Change in fracture risk and fracture pattern after bariatric surgery: nested case-control study

Catherine Rousseau, Sonia Jean, Philippe Gamache, Stéfane Lebel, Fabrice Mac-Way, Laurent Biertho, Laëtitia Michou, Claudia Gagnon, Catherine Rousseau, Sonia Jean, Philippe Gamache, Stéfane Lebel, Fabrice Mac-Way, Laurent Biertho, Laëtitia Michou, Claudia Gagnon

Abstract

Objective: To investigate whether bariatric surgery increases the risk of fracture.

Design: Retrospective nested case-control study.

Setting: Patients who underwent bariatric surgery in the province of Quebec, Canada, between 2001 and 2014, selected using healthcare administrative databases.

Participants: 12 676 patients who underwent bariatric surgery, age and sex matched with 38 028 obese and 126 760 non-obese controls.

Main outcome measures: Incidence and sites of fracture in patients who had undergone bariatric surgery compared with obese and non-obese controls. Fracture risk was also compared before and after surgery (index date) within each group and by type of surgery from 2006 to 2014. Multivariate conditional Poisson regression models were adjusted for fracture history, number of comorbidities, sociomaterial deprivation, and area of residence.

Results: Before surgery, patients undergoing bariatric surgery (9169 (72.3%) women; mean age 42 (SD 11) years) were more likely to fracture (1326; 10.5%) than were obese (3065; 8.1%) or non-obese (8329; 6.6%) controls. A mean of 4.4 years after surgery, bariatric patients were more susceptible to fracture (514; 4.1%) than were obese (1013; 2.7%) and non-obese (3008; 2.4%) controls. Postoperative adjusted fracture risk was higher in the bariatric group than in the obese (relative risk 1.38, 95% confidence interval 1.23 to 1.55) and non-obese (1.44, 1.29 to 1.59) groups. Before surgery, the risk of distal lower limb fracture was higher, upper limb fracture risk was lower, and risk of clinical spine, hip, femur, or pelvic fractures was similar in the bariatric and obese groups compared with the non-obese group. After surgery, risk of distal lower limb fracture decreased (relative risk 0.66, 0.56 to 0.78), whereas risk of upper limb (1.64, 1.40 to 1.93), clinical spine (1.78, 1.08 to 2.93), pelvic, hip, or femur (2.52, 1.78 to 3.59) fractures increased. The increase in risk of fracture reached significance only for biliopancreatic diversion.

Conclusions: Patients undergoing bariatric surgery were more likely to have fractures than were obese or non-obese controls, and this risk remained higher after surgery. Fracture risk was site specific, changing from a pattern associated with obesity to a pattern typical of osteoporosis after surgery. Only biliopancreatic diversion was clearly associated with fracture risk; however, results for Roux-en-Y gastric bypass and sleeve gastrectomy remain inconclusive. Fracture risk assessment and management should be part of bariatric care.

Conflict of interest statement

Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: no support from any organization for the submitted work; LB has received grants from Johnson and Johnson, Valen Tx, and GI Windows; LM has received honorariums (speakers’ fees) from Amgen, Abbvie, Eli Lilly, and Britsol Myers Squibb, as well as research equipment from Roche Diagnostics Canada; CG has been a member of advisory boards for Amgen and Eli Lilly; LB has been a member of advisory board for GI Windows; no other relationships or activities that could appear to have influenced the submitted work.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Figures

https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4964103/bin/gagc031922.f1_default.jpg
Fig 1 Hazard function representing non-adjusted fracture risk over time for each group
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4964103/bin/gagc031922.f2_default.jpg
Fig 2 Change in fracture risk after versus before surgery (or index date) within each group for all fractures and by fracture site. Data are presented as relative risk (95% CI) adjusted for duration of follow-up, age in middle of period, material and social deprivation, area of residence, history of fracture, and number of comorbidities in previous five years, using multivariate Poisson regression model for clustered data
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4964103/bin/gagc031922.f3_default.jpg
Fig 3 Non-adjusted fracture-free survival rate by site and by group
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4964103/bin/gagc031922.f4_default.jpg
Fig 4 Non-adjusted fracture-free survival rate (all fractures) by group and by type of bariatric procedure (for period between 2006 and 2014). Although fracture-free survival rate appears similar in adjustable gastric banding group to non-obese and obese groups, it is decreasing more rapidly in biliopancreatic diversion and Roux-en-Y gastric bypass groups. Follow-up time for sleeve gastrectomy is too short to draw conclusions

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