Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts

Anita Morandi, David Meyre, Stéphane Lobbens, Ken Kleinman, Marika Kaakinen, Sheryl L Rifas-Shiman, Vincent Vatin, Stefan Gaget, Anneli Pouta, Anna-Liisa Hartikainen, Jaana Laitinen, Aimo Ruokonen, Shikta Das, Anokhi Ali Khan, Paul Elliott, Claudio Maffeis, Matthew W Gillman, Marjo-Riitta Järvelin, Philippe Froguel, Anita Morandi, David Meyre, Stéphane Lobbens, Ken Kleinman, Marika Kaakinen, Sheryl L Rifas-Shiman, Vincent Vatin, Stefan Gaget, Anneli Pouta, Anna-Liisa Hartikainen, Jaana Laitinen, Aimo Ruokonen, Shikta Das, Anokhi Ali Khan, Paul Elliott, Claudio Maffeis, Matthew W Gillman, Marjo-Riitta Järvelin, Philippe Froguel

Abstract

Objectives: Prevention of obesity should start as early as possible after birth. We aimed to build clinically useful equations estimating the risk of later obesity in newborns, as a first step towards focused early prevention against the global obesity epidemic.

Methods: We analyzed the lifetime Northern Finland Birth Cohort 1986 (NFBC1986) (N = 4,032) to draw predictive equations for childhood and adolescent obesity from traditional risk factors (parental BMI, birth weight, maternal gestational weight gain, behaviour and social indicators), and a genetic score built from 39 BMI/obesity-associated polymorphisms. We performed validation analyses in a retrospective cohort of 1,503 Italian children and in a prospective cohort of 1,032 U.S. children.

Results: In the NFBC1986, the cumulative accuracy of traditional risk factors predicting childhood obesity, adolescent obesity, and childhood obesity persistent into adolescence was good: AUROC = 0·78[0·74-0.82], 0·75[0·71-0·79] and 0·85[0·80-0·90] respectively (all p<0·001). Adding the genetic score produced discrimination improvements ≤1%. The NFBC1986 equation for childhood obesity remained acceptably accurate when applied to the Italian and the U.S. cohort (AUROC = 0·70[0·63-0·77] and 0·73[0·67-0·80] respectively) and the two additional equations for childhood obesity newly drawn from the Italian and the U.S. datasets showed good accuracy in respective cohorts (AUROC = 0·74[0·69-0·79] and 0·79[0·73-0·84]) (all p<0·001). The three equations for childhood obesity were converted into simple Excel risk calculators for potential clinical use.

Conclusion: This study provides the first example of handy tools for predicting childhood obesity in newborns by means of easily recorded information, while it shows that currently known genetic variants have very little usefulness for such prediction.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1. Estimates of risk percentages for…
Figure 1. Estimates of risk percentages for childhood obesity for given pairs of parental BMIs according to the NFBC1986 equation.
Estimates are provided for three different combinations of birth weight, maternal professional category, number of household members and maternal gestational smoking, corresponding to three progressively higher risk backgrounds. Grey cells correspond to risk estimates within the highest risk quartile in the overall population.

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