Observational study on fluid therapy management in surgical adult patients

Abstract

Background: Perioperative fluid therapy management is changing due to the incorporation of different fluids, surgical techniques, and minimally invasive monitoring systems. The objective of this study was to explore fluid therapy management during the perioperative period in our country.

Methods: We designed the Fluid Day study as a cross-sectional, multicentre, observational study. The study was performed in 131 Spanish hospitals in February 2019. We included adult patients undergoing general anaesthesia for either elective or non-elective surgery. Demographic variables were recorded, as well as the type and total volume of fluid administered during the perioperative period and the monitorization used. To perform the analysis, patients were categorized by risk group.

Results: We recruited 7291 patients, 6314 of which were included in the analysis; 1541 (24.4%) patients underwent high-risk surgery, 1497 (23. 7%) were high risk patients, and 554 (8.7%) were high-risk patients and underwent high-risk surgery; 98% patients received crystalloids (80% balanced solutions); intraoperative colloids were used in 466 patients (7.51%). The hourly intraoperative volume in mL/kg/h and the median [Q1; Q3] administered volume (mL/kg) were, respectively, 6.67 [3.83; 8.17] ml/Kg/h and 13.9 [9.52;5.20] ml/Kg in low-risk patients undergoing low- or intermediate-risk surgery, 6 [4.04; 9.08] ml/Kg/h and 15.7 [10.4;24.5] ml/Kg in high- risk patients undergoing low or intermediate-risk surgery, 6.41 [4.36; 9.33] ml/Kg/h and 20.2 [13.3;32.4] ml/Kg in low-risk patients undergoing high-risk surgery, and 5.46 [3.83; 8.17] ml/Kg/h and 22.7[14.1;40.9] ml/Kg in high-risk patients undergoing high- risk surgery . We used advanced fluid monitoring strategies in 5% of patients in the intraoperative period and in 10% in the postoperative period.

Conclusions: The most widely used fluid was balanced crystalloids. Colloids were used in a small number of patients. Hourly surgery volume tended to be more restrictive in high-risk patients but confirms a high degree of variation in the perioperatively administered volume. Scarce monitorization was observed in fluid therapy management.

Trial registration: Clinical Trials: NCT03630744.

Keywords: Balanced crystalloids; Fluid therapy; Fluid therapy management; Hemodynamic monitoring; Practice guidelines; Surgical procedures.

Conflict of interest statement

MJC: Honoraria for meetings and honoraria from Baxtex - Spain for conferences and courses.

JR-M: Honoraria for conference and courses from Fresenius Kabi, Edwards Lifesciences and Dextera Medical.

CC: Honoraria for Baxter- Spain Conferences.

JLJ: Honoraria for Fresenius Kabi conferences.

PG: Honoraria for Baxter- Spain Conferences.

MB, RF, JVLL, JP: no competing interests.

© 2021. The Author(s).

Figures

Fig. 1

Flowchart

Fig. 2

Fluid type (Prevalence and IC[95%]). HES: Hydroxyethyl starch

Fig. 3

Density plot of ml/Kg of Crystalloids. * 15 patients with more than 100 ml/Kg in total were removed. In the densities graph we observe that, during the intraoperative period in most of the surgeries, the total ml/kg are concentrated between 0 and 20. In contrast, in the postoperative period we see that, the greater the patient and surgery risk, the more variability in the total ml/kg administered. This same variability is observed in the total administered volume in both the intra and postoperative periods