The onset of nausea and vomiting of pregnancy: a prospective cohort study

Roger Gadsby, Diana Ivanova, Emma Trevelyan, Jane L Hutton, Sarah Johnson, Roger Gadsby, Diana Ivanova, Emma Trevelyan, Jane L Hutton, Sarah Johnson

Abstract

Background: Nausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period METHODS: Prospective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last menstrual period (LMP) or luteinising hormone surge until onset of nausea or vomiting.

Results: Almost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symptoms within 11 to 20 days of ovulation.

Conclusions: Onset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface.

Trial registration: NCT01577147 . Date of registration 13 April 2012.

Keywords: Last menstrual period; Luteinising hormone (LH) surge; Nausea; Onset; Pregnancy; Vomiting.

Conflict of interest statement

None: RG, ET, DI, JLH. SJ is an employee of SPD Development Company Limited, a fully owned subsidiary of SPD Development Company GmbH, the manufacturer of Clearblue pregnancy and fertility diagnostics.

Figures

Fig. 1
Fig. 1
Days from LMP and from Ovulation day to hCG >1mlU/ml (256 women)
Fig. 2
Fig. 2
Distribution of onset of symptoms from LMP and from Ovulation (214 women)
Fig. 3
Fig. 3
Onset of symptoms from ovulation: association with age and body mass index (BMI), 214 women

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