- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT00104585
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)
Genetic Epidemiology of Parkinson's Disease
Studieoversikt
Status
Forhold
Detaljert beskrivelse
Parkinson's disease (PD) is a common, neurodegenerative condition. Although mostly a late-onset disorder, 10 percent of people with PD are reported to develop symptoms before the age of 50. To date, six genes have been found to be associated with PD, however the majority have been found in rare PD 'families'. Some studies have also identified a number of environmental risk factors, such as pesticide use, that appear to increase the risk of PD.
In a previous study, Dr. Karen Marder and her research team found that close family members of people with both early- and late-onset PD have a three-fold increased risk of PD compared to close family members of people without PD.
The purpose of the Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) study is to identify the genetic factors that contribute to the development of early-onset Parkinson's disease, and to understand how these genetic factors interact with other genes and the environment to cause PD.
Participation in the study involves a blood draw (to look for genetic factors associated with PD), questionnaires collecting information on family and medical history, and a neurological examination. In addition participants may be contacted in the future and asked to participate in a more detailed interview. At that time, study investigators will also ask participants for permission to contact family members to invite them to participate in the study.
This research study requires participants to sign a consent form, which states that the research is voluntary and confidential. In addition, since this is a research study, genetic results are not released to participants or their family members now or in the future.
Scientists hope this multi-center study will increase the current knowledge of PD and that the identification of factors that cause PD will lead to better diagnosis and treatment.
Studietype
Registrering (Forventet)
Kontakter og plasseringer
Studiesteder
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California
-
Sunnyvale, California, Forente stater, 94089
- Aktiv, ikke rekrutterende
- The Parkinson's Institute
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Connecticut
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New Haven, Connecticut, Forente stater, 06510
- Aktiv, ikke rekrutterende
- The Institute for Neurodegenerative Disorders
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Illinois
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Chicago, Illinois, Forente stater, 60612
- Rekruttering
- Rush University Medical Center
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Ta kontakt med:
- Lucia M. Blasucci
- Telefonnummer: 312-563-2900
- E-post: Lucia_M_Blasucci@rush.edu
-
Glenview, Illinois, Forente stater, 60026
- Aktiv, ikke rekrutterende
- Glenbrook Hospital, Evanston
-
-
Maryland
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Baltimore, Maryland, Forente stater, 21287
- Aktiv, ikke rekrutterende
- Johns Hopkins Hospital
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-
Minnesota
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Golden Valley, Minnesota, Forente stater, 55427
- Aktiv, ikke rekrutterende
- Struthers Parkinson's Center
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New York
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New York, New York, Forente stater, 10032
- Rekruttering
- Columbia University
-
Ta kontakt med:
- Helen Mejia-Santana
- Telefonnummer: 877-305-2438
- E-post: research@corepdstudy.org
-
New York, New York, Forente stater, 10003
- Aktiv, ikke rekrutterende
- Beth Israel Medical Center
-
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Pennsylvania
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Philadelphia, Pennsylvania, Forente stater, 19104
- Aktiv, ikke rekrutterende
- University of Pennsylvania
-
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Rhode Island
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Warwick, Rhode Island, Forente stater, 02886
- Aktiv, ikke rekrutterende
- Neuro Health
-
-
Tennessee
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Memphis, Tennessee, Forente stater, 38136
- Aktiv, ikke rekrutterende
- University of Tennessee Health Science Center
-
-
Wisconsin
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Marshfield, Wisconsin, Forente stater, 54449
- Aktiv, ikke rekrutterende
- Marshfield Clinic
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-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Prøvetakingsmetode
Studiepopulasjon
Beskrivelse
Inclusion Criteria:
- Any person with Parkinson's disease in the United States whose symptoms began at age 50 or younger and was diagnosed by a neurologist.
Studieplan
Hvordan er studiet utformet?
Designdetaljer
Kohorter og intervensjoner
Gruppe / Kohort |
---|
1
People with young onset Parkinson's disease and their family members
|
Samarbeidspartnere og etterforskere
Sponsor
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Karen Marder, M.D., M.PH., Columbia University
Studierekorddatoer
Studer hoveddatoer
Studiestart
Primær fullføring (Forventet)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- AAAA5609
- R01NS036630 (U.S. NIH-stipend/kontrakt)
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .