Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients
Vincent Dupont, Lukshe Kanagaratnam, Antoine Goury, Gaël Poitevin, Mathieu Bard, Gauthier Julien, Michel Bonnivard, Vanessa Champenois, Violaine Noel, Bruno Mourvillier, Philippe Nguyen, Vincent Dupont, Lukshe Kanagaratnam, Antoine Goury, Gaël Poitevin, Mathieu Bard, Gauthier Julien, Michel Bonnivard, Vanessa Champenois, Violaine Noel, Bruno Mourvillier, Philippe Nguyen
Abstract
Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration: NCT04394195.
Keywords: COVID-19; critical care; endothelial dysfunction; sFlt-1.
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Source: PubMed