Chronic lung disease in children and adolescents with HIV: a case-control study

Grace McHugh, Andrea M Rehman, Victoria Simms, Carmen Gonzalez-Martinez, Tsitsi Bandason, Ethel Dauya, Brewster Moyo, Hilda Mujuru, Jamie Rylance, Evgeniya Sovershaeva, Helen A Weiss, Katharina Kranzer, Jon Odland, Rashida A Ferrand, BREATHE Clinical Trial Team, Elizabeth L Corbett, Trond Flaegstad, Tore J Gutteberg, Jorunn Pauline Cavanagh, Edith Majonga, Felix Dube, Slee Mhbele, Louis-Marie Yindom, Sarah Rowland-Jones, Mark Nicol, Grace McHugh, Andrea M Rehman, Victoria Simms, Carmen Gonzalez-Martinez, Tsitsi Bandason, Ethel Dauya, Brewster Moyo, Hilda Mujuru, Jamie Rylance, Evgeniya Sovershaeva, Helen A Weiss, Katharina Kranzer, Jon Odland, Rashida A Ferrand, BREATHE Clinical Trial Team, Elizabeth L Corbett, Trond Flaegstad, Tore J Gutteberg, Jorunn Pauline Cavanagh, Edith Majonga, Felix Dube, Slee Mhbele, Louis-Marie Yindom, Sarah Rowland-Jones, Mark Nicol

Abstract

Objective: To describe the features of HIV-associated chronic lung disease (CLD) in older children and adolescents living with HIV and to examine the clinical factors associated with CLD. This is a post hoc analysis of baseline data from the BREATHE clinical trial (ClinicalTrials.gov, NCT02426112).

Methods: Children and adolescents aged 6-19 years were screened for CLD (defined as a FEV1 z-score <-1 with no reversibility post-bronchodilation with salbutamol) at two HIV clinics in Harare, Zimbabwe, and Blantyre, Malawi. Eligible participants with CLD (cases) were enrolled, together with a control group without CLD [frequency-matched by age group and duration on antiretroviral therapy (ART)] in a 4:1 allocation ratio. A clinical history and examination were undertaken. The association between CLD and a priori-defined demographic and clinical covariates was investigated using multivariable logistic regression.

Results: Of the 1585 participants screened, 419 (32%) had a FEV1 z-score <-1, of whom 347 were enrolled as cases [median age 15.3 years (IQR 12.7-17.7); 48.9% female] and 74 with FEV1 z-score >0 as controls [median age 15.6 years (IQR 12.1-18.2); 62.2% female]. Among cases, current respiratory symptoms including cough and shortness of breath were reported infrequently (9.3% and 1.8%, respectively). However, 152 (43.8%) of cases had a respiratory rate above the 90th centile for their age. Wasting and taking second-line ART were independently associated with CLD.

Conclusions: The presence of CLD indicates the need to address additional treatment support for youth living with HIV, alongside ART provision, to ensure a healthier adulthood.

Keywords: Africa; Afrique; HIV; VIH; adolescents; chronic lung disease; maladie pulmonaire chronique.

© 2020 John Wiley & Sons Ltd.

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