Effects of exercise training on patients with lung cancer who underwent lung resection: a meta-analysis

Jie Li, Nan-Nan Guo, Hai-Rong Jin, Hua Yu, Peng Wang, Guo-Gang Xu, Jie Li, Nan-Nan Guo, Hai-Rong Jin, Hua Yu, Peng Wang, Guo-Gang Xu

Abstract

Background: The efficacy of exercise training in patients with lung cancer after lung resection has not been well established yet. Therefore, we performed a meta-analysis to investigate the efficiency of exercise training in patients with lung cancer after lung resection.

Methods: Several databases were searched for eligible randomised controlled trials (RCTs). The primary outcome was quality of life, and the secondary outcomes included 6-min walk distance (6MWD), forced expiratory volume in 1 s (FEV1) and postoperative complications (POCs). Weighted mean differences (WMDs) and relative risks (RRs) with 95% confidence intervals (CIs) were calculated by random-effects model.

Results: Six RCTs involving 438 patients were enrolled in this meta-analysis. The pooled WMDs of the scores were 2.41 (95% CI = -5.20 to 10.02; P = 0.54) and -0.46 (95% CI = -20.52 to 19.61; P = 0.96) for the physical and mental components of the 36-item short-form scale, respectively. The pooled WMDs were 23.50 m (95% CI = -22.04 to 69.03; P = 0.31) for 6MWD and 0.03 L (95% CI = -0.19 to 0.26; P = 0.76) for FEV1. Finally, the pooled RRs were 0.79 (95% CI = 0.41 to 1.53; P = 0.49) for POCs.

Conclusions: Insufficient evidence is available to support the efficacy of exercise training in patients with lung cancer after lung resection. Further studies must confirm our findings and investigate the long-term effects of exercise training on patients with lung cancer following lung resection.

Keywords: Exercise; Lung cancer; Meta-analysis; Quality of life.

Conflict of interest statement

Ethics approval and consent to participate

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Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Search strategy and flow chart (randomised controlled trials; RCTs)
Fig. 2
Fig. 2
Risk-of-bias assessment: risk-of-bias graph (a) and risk-of-bias summary (b)
Fig. 3
Fig. 3
Forest plot of QoL, including the physical and mental components of the SF-36 scale
Fig. 4
Fig. 4
Forest plot of secondary outcomes including 6MWD (a), FEV1 (b) and POCs (c)

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