Host factors and portal of entry outweigh bacterial determinants to predict the severity of Escherichia coli bacteremia
Agnès Lefort, Xavière Panhard, Olivier Clermont, Paul-Louis Woerther, Catherine Branger, France Mentré, Bruno Fantin, Michel Wolff, Erick Denamur, COLIBAFI Group, Michel Wolff, Loubna Alavoine, Xavier Duval, David Skurnik, Paul-Louis Woerther, Antoine Andremont, Etienne Carbonnelle, Olivier Lortholary, Xavier Nassif, Sophie Abgrall, Françoise Jaureguy, Bertrand Picard, Véronique Houdouin, Yannick Aujard, Stéphane Bonacorsi, Edouard Bingen, Agnès Meybeck, Guilène Barnaud, Catherine Branger, Agnès Lefort, Bruno Fantin, Claire Bellier, Frédéric Bert, Marie-Hélène Nicolas-Chanoine, Bernard Page, Julie Cremniter, Jean-Louis Gaillard, Bernard Garo, Séverine Ansart, Geneviève Herry-Arnaud, Didier Tandé, Jean-Claude Renet, René Ze Bekolo, Renaud Verdon, Roland Leclercq, Claire de Gialluly, Jean-Marc Besnier, Laurent Mereghetti, Roland Quentin, Achille Kouatchet, Alain Mercat, Marie Laure Joly-Guillou, Catherine Dalebroux, Pascal Chavanet, Catherine Neuwirth, Camille Colliard, Martin Dary, Gilles Potel, Jocelyne Caillon, Françoise Leturdu, Jean-Pierre Sollet, Gaëtan Plantefève, Agnès de Patureaux, Pierre Tattevin, Pierre-Yves Donnio, Erick Denamur, Olivier Clermont, Christine Amorin, Jeremy Glodt, Xavière Panhard, Ludovic Lassel, Quentin Dornic, France Mentré, Estelle Marcault, Florence Tubach, Agnès Lefort, Xavière Panhard, Olivier Clermont, Paul-Louis Woerther, Catherine Branger, France Mentré, Bruno Fantin, Michel Wolff, Erick Denamur, COLIBAFI Group, Michel Wolff, Loubna Alavoine, Xavier Duval, David Skurnik, Paul-Louis Woerther, Antoine Andremont, Etienne Carbonnelle, Olivier Lortholary, Xavier Nassif, Sophie Abgrall, Françoise Jaureguy, Bertrand Picard, Véronique Houdouin, Yannick Aujard, Stéphane Bonacorsi, Edouard Bingen, Agnès Meybeck, Guilène Barnaud, Catherine Branger, Agnès Lefort, Bruno Fantin, Claire Bellier, Frédéric Bert, Marie-Hélène Nicolas-Chanoine, Bernard Page, Julie Cremniter, Jean-Louis Gaillard, Bernard Garo, Séverine Ansart, Geneviève Herry-Arnaud, Didier Tandé, Jean-Claude Renet, René Ze Bekolo, Renaud Verdon, Roland Leclercq, Claire de Gialluly, Jean-Marc Besnier, Laurent Mereghetti, Roland Quentin, Achille Kouatchet, Alain Mercat, Marie Laure Joly-Guillou, Catherine Dalebroux, Pascal Chavanet, Catherine Neuwirth, Camille Colliard, Martin Dary, Gilles Potel, Jocelyne Caillon, Françoise Leturdu, Jean-Pierre Sollet, Gaëtan Plantefève, Agnès de Patureaux, Pierre Tattevin, Pierre-Yves Donnio, Erick Denamur, Olivier Clermont, Christine Amorin, Jeremy Glodt, Xavière Panhard, Ludovic Lassel, Quentin Dornic, France Mentré, Estelle Marcault, Florence Tubach
Abstract
Escherichia coli ranks among the organisms most frequently isolated from cases of bacteremia. The relative contribution of the host and bacteria to E. coli bacteremia severity remains unknown. We conducted a prospective multicenter cohort study to identify host and bacterial factors associated with E. coli bacteremia severity. The primary endpoint was in-hospital death, up to 28 days after the first positive blood culture. Among 1,051 patients included, 136 (12.9%) died. Overall, 604 (57.5%) patients were female. The median age was 70 years, and 202 (19.2%) episodes were nosocomial. The most frequent comorbidities were immunocompromised status (37.9%), tobacco addiction (21.5%), and diabetes mellitus (20.1%). The most common portal of entry was the urinary tract (56.9%). Most E. coli isolates belonged to phylogenetic group B2 (52.0%). The multivariate analysis retained the following factors as predictive of death: older age (odds ratio [OR] = 1.25 [95% confidence interval {CI}, 1.09 to 1.43] for each 10-year increment), cirrhosis (OR = 4.85 [95% CI, 2.49 to 9.45]), hospitalization before bacteremia (OR = 4.13 [95% CI, 2.49 to 6.82]), being an immunocompromised patient not hospitalized before bacteremia (OR = 3.73 [95% CI, 2.25 to 6.18]), and a cutaneous portal of entry (OR = 6.45 [95% CI, 1.68 to 24.79]); a urinary tract portal of entry and the presence of the ireA virulence gene were negatively correlated with death (OR = 0.46 [95% CI, 0.30 to 0.70] and OR = 0.53 [95% CI, 0.30 to 0.91], respectively). In summary, host factors and the portal of entry outweigh bacterial determinants for predicting E. coli bacteremia severity.
Figures
Source: PubMed