https://ichgcp.net/clinical-trials-registry/NCT04726111
