Preventive tuberculosis treatment effect on QuantiFERON TB-Gold in-tube testing in a high tuberculosis-endemic country: A clinical trial
Qingluan Yang, Qiaoling Ruan, Xuefeng Liu, Yaojie Shen, Tian Jiang, Jing Wu, Limin Cai, Kechuan Pan, Miaoyao Lin, Xitian Huang, Lingyun Shao, Wenhong Zhang, Qingluan Yang, Qiaoling Ruan, Xuefeng Liu, Yaojie Shen, Tian Jiang, Jing Wu, Limin Cai, Kechuan Pan, Miaoyao Lin, Xitian Huang, Lingyun Shao, Wenhong Zhang
Abstract
Background: Whether T-cell interferon-γ responses to Mycobacterium tuberculosis-specific antigens can be influenced by tuberculosis preventive treatment in a high-endemic country is uncertain.
Methods: In this prospective, open-label, controlled study, 513 individuals with silicosis were randomly selected for TB preventive treatment with rifapentine and isoniazid or for observation. QuantiFERON-TB Gold in-tube (QFT-GIT) assay was used to measure IFN-γ response to M. tuberculosis antigens at baseline (T0) and at 6 (T1) and 33 (T2) months after completion of therapy.
Results: A total of 220 subjects were included in the final analysis: 105 and 115 in the prevention and observation arms, respectively. The proportions of QFT-GIT reversion from baseline to T1 were similar in the prevention and observation arms (18.4% vs 12.8%, P=0.566). However, reversion from baseline to T2 was more frequent in the prevention arm than in the observation arm, but the difference was not significant (24.2% vs 6.3%, P=0.881). No significant difference was observed in the quantitative responses of QFT-GIT between the two arms during follow-up at T1 (P=0.648) and T2 (P=0.918).
Conclusions: Preventive tuberculosis treatment has no effect on interferon-γ responses measured by serial QFT-GIT assays in a high tuberculosis-endemic country.
Clinical trials registration: http://www.clinicaltrials.gov NCT02430259.
Keywords: QuantiFERON TB-Gold in-tube; Randomized clinical trial; Serial tests; Tuberculosis preventive treatment.
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Source: PubMed