Reperfusion therapy for ST elevation acute myocardial infarction in Europe: description of the current situation in 30 countries

Petr Widimsky, William Wijns, Jean Fajadet, Mark de Belder, Jiri Knot, Lars Aaberge, George Andrikopoulos, Jose Antonio Baz, Amadeo Betriu, Marc Claeys, Nicholas Danchin, Slaveyko Djambazov, Paul Erne, Juha Hartikainen, Kurt Huber, Petr Kala, Milka Klinceva, Steen Dalby Kristensen, Peter Ludman, Josephina Mauri Ferre, Bela Merkely, Davor Milicic, Joao Morais, Marko Noc, Grzegorz Opolski, Miodrag Ostojic, Dragana Radovanovic, Stefano De Servi, Ulf Stenestrand, Martin Studencan, Marco Tubaro, Zorana Vasiljevic, Franz Weidinger, Adam Witkowski, Uwe Zeymer, European Association for Percutaneous Cardiovascular Interventions, Petr Widimsky, William Wijns, Jean Fajadet, Mark de Belder, Jiri Knot, Lars Aaberge, George Andrikopoulos, Jose Antonio Baz, Amadeo Betriu, Marc Claeys, Nicholas Danchin, Slaveyko Djambazov, Paul Erne, Juha Hartikainen, Kurt Huber, Petr Kala, Milka Klinceva, Steen Dalby Kristensen, Peter Ludman, Josephina Mauri Ferre, Bela Merkely, Davor Milicic, Joao Morais, Marko Noc, Grzegorz Opolski, Miodrag Ostojic, Dragana Radovanovic, Stefano De Servi, Ulf Stenestrand, Martin Studencan, Marco Tubaro, Zorana Vasiljevic, Franz Weidinger, Adam Witkowski, Uwe Zeymer, European Association for Percutaneous Cardiovascular Interventions

Abstract

Aims: Patient access to reperfusion therapy and the use of primary percutaneous coronary intervention (p-PCI) or thrombolysis (TL) varies considerably between European countries. The aim of this study was to obtain a realistic contemporary picture of how patients with ST elevation myocardial infarction (STEMI) are treated in different European countries.

Methods and results: The chairpersons of the national working groups/societies of interventional cardiology in European countries and selected experts known to be involved in the national registries joined the writing group upon invitation. Data were collected about the country and any existing national STEMI or PCI registries, about STEMI epidemiology, and treatment in each given country and about PCI and p-PCI centres and procedures in each country. Results from the national and/or regional registries in 30 countries were included in this analysis. The annual incidence of hospital admission for any acute myocardial infarction (AMI) varied between 90-312/100 thousand/year, the incidence of STEMI alone ranging from 44 to 142. Primary PCI was the dominant reperfusion strategy in 16 countries and TL in 8 countries. The use of a p-PCI strategy varied between 5 and 92% (of all STEMI patients) and the use of TL between 0 and 55%. Any reperfusion treatment (p-PCI or TL) was used in 37-93% of STEMI patients. Significantly less reperfusion therapy was used in those countries where TL was the dominant strategy. The number of p-PCI procedures per million per year varied among countries between 20 and 970. The mean population served by a single p-PCI centre varied between 0.3 and 7.4 million inhabitants. In those countries offering p-PCI services to the majority of their STEMI patients, this population varied between 0.3 and 1.1 million per centre. In-hospital mortality of all consecutive STEMI patients varied between 4.2 and 13.5%, for patients treated by TL between 3.5 and 14% and for patients treated by p-PCI between 2.7 and 8%. The time reported from symptom onset to the first medical contact (FMC) varied between 60 and 210 min, FMC-needle time for TL between 30 and 110 min, and FMC-balloon time for p-PCI between 60 and 177 min.

Conclusion: Most North, West, and Central European countries used p-PCI for the majority of their STEMI patients. The lack of organized p-PCI networks was associated with fewer patients overall receiving some form of reperfusion therapy.

Figures

Figure 1
Figure 1
Hospitalized STEMI treatment in Europe (data from national registries or surveys). 100%, all hospitalized STEMI patients in each given country; green colour, STEMI patients treated by primary PCI; red colour, STEMI patients treated by thrombolysis; black colour, STEMI patients not treated with any reperfusion. Countries abbreviations: CZ, Czech Republic; SLO, Slovenia; DE, Germany; CH, Switzerland; PL, Poland; HR, Croatia; SE, Sweden; HU, Hungary; BE, Belgium; IL, Israel; IT, Italy; FIN, Finland; AT, Austria; FR, France; SK, Slovakia; LAT, Latvia; UK, United Kingdom; BG, Bulgaria; PO, Portugal; SRB, Serbia; GR, Greece; TR, Turkey; RO, Romania.
Figure 2
Figure 2
Primary PCIs per year per million inhabitants in European countries. Grey colour, no data available; blue colour, countries participating in this study.
Figure 3
Figure 3
Correlation between the annual number of PCI procedures per million population and the gross domestic product per capita in European countries. (A) All PCI procedures. (B) Primary PCI procedures.
Figure 4
Figure 4
Time delays in patients treated by thrombolysis: ‘symptom onset—first medical contact’ and ‘first medical contact—start of thrombolysis’ time.
Figure 5
Figure 5
Time delays in patients treated by p-PCI: ‘symptom onset—first medical contact’ and ‘first medical contact—balloon’ time.
Figure 6
Figure 6
Percentage of STEMI patients arriving to the first hospital via EMS services. In the UK, Norway, Switzerland, and Sweden, physicians are only in ambulance helicopters, paramedics are in ambulance cars. In all other countries, physicians are in most or all EMS ambulances (cars and helicopters).

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