Care transitions in the first 6months following traumatic brain injury: Lessons from the CENTER-TBI study
Ida M H Borgen, Cecilie Røe, Cathrine Brunborg, Olli Tenovuo, Philippe Azouvi, Helen Dawes, Marek Majdan, Jukka Ranta, Martin Rusnak, Eveline J A Wiegers, Cathrine Tverdal, Louis Jacob, Mélanie Cogné, Nicole von Steinbuechel, Nada Andelic, CENTER-TBI participants investigators, Ida M H Borgen, Cecilie Røe, Cathrine Brunborg, Olli Tenovuo, Philippe Azouvi, Helen Dawes, Marek Majdan, Jukka Ranta, Martin Rusnak, Eveline J A Wiegers, Cathrine Tverdal, Louis Jacob, Mélanie Cogné, Nicole von Steinbuechel, Nada Andelic, CENTER-TBI participants investigators
Abstract
Background: No large international studies have investigated care transitions during or after acute hospitalisations for traumatic brain injury (TBI).
Objectives: To characterise various TBI-care pathways and the number of associated transitions during the first 6 months after TBI and to assess the impact of these on functional TBI outcome controlled for demographic and injury-related factors.
Methods: This was a cohort study of patients with TBI admitted to various trauma centres enrolled in the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Number of transitions and specific care pathways were identified. Multiple logistic regression analyses were used to assess the impact of number of transitions and care pathways on functional outcome at 6 months post-injury as assessed by the Glasgow Outcome Scale-Extended (GOSE).
Results: In total, 3133 patients survived the acute TBI-care pathway and had at least one documented in-hospital transition at 6-month follow-up. The median number of transitions was 3 (interquartile range 2-3). The number of transitions did not predict functional outcome at 6 months (odds ratio 1.08, 95% confidence interval 1.09-1.18; P=0.063). A total of 378 different care pathways were identified; 8 were identical for at least 100 patients and characterized as "common pathways". Five of these common care pathways predicted better functional outcomes at 6 months, and the remaining 3 pathways were unrelated to outcome. In both models, increased age, violence as the cause of injury, pre-injury presence of systemic disease, both intracranial and overall injury severity, and regions of Southern/Eastern Europe were associated with unfavourable functional outcomes at 6 months.
Conclusions: A high number of different and complex care pathways was found for patients with TBI, particularly those with severe injuries. This high number and variety of care pathway possibilities indicates a need for standardisation and development of "common data elements for TBI care pathways" for future studies.
Study registration: ClinicalTrials.gov NCT02210221.
Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Source: PubMed