Maximizing number of doses drawn from multi-dose COVID-19 vaccines by minimizing dead-volume

Brendan Le Daré, Astrid Bacle, Roxane Lhermitte, François Lesourd, Yves Lurton, Brendan Le Daré, Astrid Bacle, Roxane Lhermitte, François Lesourd, Yves Lurton

No abstract available

Keywords: SARS-COV-2; Vaccine; dead-volume; extractable dose; medical device.

Figures

Figure 1

(a) Dead-volumes (μl) of different syringe—needle combinations measured according to standard method NF-EN ISO 7886-1. (b) Actual volume administered by different syringes at 0.3-ml graduation. (c) Number of extractable dose from Pfizer–BioNTech COVID-19 vaccine vials according to different syringe–needle combinations. The data are quoted as the mean ± standard error of mean from at least 5 (a), 50 (b) or 3 (c) independent and blinded measurements. The differences with the theoretical value (0.3 ml) were probed using t-test. ****P < 0.0001; ***P < 0.001; *P < 0.05: volume of one syringe compared with the theoretical volume withdrawn (0.3 ml)