Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases

Nguyen Thanh Liem, Vu Duy Chinh, Nguyen Thi Thinh, Ngo Duy Minh, Hoang Minh Duc, Nguyen Thanh Liem, Vu Duy Chinh, Nguyen Thi Thinh, Ngo Duy Minh, Hoang Minh Duc

Abstract

BACKGROUND Bowel dysfunction is observed in 42.2-71.2% of patients with spina bifida. Traditional treatments yield limited results. The objective of this paper is to report on improvement in bowel function in 2 children with spina bifida following bone marrow-derived mononuclear cells transplantation. CASE REPORT Two patients - 14 years old and 11 years old - with bowel dysfunction after myelomeningocele repair underwent 2 BMMNC transplantations without complications. Those patients had normal defecation, assessed through follow-ups of 21 months and 16 months, respectively. CONCLUSIONS BMMNC transplantation can improve bowel function, as demonstrated in 2 patients with spina bifida.

Conflict of interest statement

Conflict of interest: None declared

Conflict of Interests

The authors have declared that no competing interests exist.

Figures

Figure 1.
Figure 1.
MRI shows a low termination of the spinal cord.
Figure 2.
Figure 2.
(A) Pretransplantation cystography of the first patient demonstrates many diverticula. (B) Post-transplantation cystography of the first patient still shows many diverticula.
Figure 3.
Figure 3.
(A) Pre-transplantation urodynamic investigation of the first patient reveals a very underactive detrusor function. (B) Post-transplantation urodynamic investigation of the first patient shows increased detrusor function.
Figure 4.
Figure 4.
Flow cytometry of CD34+ analysis of the first patient. Calculation of CD34+ population from the BMMNCs at the 1st transplantation (A) and 2nd transplantation (B).
Figure 5.
Figure 5.
Spinal MRI of the second patient demonstrates a low termination of the spinal cord.
Figure 6.
Figure 6.
(A) Pre-transplantation cystography of the second patient shows multiple diverticula. (B) Post-transplantation cystography of the second patients still shows multiple diverticula.
Figure 7.
Figure 7.
(A) Pre-transplantation urodynamic investigation of the second patient shows hyperactive detrusor functions. (B) Post-transplantation urodynamic investigation of the second patient reveals reduced hyperactive detrusor function.
Figure 8.
Figure 8.
Flow cytometry of CD34+ analysis of the second patient. Calculation of the CD34+ population from the BMMNCs at the 1st transplantation (A) and 2nd transplantation (B).

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