Geriatric Anesthesia-related Morbidity and Mortality in China: Current Status and Trend

Yang Liu, Wei Xiao, Ling-Zhong Meng, Tian-Long Wang, Yang Liu, Wei Xiao, Ling-Zhong Meng, Tian-Long Wang

Abstract

Objective: The population of elderly patients and the amount of geriatric anesthesia have been growing rapidly in China. Thus, understanding the morbidity and mortality associated with geriatric anesthesia in China is critical to the improvement of anesthesia quality and outcome. The aim of the review was to discuss the geriatric anesthesia-related morbidity and mortality in China, as well as to point out the future trend.

Data sources: Articles in this review were all searched from Wanfang, China National Knowledge Infrastructure (CNKI), VIP, PubMed, and Web of Science databases, based on the reports originated in China from January 2011 to December 2016.

Study selection: A total of 57 studies were selected for further study, including 12 retrospective studies, 35 prospective studies, 3 meta-analyses, 4 reviews, 1 viewpoint, and 2 case reports. Of the total studies, 42 studies were in Chinese while 15 were in English.

Results: The mortality and morbidity associated with geriatric anesthesia in China are not yet completely reported. Some factors have been recognized, while some are yet to be identified and confirmed. Several studies addressed postoperative cognitive dysfunction and postoperative delirium, whereas only a few studies can be found on renal complications. Thus, a nationwide registry is essential for geriatric anesthesia-associated adverse outcomes. The mortality associated with geriatric anesthesia in China should be reported promptly. In the future, the perspective of geriatric anesthesia needs to be expanded into perioperative geriatric medicine to improve the perioperative management strategy based on the postoperative outcome-directed concept transformation.

Conclusions: Anesthesiologists should evaluate the physiological and medical status and focus on the prevention of potential complications in the perioperative setting with the goal to enhance elderly patients' long-term well-being and survival quality.

Conflict of interest statement

There are no conflicts of interest.

References

    1. Wang Y, Zhao SX, Zeng EK, Ma CW, Wang JY, Duan L. The social development and the coping strategies for China's aging population (In Chinese) Chin J Soc Med. 2014;31:75–7. doi: 10.3969/j.issn.1673-5625.2014.02.001.
    1. Su WY. The characteristics of medication in elderly patients and the principles of rational drug application (In Chinese) J Pract Med. 2008;15:3957–8. doi: 10.3969/j.issn.1671-5098.2008.28.132.
    1. Song K, Rong Z, Yang XF, Yao Y, Shen YS, Shi DQ, et al. Early pulmonary complications following total knee arthroplasty under general anesthesia: A prospective cohort study using CT scan. Biomed Res Int. 2016;2016:1–5. doi: 10.1155/2016/4062043.
    1. Jiao Y. The analysis of pulmonary infection in patients undergoing abdominal surgery after general anesthesia (In Chinese) Chin J Gerontol. 2013;33:4065–6. doi: 10.3969/j.issn.1005-9202.2013.16.134.
    1. Liu N, Piao MH, Wang YS, Ma HC, Yue Y, Feng CS. Risk factors for postoperative respiratory complications and establishment of a preoperative risk scoring system (In Chinese) Chin J Anesthesiol. 2013;33:810–4. doi: 10.3760/cma.j.issn.0254-1416.2013.07.008.
    1. Wei B, Zhang H, Wang J, Zhang LP, Guo XY, Li M, et al. Effects of general anesthesia and combined spinal epidural anesthesia on postoperative pulmonary complications after hip fracture surgery in elderly patients: A multiple factors analysis (In Chinese) Chin J Min Inv Surg. 2015;15:289–92. doi: 10.3969/j.issn.1009-6604.2015.04.001.
    1. Zhang Y, Xie YY, Yu JS. The effects of different anesthesia methods on postoperative pulmonary complications in senile patients undergoing lower limb orthopedic surgery (In Chinese) J Pract Med. 2015;31:1152–4. doi: 10.3969/j.issn.1006-5725.2015.07.036.
    1. Xu Q, Zhang H, Zhu YM, Shi NJ. Effects of combined general/epidural anesthesia on hemodynamics, respiratory function, and stress hormone levels in patients with ovarian neoplasm undergoing laparoscopy. Med Sci Monit. 2016;22:4238–46. doi: 10.12659/msm.897430.
    1. Xu X, Yang X, Li S, Luo M, Qing Y, Zhou X, et al. Risk factors of lower respiratory tract infection in patients after tracheal intubation under general anesthesia in the Chinese health care system: A meta-analysis. Am J Infect Control. 2016;44:e215–20. doi: 10.1016/j.ajic.2016.07.010.
    1. Wang JG, He LL, Liu HJ, Wang W, Weng H, Wang F, et al. Efficacy of laryngeal mask airway supreme in elderly patients with hypertension (In Chinese) Chin J Anesthesiol. 2012;32:1043–6. doi: 10.3760/cma.j.issn.0254-1416.2012.09.003.
    1. Lu J, Zhou HM, Zhu ZP, Du YF, Zhou QH, Xiao WP. Effects of remote ischemic preconditioning combined with dexmedetomidine on lung injury during perioperative period and postoperative pulmonary complications in elderly patients with thoracotomy and pulmonary dysfunction (In Chinese) Chin J Geriatr. 2016;35:381–6. doi: 10.3760/cma.j.issn.0254-1416.2014.11.002.
    1. Zhang W, Zhang JQ, Meng FM. Effect of dexmedetomidine combined with continuous positive airway pressure on oxidative stress and inflammatory responses during one-lung ventilation in elderly patients undergoing radical surgery for esophageal carcinoma (In Chinese) Chin J Anesthesiol. 2014;34:5–8. doi: 10.3760/cma.j.issn.0254-1416.2014.01.002.
    1. Xue F, Zhu HC, Zhang W. The efficacy of the dexmedetomidine in preventing pulmonary complication in elderly patients receiving non-extracorporeal circulation coronary artery bypass graft surgery (In Chinese) Chin J Anesthesiol. 2014;34:1407–8. doi: 10.3760/cmaj.issn.0254-1416.2014.11.035.
    1. Ye H, Qiu XD, Jing L. Effects of norepinephrine on oxygen metabolism and postoperative outcomes in elderly patients undergoing fluid-restricted abdominal surgery (In Chinese) Chin J Anesthesiol. 2012;32:690–4. doi: 10.3760/cma.j.issn.0254-1416.2012.06.011.
    1. Zhao GL, Zhou YY, Peng PH, Chen WD, Li JM, Shao JL, et al. Effect of goal-directed fluid therapy on postoperative rehabilitation in elderly patients undergoing resection of gastrointestinal tumor (In Chinese) Chin J Anesthesiol. 2015;35:453–6. doi: 10.3760/cma.j.issn.0254-1416.2015.04.017.
    1. Ge YY, Yuan LY, Jiang XH, Wang XZ, Xu RM, Ma WH. Effect of lung protection mechanical ventilation on respiratory function in the elderly undergoing spinal fusion (In Chinese) J Cent South Univ (Med Sci) 2013;38:81–5. doi: 10.3969/j.issn.1672-7347.2013.015.
    1. Ji W, Kong L, Meng XR, Li DG. The clinic comparison of dezocine and sufentanil in elderly patients undergoing hysteroscopic removal of intrauterine device (In Chinese) Int J Anesth Resusc. 2016;37:18–21. doi: 10.3760/cma.j.issn.1673-4378.2016.01.005.
    1. Liu Y, Chen LP, Gao Y, Zhou H. Effects of smoking on pulmonary function in middle aged and elderly patients (In Chinese) Chin J Gerontol. 2013;33:4247–8. doi: 10.3969/j.issn.1005-9202.2013.17.068.
    1. Bulka CM, Terekhov MA, Martin BJ, Dmochowski RR, Hayes RM, Ehrenfeld JM. Nondepolarizing neuromuscular blocking agents, reversal, and risk of postoperative pneumonia. Anesthesiology. 2016;125:647–55. doi: 10.1097/ALN.0000000000001279.
    1. Xie XY. Effect of general anesthesia combined with epidural anesthesia on pulmonary function in elderly patients undergoing thoracic surgery (In Chinese) Zhejiang J Traumat Surg. 2016;21:796–7. doi: 10.3969/j.issn.1009-7147.2016.04.091.
    1. Cui Y, Ding Y, Chen L, Li Y, Li YC, Nie H. Dexmedetomidine enhances human lung fluid clearance through improving alveolar sodium transport. Fundam Clin Pharmacol. 2017;31:429–37. doi: 10.1111/fcp.12278.
    1. Li N, Ouyang BS, Liu L, Lin CS, Xing DD, Liu J. Dexmedetomidine protected COPD-induced lung injury by regulating miRNA-146a. Bratisl Lek Listy. 2016;117:539–42. doi: 10.4149/bll_2016_106.
    1. Bi GY, Wang SY, Yang SH. Effect of penehyclidine hydrochloride as premedication of epidural anesthesia on postoperative cognitive dysfunction in elderly patients (In Chinese) Chin J Med Guide. 2012;14:47–8. doi: 10.3969/j.issn.1009-0959.2012.01.030.
    1. Luo J, Deng XY. The effect of different anesthetic method on postoperative cognitive dysfunction in elderly patients with hip fracture (In Chinese) Chin J Trauma. 2016;32:327–8. doi: 10.3760/cma.j.issn.1001-8050.2016.04.011.
    1. Zhang FX, Ning JP, Qiu B, Wang SP, He CJ. Comparison of occurrence of postoperative cognitive dysfunction in elderly patients using different anesthetic methods (In Chinese) Chin J Anesthesiol. 2013;33:188–90. doi: 10.3760/cma.j.issn.0254-1416.2013.02.014.
    1. Chen ZW, Ding SC, Zhang L. Risk factors for postoperative cognitive dysfunction in elderly patients requiring general anesthesia (In Chinese) Chin J Anesthesiol. 2013;33:31–3. doi: 10.3760/cma.j.issn.0254-1416.2013.01.006.
    1. Peng XQ, Liu ZQ, Wu L, Ou BB, Liang HT, Zhang XX. Risk factors for early postoperative cognitive dysfunction in elderly patients undergoing spinal surgery (In Chinese) Chin J Anesthesiol. 2012;32:939–41. doi: 10.3760/cma.j.issn.0254-1416.2012.08.010.
    1. Song FX, Zhu HY, Hou LN, Li JJ, Deng LQ, Zhao HY. Effects of the second total knee replacement on early postoperative cognitive function in elderly patients (In Chinese) Int J Anesth Resusc. 2016;37:193–6. doi: 10.3760/cma.j.issn.1673-4378.2016.03.001.
    1. Sun DF, Yang L, Wei B, Liu RC, Wang LJ, Qiu B. Effects of dopamine intravenous infusion on postoperative cognitive dysfunction in elderly patients receiving hip joint replacement surgery (In Chinese) Chin J Anesthesiol. 2012;32:1149–50. doi: 10.3760/cma.j.issn.0254-1416.2012.09.034.
    1. Ge YL, Long FY, Guo F, Fang XZ, Gao J. Effects of dexmedetomidine on postoperative cognitive function in aged patients undergoing carotid endarterectomy (In Chinese) Chin J Anesthesiol. 2014;34:1303–5. doi: 10.3760/cma.j.issn.0254-1416.2014.11.004.
    1. Tan HL, Xu L, Shi HW, Wei HY, Ge YL. Effects of dexmedetomidine on postoperative cognitive function in elderly patients undergoing coronary artery bypass graft surgery (In Chinese) Int J Anesth Resusc. 2015;36:481–4. doi: 10.3760/cma.j.issn.1673-4378.2015.06.001.
    1. Chen JJ, Yan JQ, Han XP. Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients (In Chinese) Exp Ther Med. 2013;5:489–94. doi: 10.3892/etm.2012.811.
    1. Lei J, Tang GX, Saleh AJ, Chen J, Peng LY, Chen ZF, et al. Effect of memory training using the “method of loci” before operation on early postoperative cognitive function in elderly patients undergoing laparotomy under general anesthesia (In Chinese) Chin J Anesthesiol. 2014;34:525–8. doi: 10.3760/cma.j.issn.0254-1416.2014.05.001.
    1. Yon JH, Daniel-Johnson J, Carter LB, Jevtovic-Todorovic V. Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways. Neuroscience. 2005;135:815–27. doi: 10.1016/j.neuroscience.2005.03.064.
    1. Minkova L, Habich A, Peter J, Kaller CP, Eickhoff SB, Klöppel S. Gray matter asymmetries in aging and neurodegeneration: A review and meta-analysis. Hum Brain Mapp. 2017 [Epub ahead of print] doi: 10.1002/hbm.23772.
    1. Paeschke N, von Haefen C, Endesfelder S, Sifringer M, Spies CD. Dexmedetomidine prevents lipopolysaccharide-induced microRNA expression in the adult rat brain. Int J Mol Sci. 2017;18 pii: E1830. doi: 10.3390/ijms18091830.
    1. Yamanaka D, Kawano T, Nishigaki A, Aoyama B, Tateiwa H, Shigematsu-Locatelli M, et al. Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats. J Anesth. 2017;31:25–35. doi: 10.1007/s00540-016-2264-4.
    1. Zhang H, Lu Y, Liu M, Zou Z, Wang L, Xu FY, et al. Strategies for prevention of postoperative delirium: A systematic review and meta-analysis of randomized trials. Crit Care. 2013;17:R47. doi: 10.1186/cc12566.
    1. Yuan XL, Jiang ZX, Song LX, Yang L, He Y, Luo GY. Risk factors of postoperative delirium in elderly patients in China: A systematic review (In Chinese) Chin Gen Pract. 2015;18:1197–202. doi: 10.3969/j.issn.1007-9572.2015.10.024.
    1. Guo Y, Jia PY, Zhang JF, Wang XM, Jiang H, Jiang W. Prevalence and risk factors of postoperative delirium in elderly hip fracture patients. J Int Med Res. 2016;44:317–27. doi: 10.1177/0300060515624936.
    1. Zhou XM, Zhang MH, Xu KZ. Effects of dexmedetomidine on delirium in elderly patients undergoing ovarian cancer resection surgery during recovery (In Chinese) Chin J Gerontol. 2016;36:3243–4. doi: 10.3969/j.issn.1005-9202.2016.13.072.
    1. Zhou J, Wang L, Guo Y, Zhou Q. Effects of dexmedetomidine and midazolam on postoperative delirium in elderly patients: A systematic review (In Chinese) Hainan Med J. 2015;26:277–80. doi: 10.3969/j.issn.1003-6350.2015.02.0098.
    1. Ji J, Fu L, Guo X. Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after laparoscopic surgery (In Chinese) J Chin Physician. 2016;18:1017–20. doi: 10.3760/cma.j.issn.1008-1372.2016.07.016.
    1. Li H, Li Q, Yang FF, Hou B, Zheng YF, Feng SQ. The study of multimodal analgesia on postoperative delirium in elder patients with hip fracture (In Chinese) Chin J Orthop. 2013;33:736–40. doi: 10.3760/cma.j.issn.0253-2352.2013.07.009.
    1. Ma CY. Effects of dexmedetomidine on postoperative delirium in elderly patients with severe diseases (In Chinese) Chin J Geriatr. 2015;34:141–3. doi: 10.3760/cma.j.issn.0254-9026.2015.02.008.
    1. Zhang CH, Ma WQ, Yang YL, Wang HM, Dong FT, Xi X, et al. Effect of dexmedetomidine combined anesthesia on postoperative delirium in elderly patients undergoing hip joint replacement (In Chinese) Chin J Anesthesiol. 2012;32:936–8. doi: 10.3760/cma.j.issn.0254-1416.2012.08.009.
    1. Chen JZ, Lin CZ. The effect of dexmedetomidine on postoperative delirium in elderly patients undergoing TURP (In Chinese) Chin J Gerontol. 2012;32:4749–51. doi: 10.3969/j.issn.1005-9202.2012.21.069.
    1. Xia YJ, Bai YF, Lei Q, Xu F, Liu Y, Tian YJ, et al. Effects of different dose of dexmedetomidine on postoperative delirium from general anaesthesia undergoing hip-replacement surgery in aged hypertensive patients (In Chinese) Int J Anesth Resusc. 2016;37:225–9. doi: 10.3760/cma.j.issn.1673-4378.2016.03.009.
    1. Zeng QL, Tang PG, Xu YX, Liang YS. Effect of limited blood transfusion and open blood transfusion on postoperative delirium in elderly patients undergoing hip arthroplasty (In Chinese) Chin J Gerontol. 2016;36:1667–8. doi: 10.3969/j.issn.1005-9202.2016.07.060.
    1. Li N, Xu XF. The progress of postoperative delirium in elderly patients (In Chinese) Chin J Gerontol. 2008;28:1867–9. doi: 10.3969/j.issn.1005-9202.2008.18.052.
    1. Gosch M, Nicholas JA. Pharmacologic prevention of postoperative delirium. Z Gerontol Geriatr. 2014;47:105–9. doi: 10.1007/s00391-013-0598-1.
    1. Colon E, Bittner EA, Kussman B, McCann ME, Soriano S, Borsook D. Anesthesia, brain changes, and behavior: Insights from neural systems biology. Prog Neurobiol. 2017;153:121–60. doi: 10.1016/j.pneurobio.2017.01.005.
    1. Robertson BD, Robertson TJ. Postoperative delirium after hip fracture. J Bone Joint Surg Am. 2006;88:2060–8. doi: 10.2106/JBJS.F.00049.
    1. Rana MV, Bonasera LK, Bordelon GJ. Pharmacologic considerations of anesthetic agents in geriatric patients. Anesthesiol Clin. 2017;35:259–71. doi: 10.1016/j.anclin.2017.01.011.
    1. Chrysostomou C, Schmitt C. Dexmedetomidine sedation, analgesia and beyond. Expert Opin Drug Metab Toxicol. 2008;4:619–27. doi: 10.1517/17425255.4.5.619.
    1. Liu ZJ, Yu CH, Xu L, Luo AL, Huang YG. Risk factors for perioperative major adverse cardiac events in elderly patients with coronary heart disease undergoing orthopedic surgery (In Chinese) Chin J Anesthesiol. 2013;33:402–5. doi: 10.3760/cma.j.issn.0254-1416.2013.04.002.
    1. Zhang JR, Wang ZQ, Ji Y, Qian HD, Dong N. Risk analysis of cardiovascular events in elderly hypertensive patients with different risk stratification during the perioperative period (In Chinese) Natl Med J Chin. 2015;95:2258–63. doi: 10.3760/cma.j.issn.0376-2491.2015.28.004.
    1. Shan XS, Ma CY, Cai S, Cheng H, Ji FH. The anesthesia management in percutaneous aortic valve replacement (In Chinese) Chin J Anesthesiol. 2015;35:636–8. doi: 10.3760/cma.j.issn.0254.1416.2015.05.031.
    1. Mou Y, Wang M, Chai YR, Luo CD, Liu YB, Dai M. Effects of anxiety and depression on adiponectin and endothelial function in patients with coronary artery disease (In Chinese) Chin J Integr Med Cardio. 2016;14:52–4. doi: 10.3969/j.issn.1672-1349.2016.01.015.
    1. Lu Y, Yu JM, Dong CS, Liu Q, Li L, Xu RH. Effects of dexmedetomidine on quality of emergence from general anesthesia in elderly patients undergoing orthopedic operation (In Chinese) Chin J Anesthesiol. 2012;32:742–4. doi: 10.3760/cma.j.issn.0254-1416.2012.06.027.
    1. Lv Y, Han CY, Ma HC, Wang HS. The protective effect of dexmedetomidine on myocardium in elderly patients with coronary heart disease undergoing noncardiac surgery (In Chinese) Chin J Lab Diagn. 2013;17:368–9. doi: 10.3969/j.issn.1007-4287.2013.02.062.
    1. Li YH, Wang TL, Zhao L. Clinical research of goal-directed fluid management based on the cardiac index/stroke volume index/stroke volume variation in geriatric patients undergoing thoracic lobectomy (In Chinese) Int J Anesth Resusc. 2013;34:385–9. doi: 10.3760/cma.j.issn.1673-4378.2013.05.001.
    1. Zeng K, Li YZ, Liang M, Gao YG, Cai HD, Lin CZ. The influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery. Drug Des Devel Ther. 2014;8:2113–9. doi: 10.2147/DDDT.S66724.
    1. Liu LL, Li DY, Sun H, Xu ZX. The effect of throat superficial anesthesia on the hemodynamics in elderly patients during anesthesia induction (In Chinese) Chin J Gerontol. 2017;37:2237–8. doi: 10.3969/j.issn.1005-9202.2017.09.072.
    1. Liu P, Zheng JG. Blood pressure targets in the hypertensive elderly. Chin Med J. 2017;130:1968–72. doi: 10.4103/0366-6999.211885.
    1. Li YS. Perioperative goal-directed fluid therapy: Grand progress and controversy (In Chinese) Chin J Gastrointest Surg. 2012;15:540–3. doi: 10.3760/cma.j.issn.1671-0274.2012.06.003.
    1. Yong FF, Li C, Du W, Zhu KS, Liu W, Jia HQ. The progress of goal directed liquid treatment in elderly patients during perioperative period (In Chinese) Int J Anesth Resusc. 2016;37:741–5. doi: 10.3760/cma.j.issn.1673-4378.2016.08.017.
    1. Hu PH, Chen YH, Liang XL, Li RL, Li ZL, Jiang F, et al. Effect of early postoperative use of ACEI/ARB or diuretics on the incidence of acute kidney injury after cardiac surgery in elderly patients (In Chinese) Chin Crit Care Med. 2013;25:394–8. doi: 10.3760/cma.j.issn.2095-4352.2013.07.005.
    1. Xu JQ, Chen YH, Liang XL, Hu PH, Cai L, An SL, et al. Impact of pre-operative uric acid on acute kidney injury after cardiac surgery in elderly patients (In Chinese) Chin J Cardiol. 2014;42:922–6. doi: 10.3760/cma.j.issn.0253-3758.2014.11.010.
    1. Zhang Y, Zhao YC, Pan XC. The early diagnosis of renal damage following mannitol therapy in cerebral hemorrhage patients (In Chinese) J Clin Exp Med. 2012;11:737–9. doi: 10.3969/j.issn.1671-4695.2012.10.004.
    1. Li Y. The mechanism of the diuretic aggravating acute kidney injury (In Chinese) J Clin Nephrol. 2012;12:153–4. doi: 10.3969/j.issn.1671-2390.2012.04.003.
    1. Lv SG, Yang TJ, Li CS, Li TK, Wang L, Sun YL, et al. Comparison of kidney injury in diabetic patients undergoing liver cancer resection performed under different methods of anesthesia (In Chinese) Chin J Anesthesiol. 2014;34:1073–5. doi: 10.3760/cma.j.issn.0254-1416.2014.09.011.
    1. Xu WT, Yu WL, Du HY. Comparison of kidney injury following liver transplantation performed under propofol versus sevoflurane combined anesthesia (In Chinese) Chin J Anesthesiol. 2012;32:1246–8. doi: 10.3760/cma.j.issn.0254-1416.2012.10.024.
    1. Liu J. My view on the development of the Chinese anesthesiology in the near future (In Chinese) Chin J Anesthesiol. 2015;35:13–5. doi: 10.3760/cma.j.issn.0254-1416.2015.01.005.
    1. Sun Q, Tong PJ, Xu BB, Lv SJ, Yang L, Huang YL, et al. Risk factors for 1-year mortality in elderly patients after intertrochanteric fracture surgery: A retrospective study of 1854 case (In Chinese) Chin J Orthop Trauma. 2013;15:371–6. doi: 10.3760/cma.j.issn.1671-7600.2013.05.002.
    1. Li SG, Sun TS, Liu Z, Ren JX, Liu B, Gao Y. Factors influencing postoperative mortality one year after surgery for hip fracture in Chinese elderly population. Chin Med J. 2013;26:2715–9. doi: 10.3760/cma.j.issn.0366-6999.20122986.
    1. Li SG, Liu Z, Sun TS, Ren JX. The postoperative mortality of one year after surgery for hip fracture in elderly population and risk factors analysis (In Chinese) Beijing Med J. 2015;37:1031–5. doi: 10.15932/j.0253-9713.2015.11.005.
    1. Feng ML, Shen HL. Predictors of one year mortality in the elderly patients with hip fracture following poststroke hemiplegia (In Chinese) Chin J Orthop Trauma. 2012;14:93–7. doi: 10.3760/cma.j.issn.1671-7600.2012.02.001.
    1. Lin L, Liu C, Tan H, Ouyang H, Zhang Y, Zeng W. Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: A retrospective analysis. Br J Anaesth. 2011;106:814–22. doi: 10.1093/bja/aer055.
    1. Liu JL, Wang XL, Gong MW, Mai HX, Pei SJ, Yuan WX, et al. Comparative outcomes of peripheral nerve blocks versus general anesthesia for hip fractures in geriatric Chinese patients. Patient Prefer Adherence. 2014;8:651–9. doi: 10.2147/PPA.S61903.
    1. Yu HC, Luo YX, Peng H, Wang XL, Yang ZH, Huang MJ, et al. Association of perioperative blood pressure with long-term survival in rectal cancer patients. Chin J Cancer. 2016;35:1–10. doi: 10.1186/s40880-016-0100-8.
    1. Pei LJ, Tan G, Wang L, Guo WJ, Xiao B, Gao XL, et al. Comparison of combined general-epidural anesthesia with general anesthesia effects on survival and cancer recurrence: A meta-analysis of retrospective and prospective studies. PloS One. 2014;9:e114667. doi: 10.1371/journal.pone.0114667.
    1. Liu Y, Xiong LZ. Perioperative medicine is the direction of the development of anesthesiology (In Chinese) Chin J Anesthesiol. 2016;36:3–4. doi: 10.3760/cma.j.issn.0254-1416.2016.01.002.
    1. Grocott MP, Mythen MG. Perioperative medicine: The value proposition for anesthesia? A UK perspective on delivering value from anesthesiology. Anesthesiol Clin. 2015;33:617–28. doi: 10.1016/j.anclin.2015.07.003.
    1. Wang TL, Wang DX. Promoting the transformation of the Chinese geriatric anesthesia into perioperative geriatric medicine (In Chinese) Natl Med J Chin. 2016;96:3441–2. doi: 10.3760/cma.j.issn.0376-2491.2016.43.001.
    1. Gu J, Xu K, Ning J, Yi B, Lu K. GlideScope-assisted fiberoptic bronchoscope intubation in a patient with severe rheumatoid arthritis. Acta Anaesthesiol Taiwan. 2014;52:85–7. doi: 10.1016/j.aat.2014.04.002.
    1. Yu B, He M, Cai GY, Zou TX, Zhang N. Ultrasound-guided continuous femoral nerve block vs. continuous fascia iliaca compartment block for hip replacement in the elderly: A randomized controlled clinical trial (CONSORT) Medicine. 2016;95:e5056. doi: 10.1097/MD.0000000000005056.
    1. Zhang XF, Xu MY. The clinical application and function expansion of anesthesia information management system (In Chinese) Chin J Hosp Admin. 2007;23:558–9. doi: 10.3760/j.issn:1000-6672.2007.08.019.

Source: PubMed

3
Abonnere