Acute Ocular Effects of Cigarette Smoking
5. mai 2026 oppdatert av: Semih Çakmak, Istanbul University
Acute Effects of Cigarette Smoking on Corneal Tomographic and Biometric Parameters: A Prospective Controlled Study
This prospective study aims to evaluate the short-term effects of smoking on corneal tomographic and biometric measurements in healthy adults.
After baseline examinations and measurements are taken in both smoking and non-smoking participants, the same measurements will be repeated after 10 minutes of external exposure, and within-group and between-group changes will be compared.
The aim of the study is to determine whether acute smoking exposure leads to measurable immediate changes in corneal tomographic and biometric parameters.
Studieoversikt
Status
Rekruttering
Intervensjon / Behandling
Detaljert beskrivelse
This study is a single-center, prospective, and controlled study designed to evaluate the short-term effects of smoking on corneal tomographic and biometric measurements in healthy adults.
The study aimed to include 46 smokers and 46 non-smokers.
To avoid inter-eye correlation, only the right eye of each participant was evaluated.
All participants initially underwent a full ophthalmological examination and measurements were taken using a Pentacam device.
Afterward, all participants waited in standard outdoor conditions for 10 minutes.
During this time, participants in the smoking group smoked, while participants in the control group did not smoke.
The same measurements were repeated at the end of the period.
The study aimed to compare within-group and between-group differences in changes.
Studietype
Observasjonsmessig
Registrering (Antatt)
90
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiekontakt
- Navn: Semih Çakmak
- Telefonnummer: 902124142000
- E-post: semihcakmak@istanbul.edu.tr
Studiesteder
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Istanbul, Tyrkia (Türkiye), 34093
- Rekruttering
- Istanbul University, Istanbul Faculty of Medicine
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Ta kontakt med:
- Semih Çakmak
- Telefonnummer: 905375555141
- E-post: semihcakmak@istanbul.edu.tr
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-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
Tar imot friske frivillige
Ja
Prøvetakingsmetode
Ikke-sannsynlighetsprøve
Studiepopulasjon
Healthy adult smokers and non-smokers aged 18 to 60 years are planned to be included in this single-center study.
Beskrivelse
Inclusion Criteria:
- Healthy adults aged 18 to 60 years
- Current smokers in the smoking group
- Never-smokers in the control group
- Willing and able to undergo ophthalmic examination and Pentacam AXL measurements
Exclusion Criteria:
- History of ocular surgery or ocular trauma
- Presence of corneal disease, retinal disease, or ocular surface disorder
- Clinically significant dry eye disease
- Contact lens use within the last 2 weeks
- Use of medications that may affect the ocular surface or pupillary dynamics, including anticholinergics or sympathomimetics
- Systemic diseases such as diabetes mellitus or hypertension
- Former smoking history in the control group
- Use of electronic cigarettes or other tobacco products
- Inability to cooperate adequately for accurate measurement
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
Kohorter og intervensjoner
Gruppe / Kohort |
Intervensjon / Behandling |
|---|---|
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Smokers
Healthy adult participants with active cigarette smoking exposure who underwent baseline ophthalmic examination and Pentacam measurements, followed by repeat measurements after a standardized 10-minute outdoor period during which they smoked.
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Participants in the smoking group smoked cigarettes during a standardized 10-minute outdoor period between baseline and post-exposure assessments.
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Non-smokers
Healthy adult participants without cigarette smoking exposure who underwent baseline ophthalmic examination and Pentacam measurements, followed by repeat measurements after a standardized 10-minute outdoor period under the same environmental conditions without smoking.
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Participants in the control group remained in the same outdoor environment for 10 minutes without smoking between baseline and post-exposure assessments.
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in Pentacam-measured corneal pachymetry at the pupil center after acute cigarette smoking exposure
Tidsramme: Baseline and immediately after a standardized 10-minute outdoor exposure period
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Change (post-exposure minus baseline) in corneal pachymetry at the pupil center, measured in micrometers (µm) using Pentacam.
The magnitude of change will be compared between smokers and non-smokers.
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Baseline and immediately after a standardized 10-minute outdoor exposure period
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in Pentacam-measured corneal densitometry in the anterior 0-2 mm zone after acute cigarette smoking exposure
Tidsramme: Baseline and immediately after a standardized 10-minute outdoor exposure period
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Change (post-exposure minus baseline) in corneal densitometry in the anterior 0-2 mm zone, measured in grayscale units (GSU) using Pentacam.
The magnitude of change will be compared between smokers and non-smokers.
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Baseline and immediately after a standardized 10-minute outdoor exposure period
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Etterforskere
- Hovedetterforsker: Semih Çakmak, Istanbul University
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
15. februar 2026
Primær fullføring (Antatt)
1. mai 2026
Studiet fullført (Antatt)
1. mai 2026
Datoer for studieregistrering
Først innsendt
17. april 2026
Først innsendt som oppfylte QC-kriteriene
5. mai 2026
Først lagt ut (Faktiske)
12. mai 2026
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
12. mai 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
5. mai 2026
Sist bekreftet
1. mai 2026
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- IstanbulU-2026-3901546
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
NEI
IPD-planbeskrivelse
Individual participant data will not be shared because the study was not designed with a data-sharing plan and the dataset contains participant-level information.
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Nei
Studerer et amerikansk FDA-regulert enhetsprodukt
Nei
produkt produsert i og eksportert fra USA
Nei
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