Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training (HyperLa)
20. juli 2026 oppdatert av: Prof. Dr. Henning Wackerhage, Technical University of Munich
HyperLa: Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training: A Multi-centre Study by the HyperLa Study Group
The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training.
Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power.
Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body.
The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values.
This research may help explain why people respond differently to exercise and support the development of personalized training programs.
Studieoversikt
Status
Rekruttering
Intervensjon / Behandling
Detaljert beskrivelse
This multicentre, prospective, single-arm interventional cohort study aims to link metabolic phenotypes with physical adaptations.
- Primary Assessment: Glycolytic power is quantified via the vLapeak test, defined as the peak rate of blood lactate accumulation during a 10-second isokinetic or sprint-configured cycle ergometry test.
- Intervention: The 8-week resistance training program consists of two supervised sessions per week. Exercises include the leg press (or Smith-machine squat) and leg extensions, performed for 4 sets of 8-12 repetitions. Intensity progresses from an RPE of 6 to voluntary muscular failure by the third week.
- Measurements: Muscle hypertrophy is primarily assessed via ultrasound measurement of muscle thickness and cross-sectional area (CSA) of the thigh muscles before and after the intervention.
- Secondary Objectives: The study also evaluates changes in the plasma metabolome via venous blood samples and, at select sites, analyzes muscle biopsies for glycolytic enzyme activity and fiber type composition to further validate the vLapeak results.
Studietype
Intervensjonell
Registrering (Antatt)
120
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiekontakt
- Navn: Henning Wackerhage, Prof. Dr.
- Telefonnummer: +49 89 289 24480
- E-post: henning.wackerhage@tum.de
Studer Kontakt Backup
- Navn: Lara Becker
- E-post: lara.becker@tum.de
Studiesteder
-
-
Central Finland
-
Jyväskylä, Central Finland, Finland, 40014
- Rekruttering
- University of Jyväskylä, Faculty of Sport and Health Sciences
-
Ta kontakt med:
- Juha Ahtiainen, Prof. Dr.
- Telefonnummer: +358408053740
- E-post: juha.ahtiainen@jyu.fi
-
-
-
-
Limerick
-
Limerick, Limerick, Irland, V94 T9PX
- Rekruttering
- University of Limerick, Department of Physical Education and Sport Sciences (PESS)
-
Ta kontakt med:
- Brian Carson, Prof.
- Telefonnummer: +353 (0)61 20 2896
- E-post: Brian.Carson@ul.ie
-
-
-
-
Madrid
-
Madrid, Madrid, Spania, 28040
- Rekruttering
- Universidad Politécnica de Madrid, Facultad de Ciencias de la Actividad Física y del Deporte (INEF)
-
Ta kontakt med:
- Pedro José Benito, Prof. Dr.
- Telefonnummer: +34 91 336 40 12
- E-post: pedroj.benito@upm.es
-
-
-
-
Bavaria
-
München, Bavaria, Tyskland, 80809
- Rekruttering
- Technical University of Munich, TUM School of Medicine and Health
-
Ta kontakt med:
- Henning Wackerhage, Prof. Dr.
- Telefonnummer: +49 89 289 24480
- E-post: henning.wackerhage@tum.de
-
Ta kontakt med:
- Lara Becker
- E-post: lara.becker@tum.de
-
-
North Rhine-Westphalia
-
Cologne, North Rhine-Westphalia, Tyskland, 51147
- Rekruttering
- DLR Cologne, Department of Metabolism and Human Performance
-
Ta kontakt med:
- Dominik Pesta, Prof. Dr.
- Telefonnummer: +49 2203 601 2028
- E-post: dominik.pesta@dlr.de
-
Düsseldorf, North Rhine-Westphalia, Tyskland, 40233
- Rekruttering
- iST University of Applied Sciences
-
Ta kontakt med:
- Stephan Geisler, Prof.Dr.
- Telefonnummer: +49 211 86668 6104
- E-post: sgeisler@ist-hochschule.de
-
Ta kontakt med:
- Tim Havers
- E-post: thavers@ist-hochschule.de
-
-
Saxony
-
Chemnitz, Saxony, Tyskland, 09126
- Rekruttering
- TU Chemnitz, Sports Medicine and Exercise Therapy
-
Ta kontakt med:
- Nico Nitzsche, PD Dr. Dr.
- Telefonnummer: +49 371 531-37326
- E-post: nico.nitzsche@hsw.tu-chemnitz.de
-
Leipzig, Saxony, Tyskland, 04109
- Rekruttering
- Institute for Applied Training Science (IAT) Leipzig
-
Ta kontakt med:
- Katharina Dunst, Dr.
- Telefonnummer: +49 341 4945-184
- E-post: AnnaKatharina.Dunst@sport-iat.de
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
Tar imot friske frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Body Mass Index (BMI) between 20-29 kg/m2
- No structured resistance training performed in the last twelve months.
- Maximum of four sessions per week of recreational or low-to-moderate aerobic endurance activity.
- No history of competitive strength or physique sports.
Exclusion Criteria:
- Diagnosed cardiovascular, pulmonary, metabolic, neuromuscular, or orthopaedic disease that contraindicates exercise.
- Positive response to any question on the PAR-Q 2025 questionnaire.
- Current use of anabolic steroids, creatine, or other substances known to strongly influence muscle hypertrophy.
- Regular engagement in shift work.
- Women who are pregnant or breastfeeding.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: N/A
- Intervensjonsmodell: Enkeltgruppeoppdrag
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Resistance Training Group
Participants in this single-arm cohort will undergo an 8-week standardized, hypertrophy-focused lower-body resistance training program.
|
Standardized training consisting of twice-weekly supervised sessions for 8 weeks.
Each session includes 4 sets of 8-12 repetitions of leg press (or Smith-machine squat) and leg extensions.
Training intensity progresses from an RPE of 6 to voluntary muscular failure starting from week three.
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in mid-thigh Muscle Thickness
Tidsramme: Baseline and Week 8 (completion of training intervention)
|
Change in mid-thigh muscle thickness (combination of rectus femoris and vastus intermedius) as measured by ultrasound.
|
Baseline and Week 8 (completion of training intervention)
|
|
Change in lateral-thigh Muscle Thickness
Tidsramme: Baseline and Week 8 (completion of training intervention)
|
Change in lateral thigh muscle thickness (combination of vastus lateralis and vastus intermedius) as measured by ultrasound.
|
Baseline and Week 8 (completion of training intervention)
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in Peak Rate of Blood Lactate Accumulation (vLapeak)
Tidsramme: Baseline and Week 8 (completion of training intervention)
|
Peak rate of blood lactate accumulation before and after a 10-second all-out seated cycle ergometry test.
Blood lactate will be sampled every minute for 10 minutes post-test to capture the peak value.
|
Baseline and Week 8 (completion of training intervention)
|
|
Change in Vastus Lateralis Muscle Cross-Sectional Area (CSA)
Tidsramme: Baseline and Week 8 (completion of training intervention)
|
Change in cross-sectional area of the vastus lateralis at 50% of muscle length measured via ultrasound.
|
Baseline and Week 8 (completion of training intervention)
|
|
Maximal Strength (3RM) for Leg Press
Tidsramme: Baseline and Week 8 (completion of training intervention)
|
Change in 3-Repetition Maximum (3RM) for the leg press exercise to assess lower-body multi-joint maximal strength.
|
Baseline and Week 8 (completion of training intervention)
|
|
Maximal Strength (3RM) for Leg Exentsion
Tidsramme: Baseline and Week 8 (completion of training intervention)
|
Change in 3-Repetition Maximum (3RM) for the leg extension exercise to assess single-joint quadriceps strength.
|
Baseline and Week 8 (completion of training intervention)
|
|
Change in Relative Abundance of Selected Plasma Metabolites
Tidsramme: Baseline and Week 8 (completion of training intervention)
|
Change in the relative concentration of targeted plasma metabolites from baseline to Week 8, as analyzed via mass spectrometry.
|
Baseline and Week 8 (completion of training intervention)
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Publikasjoner og nyttige lenker
Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.
Generelle publikasjoner
- Ahtiainen JP, Walker S, Peltonen H, Holviala J, Sillanpaa E, Karavirta L, Sallinen J, Mikkola J, Valkeinen H, Mero A, Hulmi JJ, Hakkinen K. Heterogeneity in resistance training-induced muscle strength and mass responses in men and women of different ages. Age (Dordr). 2016 Feb;38(1):10. doi: 10.1007/s11357-015-9870-1. Epub 2016 Jan 15.
- Warburg O, Wind F, Negelein E. THE METABOLISM OF TUMORS IN THE BODY. J Gen Physiol. 1927 Mar 7;8(6):519-30. doi: 10.1085/jgp.8.6.519. No abstract available.
- Wackerhage H, Kabasakalis A, Seiler S, Heck H. Is the vLamax for Glycolysis What the V O 2 max is for Oxidative Phosphorylation? Sports Med. 2025 Aug;55(8):1853-1866. doi: 10.1007/s40279-025-02259-6. Epub 2025 Jul 17.
- Wackerhage H, Vechetti IJ, Baumert P, Gehlert S, Becker L, Jaspers RT, de Angelis MH. Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell? Sports Med. 2022 Nov;52(11):2569-2578. doi: 10.1007/s40279-022-01676-1. Epub 2022 Apr 23.
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
4. mai 2026
Primær fullføring (Antatt)
1. desember 2026
Studiet fullført (Antatt)
1. desember 2026
Datoer for studieregistrering
Først innsendt
25. juni 2026
Først innsendt som oppfylte QC-kriteriene
20. juli 2026
Først lagt ut (Faktiske)
23. juli 2026
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
23. juli 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
20. juli 2026
Sist bekreftet
1. juni 2026
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Andre studie-ID-numre
- HyperLa
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
UBESLUTTE
IPD-planbeskrivelse
A formal plan for sharing individual participant data (IPD) with external researchers has not yet been finalized.
The study involves a multicentric international consortium with strict data protection requirements under GDPR.
Data is currently managed centrally via REDCap at the Technical University of Munich.
Requests for data sharing will be considered on a case-by-case basis by the HyperLa Study Group after the primary publication of results, and would require a formal proposal and a signed Data Access or Material Transfer Agreement (MTA)
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Nei
Studerer et amerikansk FDA-regulert enhetsprodukt
Nei
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .