Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony
Chad A Grotegut, Michael J Paglia, Lauren N C Johnson, Betty Thames, Andra H James, Chad A Grotegut, Michael J Paglia, Lauren N C Johnson, Betty Thames, Andra H James
Abstract
Objective: We sought to determine if women with severe postpartum hemorrhage (PPH) secondary to uterine atony received greater amounts of oxytocin during labor compared to women without PPH.
Study design: Subjects with severe PPH secondary to uterine atony, who received a blood transfusion, were compared to matched controls. Total oxytocin exposure was calculated as the area under the concentration curve (mU/min*min). Variables were compared using paired t test, χ², and logistic regression.
Results: Women with severe PPH had a mean oxytocin area under the curve of 10,054 mU compared to 3762 mU in controls (P < .001). After controlling for race, body mass index, admission hematocrit, induction status, magnesium therapy, and chorioamnionitis using logistic regression, oxytocin area under the curve continued to predict severe PPH.
Conclusion: Women with severe PPH secondary to uterine atony were exposed to significantly more oxytocin during labor compared to matched controls.
Copyright © 2011 Mosby, Inc. All rights reserved.
Source: PubMed