Tadalafil and acetazolamide versus acetazolamide for the prevention of severe high-altitude illness
Eyal Leshem, Yehezkel Caine, Elliot Rosenberg, Yoram Maaravi, Hagai Hermesh, Eli Schwartz, Eyal Leshem, Yehezkel Caine, Elliot Rosenberg, Yoram Maaravi, Hagai Hermesh, Eli Schwartz
Abstract
We report an open-label study comparing tadalafil and acetazolamide (n = 24) versus acetazolamide (n = 27) for prevention of high-altitude illness (HAI) at Mt. Kilimanjaro. Tadalafil group had lower rates of severe HAI compared with controls (4% vs 26%, p = 0.03), mostly because of decreased high-altitude pulmonary edema rates (4% vs 22%, p = 0.06).
© 2012 International Society of Travel Medicine.
Source: PubMed