Promising therapeutic role of miR-27b in tumor
Li Ding, Jie Ni, Fan Yang, Lingli Huang, Heng Deng, Yang Wu, Xuansheng Ding, Jinhai Tang, Li Ding, Jie Ni, Fan Yang, Lingli Huang, Heng Deng, Yang Wu, Xuansheng Ding, Jinhai Tang
Abstract
MicroRNAs are small nonprotein-encoding RNAs ranging from 18 to 25 nucleotides in size and regulate multiple biological pathways via directly targeting a variety of associated genes in cancers. MicroRNA-27b is a highly conserved MicroRNA throughout vertebrates and there are two homologs (hsa-miR-27a and hsa-miR-27b) in humans. MicroRNA-27b is an intragenic microRNA located on chromosome 9q22.1 within the C9orf3 gene, clustering with miR-23b and miR-24-1 in human. As a frequently dysregulated microRNA in human cancers, microRNA-27b could function as a tumor suppressor or an oncogenic microRNA. More and more studies indicate that microRNA-27b is involved in affecting various biological processes, such as angiogenesis, proliferation, metastasis, and drug resistance, and thus may act as a promising therapeutic target in human cancers. In this review, we discuss the role of microRNA-27b in detail and offer novel insights into molecular targeting therapy for cancers.
Keywords: MicroRNA; biomarker; cancer; microRNA-27b; therapy.
Source: PubMed