Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma
Anthony R Cillo, Amrita Krishnan, Ronald T Mitsuyasu, Deborah K McMahon, Shirley Li, John J Rossi, John A Zaia, John W Mellors, Anthony R Cillo, Amrita Krishnan, Ronald T Mitsuyasu, Deborah K McMahon, Shirley Li, John J Rossi, John A Zaia, John W Mellors
Abstract
A cure of HIV-1 has been achieved in one individual through allogeneic stem cell transplantation with a CCR5[INCREMENT]32 homozygous donor. Whether myeloablation and autologous stem cell transplantation for lymphoma in patients on suppressive antiretroviral therapy can eliminate HIV-1 reservoirs is unknown. Low-level plasma viremia and total HIV-1 DNA and 2-LTR circles in blood mononuclear cells were quantified after autologous transplantation in 10 patients on suppressive antiretroviral therapy using quantitative polymerase chain reaction assays capable of single-copy nucleic acid detection. Plasma viremia was detectable in 9 patients, whereas HIV-1 DNA was detectable in all 10 patients, indicating that HIV-1 had not been eliminated.
Conflict of interest statement
Conflicts of Interest: J.W.M. is a consultant for Gilead Sciences and RFS Pharma and owns shares of RFS Pharma. A.R.C., A.K., R.T.M., D.K.M., S.L., J.J.R., and J.A.Z. have no conflicts of interest relevant to this article.
Source: PubMed