Perspective: Creating the Evidence Base for Nutritional Support in Childhood Cancer in Low- and Middle-Income Countries: Priorities for Body Composition Research

Alexia J Murphy-Alford, Maya Prasad, Jeremy Slone, Katja Stein, Terezie T Mosby, Alexia J Murphy-Alford, Maya Prasad, Jeremy Slone, Katja Stein, Terezie T Mosby

Abstract

There is a striking disparity in survival rates for children in low- and middle-income countries (LMICs) compared with high-income countries (HICs). Many of the contributing factors are preventable, including the comorbidity of malnutrition. There are emerging data that malnutrition, as reflected in body composition changes, impacts survival of cancer. However, not enough priority is given to nutrition management of children with cancer, particularly in LMICs. The primary purpose of this article is to review the current knowledge on childhood cancer and body composition in LMICs and identify priorities for future research into the interlinking associations between cancer, body composition, and clinical outcomes for childhood cancer patients. Evidence will ensure feasible and effective nutrition management is prioritized in childhood cancer centers in LMICs and contribute to improving outcomes for children with cancer.

Keywords: body composition; childhood cancer; clinical outcomes; low- and middle-income countries; malnutrition; nutrition support.

Copyright © American Society for Nutrition 2019.

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