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Isometric Exercise for Delayed Onset Muscle Soreness

13 juni 2026 bijgewerkt door: Onur Atakan Sekibağ, Istanbul Nisantasi University

Effects of Isometric Exercise on Recovery Following Experimentally Induced Delayed Onset Muscle Soreness: A Randomized Controlled Trial

The goal of this clinical trial is to learn whether isometric exercise can improve recovery following experimentally induced delayed onset muscle soreness (DOMS) in healthy young adults.

The main questions it aims to answer are:

  • Does isometric exercise reduce pain associated with delayed onset muscle soreness?
  • Does isometric exercise improve pressure pain threshold, knee joint range of motion, muscle strength, and recovery following delayed onset muscle soreness?

Researchers will compare participants performing an isometric exercise program with a control group receiving no intervention to determine whether isometric exercise improves recovery after experimentally induced DOMS.

Participants will:

  • Undergo a standardized exercise protocol to induce delayed onset muscle soreness.
  • Be randomly assigned to either an isometric exercise group or a control group.
  • Complete assessments of pain intensity, pressure pain threshold, knee range of motion, muscle strength, and thigh circumference.
  • Be evaluated before exercise, immediately after exercise, and on Days 1, 3, and 5 following DOMS induction.

Studie Overzicht

Toestand

Voltooid

Conditie

Interventie / Behandeling

Gedetailleerde beschrijving

Delayed onset muscle soreness (DOMS) is a common consequence of unaccustomed or high-intensity physical activity, particularly exercises involving eccentric muscle contractions. DOMS is characterized by pain, tenderness, temporary reductions in muscle function, decreased range of motion, and impaired physical performance, typically peaking between 24 and 72 hours after exercise.

Various recovery strategies have been investigated to reduce the symptoms of DOMS; however, evidence regarding the effectiveness of isometric exercise in facilitating recovery remains limited. Previous studies have suggested that isometric muscle contractions may induce analgesic effects and increase pressure pain thresholds in musculoskeletal conditions. Whether these effects can improve recovery following exercise-induced muscle damage and DOMS has not been fully established.

The purpose of this randomized controlled trial was to investigate the effects of an isometric exercise program on recovery following experimentally induced DOMS in healthy adults. DOMS was induced using a standardized drop-jump protocol. Participants were randomly assigned to either an isometric exercise group or a control group. Outcome assessments were performed before DOMS induction, immediately after exercise, and during follow-up evaluations on Days 1, 3, and 5.

The findings of this study may contribute to the understanding of the role of isometric exercise as a simple, low-cost, and clinically applicable recovery strategy following exercise-induced muscle soreness.

Studietype

Ingrijpend

Inschrijving (Werkelijk)

40

Fase

  • Niet toepasbaar

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

  • Turkije (Türkiye)
    • Maslak
      • Istanbul, Maslak, Turkije (Türkiye), 34398
        • Istanbul Nisantasi University

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

  • Volwassen

Accepteert gezonde vrijwilligers

Ja

Beschrijving

Inclusion Criteria:

  • Active athletes competing in University sports teams.
  • Age between 18 and 30 years.
  • Participation in organized sports training at least three times per week for the previous six months.
  • No lower-extremity pain at the time of enrollment.
  • Ability to safely perform the exercise protocol used to induce delayed onset muscle soreness (DOMS).
  • Willingness to provide written informed consent.

Exclusion Criteria:

  • History of lower-extremity musculoskeletal injury within the previous 6 months.
  • Previous lower-extremity surgery.
  • Current musculoskeletal pain or injury affecting sports participation.
  • Neurological, rheumatological, cardiovascular, or systemic disorders affecting physical performance.
  • Use of analgesic, anti-inflammatory, or muscle-relaxant medications during the study period.
  • Participation in strenuous eccentric exercise within 72 hours prior to baseline testing.
  • Use of recovery interventions (e.g., massage, cryotherapy, compression garments, electrical stimulation) during the study period.
  • Inability to complete the exercise protocol or follow-up assessments.

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Primair doel: Behandeling
  • Toewijzing: Gerandomiseerd
  • Interventioneel model: Parallelle opdracht
  • Masker: Dubbele

Wapens en interventies

Deelnemersgroep / Arm
Interventie / Behandeling
Experimenteel: Isometric Exercise Group
Participants in this group underwent a standardized protocol to induce delayed onset muscle soreness (DOMS) and subsequently performed a structured quadriceps isometric exercise program during the recovery period.
Ander: Isometric Exercise
Participants performed a structured quadriceps isometric exercise program following experimentally induced delayed onset muscle soreness. The exercise protocol was applied according to the study protocol throughout the recovery period.
Sham-vergelijker: Sham Exercise Group
Participants performed a sham exercise protocol following experimentally induced delayed onset muscle soreness. The sham intervention was designed to mimic the attention and participation associated with the experimental intervention without providing the intended therapeutic effect.
Ander: Sham Exercise
Participants performed a sham exercise protocol following experimentally induced delayed onset muscle soreness. The sham intervention was designed to mimic the attention and participation associated with the experimental intervention without providing the intended therapeutic effect.

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Pressure Pain Threshold
Tijdsspanne: Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.
Pressure pain threshold measured using a digital pressure algometer following experimentally induced delayed onset muscle soreness (DOMS).
Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.
Pain Intensity
Tijdsspanne: Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.
Pain intensity will be assessed using the Visual Analog Scale (VAS). The VAS consists of a 10-cm horizontal line ranging from 0 (no pain) to 10 (worst imaginable pain). Participants will indicate their perceived pain intensity by marking a point on the line. Higher scores indicate greater pain intensity.
Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Knee Joint Range of Motion
Tijdsspanne: Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.
Knee joint range of motion measured using a standard goniometer.
Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.
Quadriceps Muscle Strength
Tijdsspanne: Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.
Quadriceps muscle strength measured using a handheld dynamometer.
Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.
Thigh Circumference
Tijdsspanne: Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.
Thigh circumference measured using a tape measure to assess exercise-induced swelling.
Baseline, immediately after exercise, Day 1, Day 3, and Day 5 following DOMS induction.

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Istanbul Nisantasi University

Publicaties en nuttige links

De persoon die verantwoordelijk is voor het invoeren van informatie over het onderzoek stelt deze publicaties vrijwillig ter beschikking. Dit kan gaan over alles wat met het onderzoek te maken heeft.

Algemene publicaties

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Werkelijk)

1 april 2025

Primaire voltooiing (Werkelijk)

18 juli 2025

Studie voltooiing (Werkelijk)

18 juli 2025

Studieregistratiedata

Eerst ingediend

30 mei 2026

Eerst ingediend dat voldeed aan de QC-criteria

30 mei 2026

Eerst geplaatst (Werkelijk)

4 juni 2026

Updates van studierecords

Laatste update geplaatst (Werkelijk)

16 juni 2026

Laatste update ingediend die voldeed aan QC-criteria

13 juni 2026

Laatst geverifieerd

1 juni 2026

Meer informatie

Termen gerelateerd aan deze studie

Trefwoorden

Aanvullende relevante MeSH-voorwaarden

Andere studie-ID-nummers

  • OASIsometricDOMS

Plan Individuele Deelnemersgegevens (IPD)

Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?

JA

Beschrijving IPD-plan

De-identified individual participant data underlying the published results may be made available upon reasonable request to the corresponding author, subject to institutional approval and applicable ethical requirements.

IPD-tijdsbestek voor delen

De-identified individual participant data, study protocol, statistical analysis plan, and analytic code will be available beginning 6 months after publication of the primary study results and ending 5 years after publication.

IPD-toegangscriteria voor delen

De-identified individual participant data and supporting documents will be made available to qualified researchers upon reasonable request. Requests must include a methodologically sound research proposal and will be reviewed by the study investigators. Data will be provided after approval of the request and completion of an appropriate data-sharing agreement. Access will be limited to data necessary to achieve the approved research objectives.

IPD delen Ondersteunend informatietype

  • LEERPROTOCOOL
  • SAP
  • ANALYTIC_CODE

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

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