Time to recovery from severe acute malnutrition and its predictors: a multicentre retrospective follow-up study in Amhara region, north-west Ethiopia

Adhanom Gebreegziabher Baraki, Temesgen Yihunie Akalu, Haileab Fekadu Wolde, Wubet Worku Takele, Worku Nigussu Mamo, Behailu Derseh, Hanna Demelash Desyibelew, Abel Fekadu Dadi, Adhanom Gebreegziabher Baraki, Temesgen Yihunie Akalu, Haileab Fekadu Wolde, Wubet Worku Takele, Worku Nigussu Mamo, Behailu Derseh, Hanna Demelash Desyibelew, Abel Fekadu Dadi

Abstract

Objectives: This study aimed to determine the time to recovery from severe acute malnutrition (SAM) and its predictors in selected public health institutions in Amhara Regional State, Ethiopia.

Design: An institution-based retrospective follow-up study was conducted using data extracted from 1690 patient cards from September 2012 to November 2016.

Setting: Selected government health institutions in the Amhara region, Ethiopia.

Participants: Children treated in therapeutic feeding units for SAM were included.

Outcome measures: Time to recovery from SAM.

Results: One thousand and fifty children have recovered from SAM, 62.13% (95% CI 59.8% to 64.5%). The median time to recovery was 16 days (IQR=11-28). Female gender (adjusted HR (AHR)=0.81, 95% CI 0.67 to 0.98), oedematous malnutrition (AHR=0.74 95% CI 0.59 to 0.93), pneumonia (AHR=0.66, 95% CI 0.53 to 0.83), tuberculosis (AHR=0.53, 95% CI 0.36 to 0.77), HIV/AIDS (AHR=0.47, 95% CI 0.28 to 0.79), anaemia (AHR=0.73, 95% CI 0.60 to 0.89) and receiving vitamin A (AHR=1.43, 95% CI 1.12 to 1.82) were notably associated with time to recovery.

Conclusions: The time to recovery in this study was acceptable but the proportion of recovery was far below the minimum standard. Special emphasis should be given to the prevention and treatment of comorbidities besides the therapeutic feeding. Supplementing vitamin A would also help to improve the recovery rate.

Keywords: Amhara region; severe acute malnutrition; time to recovery.

Conflict of interest statement

Competing interests: None declared.

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Figures

Figure 1
Figure 1
Kaplan-Meier survival estimate for time to recovery among children treated for severe acute malnutrition (SAM in Amhara region, subgrouped by HIV status (2016)).

References

    1. UNICEF Severe acute malnutrition, 2019. Available: [Accessed 20 Aug 2019].
    1. WHO Severe acute malnutrition, 2019. Available:
    1. World Health Organization and UNICEF Community-Based management of severe acute malnutrition: a joint statement by the world Health organization, the world food programme, the United nations system standing Committee on nutrition and the United nations children's fund, 2007.
    1. Shanka NA, Lemma S, Abyu DM. Recovery rate and determinants in treatment of children with severe acute malnutrition using outpatient therapeutic feeding program in Kamba district, South West Ethiopia. J Nutr Disorders Ther 2015;5 10.4172/2161-0509.1000155
    1. Federal Democratic Republic of Ethiopia The cost of hunger in Ethiopia: implications for the growth and transformation of Ethiopia, 2013. Available: [Accessed 21 Aug 2019].
    1. The Sphere Project Humanitarian charter and minimum standards in humanitarian response 2011.
    1. Mekonnen L, et al. Severity of malnutrition and treatment Responsesin Underfive children in Bahir Dar Felegehiwotreferal Hospital Northwest Ethiopia. Aca J Nutr 2013;2:31–8.
    1. Jarso H, Workicho A, Alemseged F. Survival status and predictors of mortality in severely malnourished children admitted to Jimma university specialized Hospital from 2010 to 2012, Jimma, Ethiopia: a retrospective longitudinal study. BMC Pediatr 2015;15:1 10.1186/s12887-015-0398-4
    1. Chane T, Oljira L, Atomesa GE, et al. . Treatment outcome and associated factors among Under-Five children with severe acute malnutrition admitted to therapeutic feeding unit in Woldia Hospital, North Ethiopia. J Nutr Food Sci 2014;04 10.4172/2155-9600.1000329
    1. Teferi E, Lera M, Sita S, et al. . Treatment outcome of children with severe acute malnutrition admitted to therapeutic feeding centers in southern region of Ethiopia. Ethiopian Journal of Health Development 2010;24.
    1. World Health Organization and the United Nations Children's Fund Who child growth standards and the identification of severe acute malnutrition in infants and children. Geneva, 2009.
    1. Ahmed AU, Ahmed TU, Uddin MS, et al. . Outcome of standardized case management of under-5 children with severe acute malnutrition in three hospitals of Dhaka City in Bangladesh. Bangladesh Journal of Child Health 2013;37:5–13. 10.3329/bjch.v37i1.15345
    1. Desyibelew HD, Fekadu A, Woldie H. Recovery rate and associated factors of children age 6 to 59 months admitted with severe acute malnutrition at inpatient unit of Bahir Dar Felege Hiwot referral hospital therapeutic feeding unite, Northwest Ethiopia. PLoS One 2017;12:e0171020 10.1371/journal.pone.0171020
    1. Collins S, Dent N, Binns P, et al. . Management of severe acute malnutrition in children. The Lancet 2006;368:1992–2000. 10.1016/S0140-6736(06)69443-9
    1. Chamois S, Golden M, Grellety Y. Ethiopia protocol for the management of severe acute malnutrition, 2007.
    1. Banbeta A, Seyoum D, Belachew T, et al. . Modeling time-to-cure from severe acute malnutrition: application of various parametric frailty models. Arch Public Health 2015;73:6 10.1186/2049-3258-73-6
    1. Mekuria G, Derese T, Hailu G. Treatment outcome and associated factors of severe acute malnutrition among 6–59 months old children in Debre Markos and Finote Selam hospitals, Northwest Ethiopia: a retrospective cohort study. BMC Nutr 2017;3:42 10.1186/s40795-017-0161-3
    1. Gebremichael DY. Predictors of nutritional recovery time and survival status among children with severe acute malnutrition who have been managed in therapeutic feeding centers, southern Ethiopia: retrospective cohort study. BMC Public Health 2015;15:1 10.1186/s12889-015-2593-5
    1. Mengesha MM, Deyessa N, Tegegne BS, et al. . Treatment outcome and factors affecting time to recovery in children with severe acute malnutrition treated at outpatient therapeutic care program. Glob Health Action 2016;9:30704 10.3402/gha.v9.30704
    1. Gebremichael M, Bezabih AM, Tsadik M. Treatment outcomes and associated risk factors of severely malnourished under five children admitted to therapeutic feeding centers of Mekelle City, Northern Ethiopia. OAlib 2014;01:1–9. 10.4236/oalib.1100446
    1. Moramarco S, Amerio G, Ciarlantini C, et al. . Community-Based management of child malnutrition in Zambia: HIV/AIDS infection and other risk factors on child survival. Int J Environ Res Public Health 2016;13. doi:10.3390/ijerph13070666. [Epub ahead of print: 01 Jul 2016].
    1. Singh K, Badgaiyan N, Ranjan A, et al. . Management of children with severe acute malnutrition: experience of nutrition rehabilitation centers in Uttar Pradesh, India. Indian Pediatr 2014;51:21–5. 10.1007/s13312-014-0328-9
    1. Bachou H, Tylleskär T, Downing R, et al. . Severe malnutrition with and without HIV-1 infection in hospitalised children in Kampala, Uganda: differences in clinical features, haematological findings and CD4+ cell counts. Nutr J 2006;5:27 10.1186/1475-2891-5-27
    1. Macallan DC, tuberculosis Min. Malnutrition in tuberculosis. Diagn Microbiol Infect Dis 1999;34:153–7. 10.1016/S0732-8893(99)00007-3
    1. Ahmed T, Hossain M, Sanin KI. Global burden of maternal and child undernutrition and micronutrient deficiencies. Ann Nutr Metab 2012;61 Suppl 1:8–17. 10.1159/000345165

Source: PubMed

3
Abonnere