Safety and efficacy of brentuximab vedotin for Hodgkin lymphoma recurring after allogeneic stem cell transplantation
Ajay K Gopal, Radhakrishnan Ramchandren, Owen A O'Connor, Robert B Berryman, Ranjana H Advani, Robert Chen, Scott E Smith, Maureen Cooper, Achim Rothe, Jeffrey V Matous, Laurie E Grove, Jasmine Zain, Ajay K Gopal, Radhakrishnan Ramchandren, Owen A O'Connor, Robert B Berryman, Ranjana H Advani, Robert Chen, Scott E Smith, Maureen Cooper, Achim Rothe, Jeffrey V Matous, Laurie E Grove, Jasmine Zain
Abstract
Hodgkin lymphoma (HL) relapsing after allogeneic stem cell transplantation (alloSCT) presents a major clinical challenge. In the present investigation, we evaluated brentuximab vedotin, a CD30-directed Ab-drug conjugate, in 25 HL patients (median age, 32 years; range, 20-56) with recurrent disease after alloSCT (11 unrelated donors). Patients were > 100 days after alloSCT, had no active GVHD, and received a median of 9 (range, 5-19) prior regimens. Nineteen (76%) had refractory disease immediately before enrollment. Patients received 1.2 or 1.8 mg/kg of brentuximab vedotin IV every 3 weeks (median, 8 cycles; range, 1-16). Overall and complete response rates were 50% and 38%, respectively, among 24 evaluable patients. Median time to response was 8.1 weeks, median progression-free survival was 7.8 months, and the median overall survival was not reached. Cough, fatigue, and pyrexia (52% each), nausea and peripheral sensory neuropathy (48% each), and dyspnea (40%) were the most frequent adverse events. The most common adverse events ≥ grade 3 were neutropenia (24%), anemia (20%), thrombocytopenia (16%), and hyperglycemia (12%). Cytomegalovirus was detected in 5 patients (potentially clinically significant in 1). These results support the potential utility of brentuximab vedotin for selected patients with HL relapsing after alloSCT.
Trial registration: ClinicalTrials.gov NCT00947856 NCT01026233 NCT01026415.
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Source: PubMed