Why We Need Specialised Centres for Women's Hearts: Changing the Face of Cardiovascular Care for Women

Martha Gulati, Cara Hendry, Biljana Parapid, Sharon L Mulvagh, Martha Gulati, Cara Hendry, Biljana Parapid, Sharon L Mulvagh

Abstract

Although cardiovascular disease (CVD) is the leading cause of mortality in women globally, cardiovascular care for women remains suboptimal, with poorer outcomes than for men. During the past two decades, there has been an incremental increase in research and publications on CVD in women, addressing sex-specific risk factors, symptoms, pathophysiology, treatment, prevention and identification of inequities in care. Nonetheless, once women have manifested CVD, they continue to have increasingly worse outcomes than men. An approach to addressing these global disparities has been the worldwide establishment of specialised centres providing cardiovascular care for women. These women's heart centres (WHCs) allow a comprehensive approach to the cardiovascular care of women across the lifespan. The purpose of this article is to define the need for and role of these specialised centres by outlining sex-specific gaps in CVD care, and to provide guidance on components within WHCs that may be considered when establishing such programmes.

Keywords: Sex differences; cardiovascular disease; inequities; prevention; women; women’s heart centres.

Conflict of interest statement

Disclosure: MG is a Guest Editor of the Women and Heart Disease special collection for European Cardiology Review. All other authors have no conflicts of interest to declare.

Copyright © 2021, Radcliffe Cardiology.

Figures

Figure 1:. Traditional and Sex-specific Risk Factors…
Figure 1:. Traditional and Sex-specific Risk Factors in Women
Figure 2:. Components of a Women’s Heart…
Figure 2:. Components of a Women’s Heart Centre

References

    1. GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1204–22. doi: 10.1016/S0140-6736(20)30925-9.
    1. Gulati M. Yentl's bikini: sex differences in STEMI. J Am Heart Assoc. 2019;8:e012873. doi: 10.1161/JAHA.119.012873.
    1. Gulati M. Improving the cardiovascular health of women in the nation: moving beyond the bikini boundaries. Circulation. 2017;135:495–8. doi: 10.1161/CIRCULATIONAHA.116.025303.
    1. Low TT, Chan SP, Wai SH et al. The women's heart health programme: a pilot trial of sex-specific cardiovascular management. BMC Womens Health. 2018;18:56. doi: 10.1186/s12905-018-0548-6.
    1. Garcia M, Miller VM, Gulati M et al. Focused cardiovascular care for women: the need and role in clinical practice. Mayo Clin Proc. 2016;91:226–40. doi: 10.1016/j.mayocp.2015.11.001.
    1. Brown N. How the American Heart Association helped change women’s heart health. Circ Cardiovasc Qual Outcomes. 2015;8((2 Suppl 1)):S60–2. doi: 10.1161/CIRCOUTCOMES.115.001734.
    1. Vogel B, Acevedo M, Appelman Y et al. The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030. Lancet. 2021;397:2385–438. doi: 10.1016/S0140-6736(21)00684-X.
    1. Virani SS, Alonso A, Aparicio HJ et al. Heart disease and stroke statistics – 2021 update: a report from the American Heart Association. Circulation. 2021;143:e254–743. doi: 10.1161/CIR.0000000000000950.
    1. Khan SU, Yedlapati SH, Lone AN A comparative analysis of premature heart disease- and cancer-related mortality in women in the USA, 1999–2018. Eur Heart J Qual Care Clin Outcomes. 2021. epub ahead of press.
    1. Cushman M, Shay CM, Howard VJ et al. Ten-year differences in women’s awareness related to coronary heart disease: results of the 2019 American Heart Association national survey: a special report from the American Heart Association. Circulation. 2021;143:e239–48. doi: 10.1161/CIR.0000000000000907.
    1. Bairey Merz CN, Andersen H, Sprague E et al. Knowledge, attitudes, and beliefs regarding cardiovascular disease in women: the Women's Heart Alliance. J Am Coll Cardiol. 2017;70:123–32. doi: 10.1016/j.jacc.2017.05.024.
    1. Lundberg GP, Mehta LS, Sanghani RM et al. Heart centers for women: historical perspective on formation and future strategies to reduce cardiovascular disease. Circulation. 2018;138:1155–65. doi: 10.1161/CIRCULATIONAHA.118.035351.
    1. Jneid H, Fonarow GC, Cannon CP et al. Sex differences in medical care and early death after acute myocardial infarction. Circulation. 2008;118:2803–10. doi: 10.1161/CIRCULATIONAHA.108.789800.
    1. Reuter H, Markhof A, Scholz S et al. Long-term medication adherence in patients with ST-elevation myocardial infarction and primary percutaneous coronary intervention. Eur J Prev Cardiol. 2015;22:890–8. doi: 10.1177/2047487314540385.
    1. Hao Y, Liu J, Liu J et al. Sex differences in in-hospital management and outcomes of patients with acute coronary syndrome. Circulation. 2019;139:1776–85. doi: 10.1161/CIRCULATIONAHA.118.037655.
    1. Samayoa L, Grace SL, Gravely S et al. Sex differences in cardiac rehabilitation enrollment: a meta-analysis. Can J Cardiol. 2014;30:793–800. doi: 10.1016/j.cjca.2013.11.007.
    1. Ya'qoub L, Lemor A, Dabbagh M et al. Racial, ethnic, and sex disparities in patients with STEMI and cardiogenic shock. JACC Cardiovasc Interv. 2021;14:653–60. doi: 10.1016/j.jcin.2021.01.003.
    1. Thompson LE, Maddox TM, Lei L et al. Sex differences in the use of oral anticoagulants for atrial fibrillation: a report from the National Cardiovascular Data Registry (NCDR®) PINNACLE Registry. J Am Heart Assoc. 2017;6:e005801. doi: 10.1161/JAHA.117.005801.
    1. Schnabel RB, Pecen L, Ojeda FM et al. Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation. Heart. 2017;103:1024–30. doi: 10.1136/heartjnl-2016-310406.
    1. Curtis LH, Al-Khatib SM, Shea AM et al. Sex differences in the use of implantable cardioverter-defibrillators for primary and secondary prevention of sudden cardiac death. JAMA. 2007;298:1517–24. doi: 10.1001/jama.298.13.1517.
    1. Patel NJ, Edla S, Deshmukh A et al. Gender, racial, and health insurance differences in the trend of implantable cardioverter-defibrillator (ICD) utilization: a United States experience over the last decade. Clin Cardiol. 2016;39:63–71. doi: 10.1002/clc.22496.
    1. Xia S, Du X, Guo L et al. Sex differences in primary and secondary prevention of cardiovascular disease in China. Circulation. 2020;141:530–9. doi: 10.1161/CIRCULATIONAHA.119.043731.
    1. Stehli J, Martin C, Brennan A et al. Sex differences persist in time to presentation, revascularization, and mortality in myocardial infarction treated with percutaneous coronary intervention. J Am Heart Assoc. 2019;8:e012161. doi: 10.1161/JAHA.119.012161.
    1. Cenko E, Yoon J, Kedev S et al. Sex differences in outcomes after STEMI: effect modification by treatment strategy and age. JAMA Intern Med. 2018;178:632–9. doi: 10.1001/jamainternmed.2018.0514.
    1. Healy B. The Yentl syndrome. N Engl J Med. 1991;325:274–6. doi: 10.1056/NEJM199107253250408.
    1. Jin X, Chandramouli C, Allocco B et al. Women's participation in cardiovascular clinical trials from 2010 to 2017. Circulation. 2020;141:540–8. doi: 10.1161/CIRCULATIONAHA.119.043594.
    1. Scott PE, Unger EF, Jenkins MR et al. Participation of women in clinical trials supporting FDA approval of cardiovascular drugs. J Am Coll Cardiol. 2018;71:1960–9. doi: 10.1016/j.jacc.2018.02.070.
    1. Clayton JA, Collins FS. Policy. NIH to balance sex in cell and animal studies. Nature. 2014;509:282–3. doi: 10.1038/509282a.
    1. van Spall HGC, Lala A, Deering TF et al. Ending gender inequality in cardiovascular clinical trial leadership: JACC review topic of the week. J Am Coll Cardiol. 2021;77:2960–72. doi: 10.1016/j.jacc.2021.04.038.
    1. Heidari S, Babor TF, De Castro P et al. Sex and gender equity in research: rationale for the SAGER guidelines and recommended use. Res Integr Peer Rev. 2016;1:2. doi: 10.1186/s41073-016-0007-6.
    1. Connelly PJ, Azizi Z, Alipour P et al. The importance of gender to understand sex differences in cardiovascular disease. Can J Cardiol. 2021;37:699–710. doi: 10.1016/j.cjca.2021.02.005.
    1. Maas AH, van der Schouw YT, Regitz-Zagrosek V et al. Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women: proceedings of the workshop held in Brussels on gender differences in cardiovascular disease, 29 September 2010. Eur Heart J. 2011;32:1362–8. doi: 10.1093/eurheartj/ehr048.
    1. Elder P, Sharma G, Gulati M, Michos ED. Identification of female-specific risk enhancers throughout the lifespan of women to improve cardiovascular disease prevention. Am J Prev Cardiol. 2020;2:100028. doi: 10.1016/j.ajpc.2020.100028.
    1. Garcia M, Mulvagh SL, Merz CN et al. Cardiovascular disease in women: clinical perspectives. Circ Res. 2016;118:1273–93. doi: 10.1161/CIRCRESAHA.116.307547.
    1. Tamis-Holland JE, Jneid H, Reynolds HR et al. Contemporary diagnosis and management of patients with myocardial infarction in the absence of obstructive coronary artery disease: a scientific statement from the American Heart Association. Circulation. 2019;139:e891–908. doi: 10.1161/CIR.0000000000000670.
    1. Kunadian V, Chieffo A, Camici PG et al. An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation endorsed by Coronary Vasomotor Disorders International Study Group. Eur Heart J. 2020;41:3504–20. doi: 10.1093/eurheartj/ehaa503.
    1. Beale AL, Meyer P, Marwick TH et al. Sex differences in cardiovascular pathophysiology: why women are overrepresented in heart failure with preserved ejection fraction. Circulation. 2018;138:198–205. doi: 10.1161/CIRCULATIONAHA.118.034271.
    1. Aggarwal NR, Mulvagh SL. Chapter 29 – women's heart programs. In: Aggarwal NR, Wood MJ, eds. Sex Differences in Cardiac Disease. Elsevier. 2021. pp. 671–86.
    1. Gulati M, Mulvagh SL. The connection between the breast and heart in a woman: breast cancer and cardiovascular disease. Clin Cardiol. 2018;41:253–7. doi: 10.1002/clc.22886.
    1. Prasad M, Hermann J, Gabriel SE et al. Cardiorheumatology: cardiac involvement in systemic rheumatic disease. Nat Rev Cardiol. 2015;12:168–76. doi: 10.1038/nrcardio.2014.206.
    1. Scanlon EM, Mankad R, Crowson CS et al. Cardiovascular risk assessment in patients with rheumatoid arthritis: a correlative study of noninvasive arterial health testing. Clin Rheumatol. 2017;36:763–71. doi: 10.1007/s10067-016-3515-3.
    1. Connelly PJ, Marie Freel E et al. Gender-affirming hormone therapy, vascular health and cardiovascular disease in transgender adults. Hypertension. 2019;74:1266–74. doi: 10.1161/HYPERTENSIONAHA.119.13080.

Source: PubMed

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