Alexithymia Predicts Attrition and Outcome in Weight-Loss Obesity Treatment

Mario Altamura, Piero Porcelli, Beth Fairfield, Stefania Malerba, Raffaella Carnevale, Angela Balzotti, Giuseppe Rossi, Gianluigi Vendemiale, Antonello Bellomo, Mario Altamura, Piero Porcelli, Beth Fairfield, Stefania Malerba, Raffaella Carnevale, Angela Balzotti, Giuseppe Rossi, Gianluigi Vendemiale, Antonello Bellomo

Abstract

Obesity is a psychosomatic condition characterized by a complex interaction of biological and psychological factors and a large body of research has aimed to identify variables limiting efficacy and determining high attrition rates in weight loss programs. In this study, we used the Diagnostic Criteria for Psychosomatic Research (DCPR), designed to broaden the clinician's perspective on patients' problems by providing additional clinical information not found in the more traditional psychiatric classification, to predict psychosomatic variables that may limit efficacy and determine attrition in clinical interventions with people with obesity. We evaluated 82 consecutive participants with obesity at baseline for psychopathology, psychosomatic correlates, psychological distress, and eating-related symptoms before entering a weight loss program. Regression models were used to assess attrition and outcome at a 6-month follow-up and per-protocol and intention-to-treat analyses were performed. DPCR alexithymia significantly predicted attrition (OR = 6.9), and unsuccessful weight-loss (OR = 11.3). These findings suggest that the identification of psychosomatic factors, in addition to psychological and psychopathological factors, may predict adherence to weight-loss programs.

Keywords: alexithymia; clinical intervention; diagnostic criteria for psychosomatic research; dropout; obesity; predictive factors.

References

    1. Altamura M., Porcelli P., Balzotti A., Massaro C. R. M., Bellomo A. (2015a). Influence of DCPR syndromes in the psychosocial functioning of patients with major depressive and bipolar disorders. Psychother. Psychosom. 84 387–388. 10.1159/000437148
    1. Altamura M., Rossi G., Aquilano P., De Fazio P., Segura-Garcia C., Rossetti M., et al. (2015b). Disordered eating behavior and mental health correlates among treatment seeking obese women. Clin. Ter. 166:e330-4. 10.7417/T.2015.1888
    1. Bellomo A., Altamura M., Ventriglio A., Rella A., Quartesan R., Elisei S. (2007). “Psychological factors affecting medical conditions in consultation-liaison psychiatry,” in Psychological Factors Affecting Medical Conditions. A New Classification for DSM-V. Adv Psychosom Med Vol. 28 eds Porcelli P., Sonino N. (Basel: Karger; ) 127–140.
    1. Berrocal C., Pennato T., Bernini O. (2009). Relating coping, fear of uncertainty, and alexithymia with psychological distress: the mediator role of experiential avoidance. J. Cognit. Behav. Psychother. 9 149–159.
    1. Colombo O., Ferretti V. V., Ferraris C., Trentani C., Vinai P., Villani S., et al. (2014). Is drop-out obesity treatment a predictable and preventable event? Nutr. J. 13:13. 10.1186/1475-2891-13-13
    1. Cuntz U., Leibbrand R., Ehrig C., Shaw R., Fichter M. M. (2001). Predictors of post- treatment weight reduction after in-patient behavioral therapy. Int. J. Relat. Metab. Disord. 25 S99–S101.
    1. Da Ros A., Vinai P., Gentile N., Forza G., Cardetti S. (2011). Evaluation of alexithymia and depression in severe obese patients not affected by eating disorders. Eat. Weight Disord. 16 e24–e29. 10.1007/BF03327517
    1. Dalle Grave R., Calugi S., Corica F., Di Domizio S., Marchesini G. (2009). Psychological variables associated with weight loss in obese patients seeking treatment at medical centers. J. Am. Diet. Assoc. 109 2010–2016. 10.1016/j.jada.2009.09.011
    1. Dalle Grave R., Calugi S., El Ghoch M. (2018). Are personality characteristics as measured by the Temperament and Character Inventory (TCI) associated with obesity treatment outcomes? A systematic review. Curr. Obes. Rep. 7 27–36. 10.1007/s13679-018-0294-y
    1. Dalle Grave R., Calugi S., Molinari E., Petroni M. L., Bondi M., Compare A., et al. (2005). Weight loss expectations in obese patients and treatment attrition: an observational multicenter study. Obes. Res. 13 1961–1969. 10.1038/oby.2005.241
    1. Dalle Grave R. D., Suppini A., Calugi S., Marchesini G. (2006). Factors associated with attrition in weight loss programs. Int. J. Behav. Consult. Ther. 2 341–353. 10.1037/h0100788
    1. De Chouly De Lenclave M. B., Florequin C., Bailly D. (2001). [Obesity, alexithymia, psychopathology and binge eating: a comparative study of 40 obese patients and 32 controls]. Encephale 27 343–350.
    1. De Panfilis C., Cero S., Dall’Aglio E., Salvatore P., Torre M., Maggini C. (2007). Psychopathological predictors of compliance and outcome in weight-loss obesity treatment. Acta Biomed. 78 22–28.
    1. De Panfilis C., Torre M., Cero S., Salvatore P., Dall’Aglio E., Marchesi C., et al. (2008). Personality and attrition from behavioral weight-loss treatment for obesity. Gen. Hosp. Psychiatry 30 515–520. 10.1016/j.genhosppsych.2008.06.003
    1. Derogatis L. R., Cleary P. A. (1977). Confirmation of the dimensional structure of the scl-90: a study in construct validation. J. Clin. Psychol. 33 981–989.
    1. Elfhag K., Rössner S. (2010). Initial weight loss is the best predictor for success in obesity treatment and sociodemographic liabilities increase risk for drop-out. Patient Educ. Couns. 79 361–366. 10.1016/j.pec.2010.02.006
    1. Fabricatore A. N., Wadden T. A., Moore R. H., Butryn M. L., Heymsfield S. B., Nguyen A. M. (2009). Predictors of attrition and weight loss success: results from a randomized controlled trial. Behav. Res. Ther. 47 685–691. 10.1016/j.brat.2009.05.004
    1. Farley R. L., Wade T. D., Birchmore L. (2003). Factors influencing attendance at cardiac rehabilitation among coronary heart disease patients. Eur. J. Cardiovasc. Nurs. 2 205–212. 10.1016/S1474-5151(03)00060-4
    1. Fassino S., Daga G., Pierò A., Delsedime N. (2007). “Psychological factors affecting eating disorders. in psychological factors affecting medical conditions,” in A New Classification for DSM-445 V. Adv Psychosom Med Vol. 28 eds Porcelli P., Sonino N. (Basel: Karger; ) 141–168.
    1. Fassino S., Leombruni P., Pierò A., Abbate-Daga G., Rovera G. G. (2003). Mood, eating attitudes, and anger in obese women with and without Binge Eating Disorder. J. Psychosom. Res. 54 559–566. 10.1016/S0022-3999(02)00462-2
    1. Fassino S., Pierò A., Gramaglia C., Abbate-Daga G. (2004). Clinical, psychopathological and personality correlates of interoceptive awareness in anorexia nervosa, bulimia nervosa and obesity. Psychopathology 37 168–174. 10.1159/000079420
    1. Fava G. A., Freyberger H. J., Bech P., Christodoulou G., Sensky T., Theorell T., et al. (1995). Diagnostic criteria for use in psychosomatic research. Psychother. Psychosom. 63 1–8. 10.1159/000288931
    1. Fernandes J., Ferreira-Santos F., Miller K., Torres S. (2018). Emotional processing in obesity: a systematic review and exploratory meta-analysis. Obes. Rev. 19 111–120. 10.1111/obr.12607
    1. Gariepy G., Nitka D., Schmitz N. (2010). The association between obesity and anxiety disorders in the population: a systematic review and meta-analysis. Int. J. Obes. 34 407–419. 10.1038/ijo.2009.252
    1. Garner D. M., Bohr Y., Garfinkel P. E. (1982). The eating attitudes test: psychometric features and clinical correlates. Psychol. Med. 12 871–878. 10.1017/S0033291700049163
    1. Giel K. E., Teufel M., Junne F., Zipfel S., Schag K. (2017). Food-related impulsivity in obesity and binge eating disorder—a systematic update of the evidence. Nutrients 9:E1170. 10.3390/nu9111170
    1. Grabe H. J., Spitzer C., Freyberger H. J. (2001). Alexithymia and the temperament and character model of personality. Psychother. Psychosom. 70 261–267. 10.1159/000056264
    1. Grossi E., Dalle Grave R., Mannucci E., Molinari E., Compare A., Cuzzolaro M., et al. (2006). Complexity of attrition in the treatment of obesity: clues from a structured telephone interview. Int. J. Obes. 30 1132–1137. 10.1038/sj.ijo.0803244
    1. Guidi J., Rafanelli C., Roncuzzi R., Sirri L., Fava G. A. (2013). Assessing psychological factors affecting medical conditions: comparison between different proposals. Gen. Hosp. Psychiatry 35 141–146. 10.1016/j.genhosppsych.2012.09.007
    1. Hays N. P., Roberts S. B. (2008). Aspects of eating behaviors disinhibition and restraint are related to weight gain and BMI in women. Obesity 16 52–58. 10.1038/oby.2007.12
    1. Inelmen E. M., Toffanello E. D., Enzi G., Gasparini G., Miotto F., Sergi G., et al. (2005). Predictors of drop-out in overweight and obese outpatients. Int. J. Obes. 29 122–128. 10.1038/sj.ijo.0802846
    1. Jiandani D., Wharton S., Rotondi M. A., Ardern C. I., Kuk J. L. (2016). Predictors of early attrition and successful weight loss in patients attending an obesity management program. BMC Obes. 3:14. 10.1186/S40608-016-0098-0
    1. Karasu S. R. (2012). Of mind and matter: psychological dimensions in obesity. Am. J. Psychother. 66 111–128.
    1. Lakerveld J., Bot S. D., Chinapaw M. J., van Tulder M. W., Kostense P. J., Dekker J. M., et al. (2013). Motivational interviewing and problem solving treatment to reduce type 2 diabetes and cardiovascular disease risk in real life: a randomized controlled trial. Int. J. Behav. Nutr. Phys. Acta 10:47. 10.1186/1479-5868-10-47
    1. Lazzeretti L., Rotella F., Pala L., Rotella C. M. (2015). Assessment of psychological predictors of weight loss: How and what for? World J. Psychiatry 5 56–67. 10.5498/wjp.v5.i1.56
    1. Lejeune M. P., van Aggel-Leijssen D. P. C., van Baak M. A., Westerterp-Plantenga M. S. (2003). Effects of dietary restraint vs exercise during weight maintenance in obese men. Eur. J. Clin. Nutr. 57 1338–1344. 10.1038/sj.ejcn.1601697
    1. Leombruni P., Rocca G., Fassino S., Gastaldi F., Nicotra B., Siccardi S., et al. (2014). An exploratory study to subtype obese binge eaters by personality traits. Psychother. Psychosom. 83 114–118. 10.1159/000356810
    1. Lumley M. A., Neely L. C., Burger A. J. (2007). The assessment of alexithymia in medical settings: implications for understanding and treating health problems. J. Pers. Assess. 89 230–246. 10.1080/00223890701629698
    1. Michelini I., Falchi A. G., Muggia C., Grecchi I., Montagna E., De Silvestri A., et al. (2014). Early dropout predictive factors in obesity treatment. Nutr. Res. Pract. 8 94–102. 10.4162/nrp.2014.8.1.94
    1. Minniti A., Bissoli L., Di Francesco V., Olivieri M., Mandragona R., Mazzali G., et al. (2004). The relationship between body image and quality of life in treatment-seeking overweight women. Eat. Weight Disord. 9 206–210. 10.1007/BF03325068
    1. Mobbs O., Crépin C., Thiéry C., Golay A., Van der Linden M. (2010). Obesity and the four facets of impulsivity. Patient Educ. Couns. 79 372–377. 10.1016/j.pec.2010.03.003
    1. Moriguchi Y., Komaki G. (2013). Neuroimaging studies of alexithymia: physical, affective, and social perspectives. Biopsychosoc. Med. 7:8. 10.1186/1751-0759-7-8
    1. Moroshko I., Brennan L., O’Brien P. (2011). Predictors of dropout in weight loss interventions: a systematic review of the literature. Obes. Rev. 12 912–934. 10.1111/j.1467-789X.2011.00915.x
    1. Munro I. A., Bore M. R., Munro D., Garg M. L. (2011). Using personality as a predictor of diet induced weight loss and weight management. Int. J. Behav. Nutr. Phys. Act. 8:129. 10.1186/1479-5868-8-129
    1. Naper J., Manetto L., Wiren D. (2017). A project to improve the quality of care for overweight and obese patients in a Nelson general practice. J. Prim. Health Care 9 321–327. 10.1071/HC17009
    1. Orbitello B., Ciano R., Corsaro M., Rocco P. L., Taboga C., Tonutti L., et al. (2006). The EAT-26 as screening instrument for clinical nutrition unit attenders. Int. J. Obes. 30 977–981. 10.1038/sj.ijo.0803238
    1. Ortega F. B., Lavie C. J., Blair S. N. (2016). Obesity and cardiovascular disease. Circ. Res. 118 1725–1770. 10.1161/CIRCRESAHA.115.306883
    1. Pinaquy S., Chabrol H., Simon C., Louvet J. P., Barbe P. (2003). Emotional eating, alexithymia, and binge-eating disorder in obese women. Obes. Res. 11 195–201. 10.1038/oby.2003.31
    1. Pinna F., Sanna L., Carpiniello B. (2014). Alexithymia in eating disorders: therapeutic implications. Psychol. Res. Behav. Manag. 8 1–15. 10.2147/PRBM.S52656
    1. Porcelli P., Bagby R. M., Taylor G. J., De Carne M., Leandro G., Todarello O. (2003). Alexithymia as predictor of treatment outcome in patients with functional gastrointestinal disorders. Psychosom. Med. 65 911–918. 10.1097/01.PSY.0000089064.13681.3B
    1. Porcelli P., Guidi J. (2015). The clinical utility of the diagnostic criteria for psychosomatic research: a review of studies. Psychother. Psychosom. 4 265–272. 10.1159/000430788
    1. Porcelli P., Rafanelli C. (2010). Criteria for psychosomatic research (DCPR) in the medical setting. Curr. Psychiatry Rep. 12 246–254. 10.1007/s11920-010-0104-z
    1. Poston W. S., Foreyt J. P. (2000). Successful management of the obese patient. Am. Fam. Phys. 61 3615–3622.
    1. Reed D. (2014). Healthy eating for healthy nurses: nutrition basics to promote health for nurses and patients. Online J. Issues Nurs. 19:7.
    1. Sheehan D. V., Lecrubier Y., Sheehan K. H., Amorim P., Janavs J., Weiller E., et al. (1998). The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry. 59 22–33.
    1. Stone T. W., McPherson M., Gail Darlington L. (2018). Obesity and cancer: existing and new hypotheses for a causal connection. EBioMedicine 30 14–28. 10.1016/j.ebiom.2018.02.022
    1. Sullivan S., Cloninger C. R., Przybeck T. R., Klein S. (2007). Personality characteristics in obesity and relationship with successful weight loss. Int. J. Obes. 31 669–674. 10.1038/sj.ijo.0803464
    1. Sutin A. R., Ferrucci L., Zonderman A. B., Terracciano A. (2011). Personality and obesity across the adult life Span. J. Pers. Soc. Psychol. 101 579–592. 10.1037/a0024286
    1. Teixeira P. J., Going S. B., Houtkooper L. B., Cussler E. C., Martin C. J., Metcalfe L. L., et al. (2002). Weight loss readiness in middle-aged women: psychosocial predictors of success for behavioral weight reduction. J. Behav. Med. 25 499–523. 10.1023/A:1020687832448
    1. Teixeira P. J., Going S. B., Houtkooper L. B., Cussler E. C., Metcalfe L. L., Blew R. M., et al. (2004). Pretreatment predictors of attrition and successful weight management in women. Int. J. Obes. Relat. Metab. Disord. 28 1124–1133. 10.1038/sj.ijo.0802727
    1. Teixeira P. J., Going S. B., Sardinha L. B., Lohman T. G. (2005). A review of psychosocial pre-treatment predictors of weight control. Obes. Rev. 6 43–65. 10.1111/j.1467-789X.2005.00166.x
    1. Traverso A., Ravera G., Lagattolla V., Testa S., Adami G. F. (2000). Weight loss after dieting with behavioral modification for obesity: the predicting efficiency of some psychometric data. Eat. Weight Disord. 5 102–107. 10.1007/BF03327485
    1. Ural C., Belli H., Akbudak M., Solmaz A., Bektas Z. D., Celebi F. (2017). Relation of binge eating disorder with impulsiveness in obese individuals. World J. Psychiatry 7 114–120. 10.5498/wjp.v7.i2.114
    1. Van Hout G. C. M., Van Oudheusden I., Van Heck G. L. (2004). Psychological profile of the morbidly obese. Obes. Surg. 14 579–588. 10.1381/096089204323093336
    1. van Sluijs E. M. F., van Poppel M. N. M., van Mechelen W. (2004). Stage-based lifestyle interventions in primary care: Are they effective? Am. J. Prev. Med. 26 330–343. 10.1016/j.amepre.2003.12.010
    1. VanderBroek-Stice L., Stojek M. K., Beach S. R. H., vanDellen M. R., MacKillop J. (2017). Multidimensional assessment of impulsivity in relation to obesity and food addiction. Appetite 112 59–68. 10.1016/j.appet.2017.01.009
    1. Vanheule S., Meganck R., Desmet M. (2011). Alexithymia, social detachment and cognitive processing. Psychiatry Res. 112 59–68. 10.1016/j.psychres.2010.06.032
    1. Venditti F., Cosci F., Bernini O., Berrocal C. (2013). Criterion validity of the diagnostic criteria for psychosomatic research in patients with morbid obesity. Psychother. Psychosom. 82 411–412. 10.1159/000353601
    1. Ware J. H. (2003). Interpreting incomplete data in studies of diet and weight loss. N. Engl. J. Med. 348 2136–2137. 10.1056/NEJMe030054
    1. Westwood H., Kerr-Gaffney J., Stahl D., Tchanturia K. (2017). Alexithymia in eating disorders: systematic review and meta-analyses of studies using the Toronto Alexithymia Scale. J. Psychosom. Res. 99 66–81. 10.1016/j.jpsychores.2017.06.007
    1. Wheeler K., Greiner P., Boulton M. (2005). Exploring alexithymia, depression, and binge eating in self-reported eating disorders in women. Perspect. Psychiatr. Care 41 114–123. 10.1111/j.1744-6163.2005.00022.x
    1. Wing R. R., Hill J. O. (2001). Successful weight loss maintenance. Annu. Rev. Nutr. 21 323–341. 10.1146/annurev.nutr.21.1.323

Source: PubMed

3
Abonnere