Breast cancer risk and protracted low-to-moderate dose occupational radiation exposure in the US Radiologic Technologists Cohort, 1983-2008

D L Preston, C M Kitahara, D M Freedman, A J Sigurdson, S L Simon, M P Little, E K Cahoon, P Rajaraman, J S Miller, B H Alexander, M M Doody, M S Linet, D L Preston, C M Kitahara, D M Freedman, A J Sigurdson, S L Simon, M P Little, E K Cahoon, P Rajaraman, J S Miller, B H Alexander, M M Doody, M S Linet

Abstract

Background: Although high-dose ionising radiation is associated with increased breast cancer risks, the association with protracted low-dose-rate exposures remains unclear. The US Radiologic Technologist study provides an opportunity to examine the association between low-to-moderate dose radiation and breast cancer incidence and mortality.

Methods: One thousand nine hundred and twenty-two self-reported first primary cancers were diagnosed during 1983-2005 among 66 915 female technologists, and 586 breast cancer deaths occurred during 1983-2008 among 83 538 female cohort members. Occupational breast dose estimates were based on work histories, historical data, and, after the mid-1970s, individual film badge measurements. Excess relative risks were estimated using Poisson regression with birth cohort stratification and adjustment for menopause, reproductive history, and other risk factors.

Results: Higher doses were associated with increased breast cancer incidence, with an excess relative risk at 100 mGy of 0.07 (95% confidence interval (CI): -0.005 to 0.19). Associations were strongest for technologists born before 1930 (excess relative risk at 100 mGy=0.16; 95% CI: 0.03-0.39) with similar patterns for mortality among technologists born before 1930.

Conclusions: Occupational radiation to the breast was positively associated with breast cancer risk. The risk was more pronounced for women born before 1930 who began working before 1950 when mean annual doses (37 mGy) were considerably higher than in later years (1.3 mGy). However, because of the uncertainties and possible systematic errors in the occupational dose estimates before 1960, these findings should be treated with caution.

Figures

Figure 1
Figure 1
Birth cohort-specific fitted breast cancer incidence (A) and mortality (B) dose–response curves (solid lines) with categorical excess relative risk estimates (ERRs) (closed circles) and 95% confidence limits. The dashed lines are the fitted linear dose–response curves assuming that the ERR is the same in all birth cohorts.

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