Objective measures of physical capability and subsequent health: a systematic review

Rachel Cooper, Diana Kuh, Cyrus Cooper, Catharine R Gale, Debbie A Lawlor, Fiona Matthews, Rebecca Hardy, FALCon and HALCyon Study Teams, Avan Aihie Sayer, Eleni Bakra, Michaela Benzeval, Graciela Muniz Terrera, Andrew Wills, Yoav Ben-Shlomo, Leone Craig, Ian Day, Richard Martin, Kate Tilling, Tamuno Alfred, Mike Gardner, John Gallacher, Ian Deary, John Starr, Paul Shiels, Thomas von Zglinicki, Humphrey Southall, Paula Aucott, Jane Elliott, Chris Power, Geraldine McNeill, Avan Aihie Sayer, Alison Lennox, Marcus Richards, Gita Mishra, Zeinab Mulla, James Goodwin, Rachel Cooper, Diana Kuh, Cyrus Cooper, Catharine R Gale, Debbie A Lawlor, Fiona Matthews, Rebecca Hardy, FALCon and HALCyon Study Teams, Avan Aihie Sayer, Eleni Bakra, Michaela Benzeval, Graciela Muniz Terrera, Andrew Wills, Yoav Ben-Shlomo, Leone Craig, Ian Day, Richard Martin, Kate Tilling, Tamuno Alfred, Mike Gardner, John Gallacher, Ian Deary, John Starr, Paul Shiels, Thomas von Zglinicki, Humphrey Southall, Paula Aucott, Jane Elliott, Chris Power, Geraldine McNeill, Avan Aihie Sayer, Alison Lennox, Marcus Richards, Gita Mishra, Zeinab Mulla, James Goodwin

Abstract

Background: measures of physical capability may be predictive of subsequent health, but existing published studies have not been systematically reviewed. We hypothesised that weaker grip strength, slower walking speed and chair rising and shorter standing balance time, in community-dwelling populations, would be associated with higher subsequent risk of fracture, cognitive outcomes, cardiovascular disease, hospitalisation and institutionalisation.

Methods: studies were identified through systematic searches of the electronic databases MEDLINE and EMBASE (to May 2009). Reference lists of eligible papers were also manually searched.

Results: twenty-four papers had examined the associations between at least one physical capability measure and one of the outcomes. As the physical capability measures and outcomes had been assessed and categorised in different ways in different studies, and there were differences in the potential confounding factors taken into account, this made it impossible to pool results. There were more studies examining fractures than other outcomes, and grip strength and walking speed were the most commonly examined capability measures. Most studies found that weaker grip strength and slower walking speed were associated with increased risk of future fractures and cognitive decline, but residual confounding may explain results in some studies. Associations between physical capability levels and the other specified outcomes have not been tested widely.

Conclusions: there is some evidence to suggest that objective measures of physical capability may be predictors of subsequent health in older community-dwelling populations. Most hypothesised associations have not been studied sufficiently to draw definitive conclusions suggesting the need for further research.

Figures

Figure 1.
Figure 1.
Flow diagram for identification of published studies.

References

    1. Cooper R, Kuh D, Hardy R, et al. Objectively measured physical capability levels and mortality: a systematic review and meta-analysis. Br Med J. In press.
    1. Rantanen T. Muscle strength, disability and mortality. Scand J Med Sci Sports. 2003;13:3–8. .
    1. Bohannon RW. Hand-grip dynamometry predicts future outcomes in aging adults. J Geriatr Phys Ther. 2008;31:3–10.
    1. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology—a proposal for reporting. JAMA. 2000;283:2008–12. .
    1. Albrand G, Munoz F, Sornay-Rendu E, et al. Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study. Bone. 2003;32:78–85. .
    1. Alfaro-Acha A, Al Snih S, Raji MA, Kuo YF, Markides KS, Ottenbacher KJ. Handgrip strength and cognitive decline in older Mexican Americans. J Gerontol A Biol Sci Med Sci. 2006;61:859–65.
    1. Buchman AS, Wilson RS, Boyle PA, Bienias JL, Bennett DA. Grip strength and the risk of incident Alzheimer's disease. Neuroepidemiology. 2007;29:66–73. .
    1. Cawthon PM, Fullman RL, Marshall L, et al. Physical performance and risk of hip fractures in older men. J Bone Miner Res. 2008;23:1037–44. .
    1. Cesari M, Kritchevsky SB, Penninx BW, et al. Prognostic value of usual gait speed in well-functioning older people—results from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2005;53:1675–80. .
    1. Cesari M, Kritchevsky SB, Newman AB, et al. Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2009;57:251–9. .
    1. Dargent-Molina P, Favier F, Grandjean H, et al. Fall-related factors and risk of hip fracture: the EPIDOS prospective study. Lancet. 1996;348:145–9. .
    1. Dargent-Molina P, Schott AM, Hans D, et al. Separate and combined value of bone mass and gait speed measurements in screening for hip fracture risk: results from the EPIDOS study. Epidemiologie de l'Osteoporose. Osteoporos Int. 1999;9:188–92. .
    1. Finigan J, Greenfield DM, Blumsohn A, et al. Risk factors for vertebral and nonvertebral fracture over 10 years: a population-based study in women. J Bone Miner Res. 2008;23:75–85. .
    1. Karkkainen M, Rikkonen T, Kroger H, et al. Association between functional capacity tests and fractures: an eight-year prospective population-based cohort study. Osteoporos Int. 2008;19:1203–10. .
    1. Lazarus R, Sparrow D, Weiss ST. Handgrip strength and insulin levels: cross-sectional and prospective associations in the Normative Aging Study. Metab Clin Exp. 1997;46:1266–9.
    1. Lee SH, Dargent MP, Breart G. Risk factors for fractures of the proximal humerus: results from the EPIDOS prospective study. J Bone Min Res. 2002;17:817–25. .
    1. McGinn AP, Kaplan RC, Verghese J, et al. Walking speed and risk of incident ischemic stroke among postmenopausal women. Stroke. 2008;39:1233–9. .
    1. Piirtola M, Vahlberg T, Isoaho R, Aarnio P, Kivela SL. Predictors of fractures among the aged: a population-based study with 12-year follow-up in a Finnish municipality. Aging Clin Exp Res. 2008;20:242–52.
    1. Rothman MD, Leo-Summers L, Gill TM. Prognostic significance of potential frailty criteria. J Am Geriatr Soc. 2008;56:2211–6. .
    1. Silventoinen K, Magnusson PK, Tynelius P, Batty GD, Rasmussen F. Association of body size and muscle strength with incidence of coronary heart disease and cerebrovascular diseases: a population-based cohort study of one million Swedish men. Int J Epidemiol. 2009;38:110–8. .
    1. Sirola J, Rikkonen T, Tuppurainen M, Jurvelin JS, Alhava E, Kroger H. Grip strength may facilitate fracture prediction in perimenopausal women with normal BMD: a 15-year population-based study. Calcif Tissue Int. 2008;83:93–100. .
    1. Stel VS, Pluijm SM, Deeg DJ, Smit JH, Bouter LM, Lips P. Functional limitations and poor physical performance as independent risk factors for self-reported fractures in older persons. Osteoporos Int. 2004;15:742–50.
    1. The Newcastle-Ottawa Quality Assessment Scale. 2009. .
    1. Camicioli R, Howieson D, Oken B, Sexton G, Kaye J. Motor slowing precedes cognitive impairment in the oldest old. Neurology. 1998;50:1496–8.
    1. Cummings SR, Nevitt MC, Browner WS. Risk-factors for hip fracture in white women. N Engl J Med. 1995;332:767–73. .
    1. Kelsey JL, Browner WS, Seeley DG, Nevitt MC, Cummings SR. Risk-factors for fractures of the distal forearm and proximal humerus. Am J Epidemiol. 1992;135:477–89.
    1. Manolio TA, Kronmal RA, Burke GL, Oleary DH, Price TR. Short-term predictors of incident stroke in older adults—The Cardiovascular Health Study. Stroke. 1996;27:1479–86.
    1. Wang L, Larson EB, Bowen JD, van Belle G. Performance-based physical function and future dementia in older people. Arch Intern Med. 2006;166:1115–20. .
    1. Woo J, Ho SC, Yu ALM. Walking speed and stride length predicts 36 months dependency, mortality, and institutionalization in Chinese aged 70 and older. J Am Geriatr Soc. 1999;47:1257–60.
    1. Moreland JD, Richardson JA, Goldsmith CH, Clase CM. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2004;52:1121–9. .
    1. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower-extremity function—association with self-reported disability and prediction of mortality and nursing-home admission. J Gerontol. 1994;49:M85–94.
    1. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–56.

Source: PubMed

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