Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption

Theodore J Angelopoulos, Joshua Lowndes, Stephanie Sinnett, James M Rippe, Theodore J Angelopoulos, Joshua Lowndes, Stephanie Sinnett, James M Rippe

Abstract

The impact of fructose, commonly consumed with sugars by humans, on blood pressure and uric acid has yet to be defined. A total of 267 weight-stable participants drank sugar-sweetened milk every day for 10 weeks as part of their usual, mixed-nutrient diet. Groups 1 and 2 had 9% estimated caloric intake from fructose or glucose, respectively, added to milk. Groups 3 and 4 had 18% of estimated caloric intake from high fructose corn syrup or sucrose, respectively, added to the milk. Blood pressure and uric acid were determined prior to and after the 10-week intervention. There was no effect of sugar type on either blood pressure or uric acid (interaction P>.05), and a significant time effect for blood pressure was noted (P<.05). The authors conclude that 10 weeks of consumption of fructose at the 50th percentile level, whether consumed as pure fructose or with fructose-glucose-containing sugars, does not promote hyperuricemia or increase blood pressure.

Trial registration: ClinicalTrials.gov NCT01797042.

© 2014 Wiley Periodicals, Inc.

Figures

Figure 1
Figure 1
Study schematic. BMI indicates body mass index; PI, principal investigator.
Figure 2
Figure 2
Entire day (23‐hour) area under the curve (AUC) for uric acid under standardized feeding conditions. HFCS indicates high fructose corn syrup.

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