Adherence to nutritional recommendations and subsequent cognitive performance: findings from the prospective Supplementation with Antioxidant Vitamins and Minerals 2 (SU.VI.MAX 2) study
Emmanuelle Kesse-Guyot, Hélène Amieva, Katia Castetbon, Adina Henegar, Monique Ferry, Claude Jeandel, Serge Hercberg, Pilar Galan, SU.VI.MAX 2 Research Group, Luc Vogt, Michèle E Escande, Jean-Marie Sérot, Emmanuel Vasseur, Matthieu Debray, Chantal Hussonnois, Martine Iehl-Robert, Myriam le Sommer, Thierry Boge, Josiane Rajaonarivo, Jean Jouseau, Monique Frison, Armelle Gentric, Fabienne Leenaert, Bernard Bascou, Jean-Paul Lemaire, Nathalie Baptiste, Marie-France Maugourd, Anne Gibelain, Roland Lopitaux, Jacques Hild, Henri Nachar, Géraldine Soulié, Francine Clémenti, Patrick Friocourt, Alain Sagnier, Philippe Schiano, Andréa Collet, Dominique Richard, Françoise Zandi, Pascal Couturier, Agathe Raynaud-Simon, Pierre Lermite, Michel Alix, Emmanuel Alix, François Puisieux, Cédric Gaxatte, Thierry Dantoine, Pierre Livet, Gilles Albrand, Pierre Haond, Pascal Ménecier, François Pinoche, Sylvie Guillaume, Marc Heim, André Wang, Claude Jeandel, Yves Passadori, Athanase Benetos, Catherine Couturier, Gilles Berrut, Sylvie Sacher-Huvelin, Henri Patouraux, Patrice Brocker, Olivier Guérin, Denise Strubel, Florence Dupriez, Jean-Bernard Gauvain, Yves Wolmark, Olivier Hanon, Bernard Bernard Cassou, Philippe Déjardin, François de la Fournière, Frédéric Wone, Claudine Buj-Hardy, Marc Paccalin, Bertrand Placines, Jean-Luc Novella, Pierre Jouanny, Florence Martin, Philippe Chassagne, Isabelle Landrin, Chantal Girtanner, Régis Gonthier, Claudie Troadec, Christophe Dourthe, Eric Bonnin, Jean-Paul Marot, Sylvie Rossignol, Georges Sebbane, Pierre-Yves Cornu, Jean-Jacques Monsuez, Isabelle Périllat, Robert Ratiney, Georges Kaltenbach, Yves Rolland, Thierry Constans, Gisèle Coz, Monique Ferry, Jean Pierre Aquino, Odile Cézard, Emmanuelle Kesse-Guyot, Hélène Amieva, Katia Castetbon, Adina Henegar, Monique Ferry, Claude Jeandel, Serge Hercberg, Pilar Galan, SU.VI.MAX 2 Research Group, Luc Vogt, Michèle E Escande, Jean-Marie Sérot, Emmanuel Vasseur, Matthieu Debray, Chantal Hussonnois, Martine Iehl-Robert, Myriam le Sommer, Thierry Boge, Josiane Rajaonarivo, Jean Jouseau, Monique Frison, Armelle Gentric, Fabienne Leenaert, Bernard Bascou, Jean-Paul Lemaire, Nathalie Baptiste, Marie-France Maugourd, Anne Gibelain, Roland Lopitaux, Jacques Hild, Henri Nachar, Géraldine Soulié, Francine Clémenti, Patrick Friocourt, Alain Sagnier, Philippe Schiano, Andréa Collet, Dominique Richard, Françoise Zandi, Pascal Couturier, Agathe Raynaud-Simon, Pierre Lermite, Michel Alix, Emmanuel Alix, François Puisieux, Cédric Gaxatte, Thierry Dantoine, Pierre Livet, Gilles Albrand, Pierre Haond, Pascal Ménecier, François Pinoche, Sylvie Guillaume, Marc Heim, André Wang, Claude Jeandel, Yves Passadori, Athanase Benetos, Catherine Couturier, Gilles Berrut, Sylvie Sacher-Huvelin, Henri Patouraux, Patrice Brocker, Olivier Guérin, Denise Strubel, Florence Dupriez, Jean-Bernard Gauvain, Yves Wolmark, Olivier Hanon, Bernard Bernard Cassou, Philippe Déjardin, François de la Fournière, Frédéric Wone, Claudine Buj-Hardy, Marc Paccalin, Bertrand Placines, Jean-Luc Novella, Pierre Jouanny, Florence Martin, Philippe Chassagne, Isabelle Landrin, Chantal Girtanner, Régis Gonthier, Claudie Troadec, Christophe Dourthe, Eric Bonnin, Jean-Paul Marot, Sylvie Rossignol, Georges Sebbane, Pierre-Yves Cornu, Jean-Jacques Monsuez, Isabelle Périllat, Robert Ratiney, Georges Kaltenbach, Yves Rolland, Thierry Constans, Gisèle Coz, Monique Ferry, Jean Pierre Aquino, Odile Cézard
Abstract
Background: Few studies have investigated the long-term effect of overall nutritional recommendations on cognition.
Objective: In a French cohort of middle-aged adults, we evaluated the association between the French National Nutrition and Health Program (Program National Nutrition Santé) Guideline Score (PNNS-GS) assessed at baseline and cognitive performance evaluated 13 y later.
Design: The PNNS-GS was estimated at baseline (1994-1996) (maximum score: 15 points) in 2135 subjects in the SU.VI.MAX (Supplementation with Antioxidant Vitamins and Minerals) study. We assessed cognitive performance of subjects in 2007-2009 via a battery of 4 neuropsychologic tests that included phonemic and semantic fluency, the RI-48 (rappel indicé-48 item) cued-recall test, the trail-making test, and forward and backward digit spans. A principal components analysis was performed to account for correlations in test scores. Multivariate linear regression models or analyses of covariance were also performed.
Results: In a multivariate model, we observed a positive association between the PNNS-GS and the cued-recall test and semantic and phonemic fluency tasks, whereas no association was observed with digit spans. The principal components analysis revealed 2 factors interpreted as reflecting verbal memory and executive functioning. Better adherence to nutritional recommendations was significantly associated with the verbal memory factor (β = 0.41; 95% CI: 0.17, 0.64), whereas no association was shown with the executive functioning factor. Removing specific components from the PNNS-GS did not modify the findings.
Conclusion: This study suggests that strong compliance with nutritional recommendations in midlife is associated in elderly individuals with better verbal memory, which is a cognitive domain that is particularly vulnerable to pathologic aging and Alzheimer disease. This trial was registered at clinicaltrials.gov as NCT00272428.
Source: PubMed