Intake of dietary phylloquinone and menaquinones and risk of stroke

Linda E T Vissers, Geertje W Dalmeijer, Jolanda M A Boer, W M Monique Verschuren, Yvonne T van der Schouw, Joline W J Beulens, Linda E T Vissers, Geertje W Dalmeijer, Jolanda M A Boer, W M Monique Verschuren, Yvonne T van der Schouw, Joline W J Beulens

Abstract

Background: Dietary vitamin K intake is thought to decrease the risk of cardiovascular disease (CVD) by reducing vascular calcification, although vitamin K is also involved in coagulation. Studies investigating the association between phylloquinone intake and risk of stroke are scarce, and the relation with menaquinones has not been investigated to date.

Methods and results: We investigated the association between intake of phylloquinone and menaquinones and stroke in a prospective cohort of 35,476 healthy subjects. Information on occurrence of stroke was obtained by linkage to national registries, and stroke was further specified into ischemic and hemorrhagic stroke. Vitamin K intake was estimated using a validated food-frequency questionnaire. Multivariate Cox proportional hazards models adjusted for cardiovascular risk factors, lifestyle, and other dietary factors were used to estimate the associations. During a follow-up of 12.1 ± 2.1 years, 580 incident cases of stroke were identified, 163 of which were hemorrhagic and 324 were ischemic. Phylloquinone intake was not associated with risk of stroke with a hazard ratio (HR) of 1.09 (95% CI: 0.85 to 1.40, P(trend) 0.41) for the highest versus lowest quartile. For intake of menaquinones similar results were found, with an HR(Q4 versus Q1) of 0.99 (95% CI: 0.75 to 1.29, P(trend) 0.82). When specifying hemorrhagic and ischemic stroke or menaquinone subtypes, no significant associations were detected.

Conclusion: In our study, neither dietary phylloquinone nor dietary menaquinones intake were associated with stroke risk.

Keywords: diet; menaquinone; phylloquinone; stroke; vitamin K.

References

    1. Bolton‐Smith C, Price RJ, Fenton ST, Harrington DJ, Shearer MJ. Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. Br J Nutr. 2000; 83:389-399
    1. Schurgers LJ, Vermeer C. Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. Haemostasis. 2000; 30:298-307
    1. Cranenburg EC, Schurgers LJ, Vermeer C. Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost. 2007; 98:120-125
    1. Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft‐tissue calcification. Adv Nutr. 2012; 3:166-173
    1. Schurgers LJ, Vermeer C. Differential lipoprotein transport pathways of K‐vitamins in healthy subjects. Biochim Biophys Acta. 2002; 1570:27-32
    1. Furie B, Bouchard BA, Furie BC. Vitamin K‐dependent biosynthesis of gamma‐carboxyglutamic acid. Blood. 1999; 93:1798-1808
    1. Spronk HM, Soute BA, Schurgers LJ, Cleutjens JP, Thijssen HH, De Mey JG, Vermeer C. Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall. Biochem Biophys Res Commun. 2001; 289:485-490
    1. Price PA, Faus SA, Williamson MK. Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler Thromb Vasc Biol. 1998; 18:1400-1407
    1. Schurgers LJ, Aebert H, Vermeer C, Bultmann B, Janzen J. Oral anticoagulant treatment: friend or foe in cardiovascular disease? Blood. 2004; 104:3231-3232
    1. Chatrou ML, Winckers K, Hackeng TM, Reutelingsperger CP, Schurgers LJ. Vascular calcification: the price to pay for anticoagulation therapy with vitamin K‐antagonists. Blood Rev. 2012; 26:155-166
    1. Schurgers LJ, Joosen IA, Laufer EM, Chatrou ML, Herfs M, Winkens MH, Westenfeld R, Veulemans V, Krueger T, Shanahan CM, Jahnen‐Dechent W, Biessen E, Narula J, Vermeer C, Hofstra L, Reutelingsperger CP. Vitamin K‐antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype. PLoS ONE. 2012; 7:e43229.
    1. Rennenberg RJ, van Varik BJ, Schurgers LJ, Hamulyak K, Ten CH, Leiner T, Vermeer C, de Leeuw PW, Kroon AA. Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans. Blood. 2010; 115:5121-5123
    1. Beulens JW, Bots ML, Atsma F, Bartelink ML, Prokop M, Geleijnse JM, Witteman JC, Grobbee DE, van der Schouw YT. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009; 203:489-493
    1. Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004; 134:3100-3105
    1. Gast GC, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis. 2009; 19:504-510
    1. Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson‐Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL. Vitamin K supplementation and progression of coronary artery calcium in older men and women. Am J Clin Nutr. 2009; 89:1799-1807
    1. Erkkila AT, Booth SL, Hu FB, Jacques PF, Manson JE, Rexrode KM, Stampfer MJ, Lichtenstein AH. Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women. Eur J Clin Nutr. 2005; 59:196-204
    1. Erkkila AT, Booth SL, Hu FB, Jacques PF, Lichtenstein AH. Phylloquinone intake and risk of cardiovascular diseases in men. Nutr Metab Cardiovasc Dis. 2007; 17:58-62
    1. Usui Y, Tanimura H, Nishimura N, Kobayashi N, Okanoue T, Ozawa K. Vitamin K concentrations in the plasma and liver of surgical patients. Am J Clin Nutr. 1990; 51:846-852
    1. Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C. Role of vitamin K and vitamin K‐dependent proteins in vascular calcification. Z Kardiol. 2001; 90suppl 3:57-63
    1. Will BH, Suttie JW. Comparative metabolism of phylloquinone and menaquinone‐9 in rat liver. J Nutr. 1992; 122:953-958
    1. Kindberg CG, Suttie JW. Effect of various intakes of phylloquinone on signs of vitamin K deficiency and serum and liver phylloquinone concentrations in the rat. J Nutr. 1989; 119:175-180
    1. Booth SL, Martini L, Peterson JW, Saltzman E, Dallal GE, Wood RJ. Dietary phylloquinone depletion and repletion in older women. J Nutr. 2003; 133:2565-2569
    1. McCann JC, Ames BN. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr. 2009; 90:889-907
    1. Beulens JW, Monninkhof EM, Verschuren WM, van der Schouw YT, Smit J, Ocke MC, Jansen EH, van Dieren S, Grobbee DE, Peeters PH, Bueno‐de‐Mesquita HB. Cohort profile: the EPIC‐NL study. Int J Epidemiol. 2010; 39:1170-1178
    1. Haftenberger M, Schuit AJ, Tormo MJ, Boeing H, Wareham N, Bueno‐de‐Mesquita HB, Kumle M, Hjartaker A, Chirlaque MD, Ardanaz E, Andren C, Lindahl B, Peeters PH, Allen NE, Overvad K, Tjonneland A, Clavel‐Chapelon F, Linseisen J, Bergmann MM, Trichopoulou A, Lagiou P, Salvini S, Panico S, Riboli E, Ferrari P, Slimani N. Physical activity of subjects aged 50‐64 years involved in the European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr. 2002; 5:1163-1176
    1. Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE. Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr. 2003; 6:407-413
    1. Ocke MC, Bueno‐de‐Mesquita HB, Pols MA, Smit HA, van Staveren WA, Kromhout D. The Dutch EPIC food frequency questionnaire. II. Relative validity and reproducibility for nutrients. Int J Epidemiol. 1997; 26suppl 1:S49-S58
    1. Heijden LJMvd, Hulshof KFAM, Langius JAE, Oosten HMv, Pruissen‐Boskaljon JC. NEVO Tabel: Nederlands Voedingsstoffenbestand, 1996. 2012Den Haag: Voorlichtingsbureau voor de voeding
    1. Booth SL, Sadowski JA, Weihrauch JL, Ferland G. Vitamin K‐1 (phylloquinone) content of common foods: a provisional table. J Food Comp Anal. 1993; 6:109-120
    1. Shearer MJ, Bach A, Kohlmeier M. Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. J Nutr. 1996; 126:1181S-1186S
    1. Suttie JW. Vitamin K and human nutrition. J Am Diet Assoc. 1992; 92:585-590
    1. Booth SL, Madabushi HT, Davidson KW, Sadowski JA. Tea and coffee brews are not dietary sources of vitamin K‐1 (phylloquinone). J Am Diet Assoc. 1995; 95:82-83
    1. Ferland G, MacDonald DL, Sadowski JA. Development of a diet low in vitamin K‐1 (phylloquinone). J Am Diet Assoc. 1992; 92:593-597
    1. Herings RM, Bakker A, Stricker BH, Nap G. Pharmaco‐morbidity linkage: a feasibility study comparing morbidity in two pharmacy based exposure cohorts. J Epidemiol Community Health. 1992; 46:136-140
    1. Nagel G, Zoller D, Ruf T, Rohrmann S, Linseisen J. Long‐term reproducibility of a food‐frequency questionnaire and dietary changes in the European Prospective Investigation into Cancer and Nutrition (EPIC)—Heidelberg cohort. Br J Nutr. 2007; 98:194-200
    1. Tolonen H, Salomaa V, Torppa J, Sivenius J, Immonen‐Raiha P, Lehtonen A. The validation of the Finnish Hospital Discharge Register and Causes of Death Register data on stroke diagnoses. Eur J Cardiovasc Prev Rehabil. 2007; 14:380-385
    1. Krarup LH, Boysen G, Janjua H, Prescott E, Truelsen T. Validity of stroke diagnoses in a National Register of Patients. Neuroepidemiology. 2007; 28:150-154
    1. Benesch C, Witter DM, Jr, Wilder AL, Duncan PW, Samsa GP, Matchar DB. Inaccuracy of the International Classification of Diseases (ICD‐9‐CM) in identifying the diagnosis of ischemic cerebrovascular disease. Neurology. 1997; 49:660-664
    1. Larsson SC, Mannisto S, Virtanen MJ, Kontto J, Albanes D, Virtamo J. Dairy foods and risk of stroke. Epidemiology. 2009; 20:355-360
    1. Goldbohm RA, Chorus AM, Galindo GF, Schouten LJ, van den Brandt PA. Dairy consumption and 10‐y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr. 2011; 93:615-627
    1. Dalmeijer GW, Struijk EA, van der Schouw YT, Soedamah‐Muthu SS, Verschuren WM, Boer JM, Geleijnse JM, Beulens JW. Dairy intake and coronary heart disease or stroke—a population‐based cohort study. Int J Cardiol. 2013; 167:925-929
    1. Erkkila AT, Booth SL. Vitamin K intake and atherosclerosis. Curr Opin Lipidol. 2008; 19:39-42
    1. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990; 15:827-832
    1. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008; 358:1336-1345
    1. Kwee RM. Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms. J Vasc Surg. 2010; 51:1015-1025
    1. Ferland G. Vitamin K, an emerging nutrient in brain function. BioFactors. 2012; 38:151-157
    1. Liu D, Guo H, Griffin JH, Fernandez JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003; 107:1791-1796

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