Daily energy expenditure through the human life course

Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Teresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia Loechl, Amy H Luke, Jennifer Rood, Dale A Schoeller, Klaas R Westerterp, William W Wong, John R Speakman, IAEA DLW Database Consortium, Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Teresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia Loechl, Amy H Luke, Jennifer Rood, Dale A Schoeller, Klaas R Westerterp, William W Wong, John R Speakman, IAEA DLW Database Consortium

Abstract

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Conflict of interest statement

Conflict of interest

The authors have no conflicts of interest to declare.

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Figures

Figure 1.
Figure 1.
A. Total expenditure (TEE) increases with fat free mass in a power-law manner, but age groups cluster about the trend line differently. B. Total expenditure rises in childhood, is stable through adulthood, and declines in older adults. Means±sd for age-sex cohorts are shown. C. Age-sex cohort means show a distinct progression of total expenditure and fat free mass over the life course. D. Neonate, juveniles, and adults exhibit distinct relationships between fat free mass and expenditure. The dashed line, extrapolated from the regression for adults, approximates the regression used to calculate adjusted total expenditure.
Figure 2.
Figure 2.
Fat free mass- and fat mass-adjusted expenditures over the life course. Individual subjects and age-sex cohort mean ± SD are shown. For both total (Adj. TEE) (A) and basal (Adj. BEE) expenditure (B), adjusted expenditures begin near adult levels (~100%) but quickly climb to ~150% in the first year. Adjusted expenditures decline to adult levels ~20y, then decline again in older adults. Basal expenditures for infants and children not in the doubly labeled water database are shown in gray. C. Pregnant mothers exhibit adjusted total and basal expenditures similar to non-reproducing adults (Pre: prior to pregnancy; Post: 27 weeks post-partum). D. Segmented regression analysis of adjusted total (red) and adjusted basal expenditure (calculated as a portion of total; Adj. BEETEE; black) indicates a peak at ~1 y, adult levels at ~20 y, and decline at ~60 y (see text).
Figure 3.
Figure 3.
Modeling the contribution of physical activity and tissue-specific metabolism to daily expenditures. A. Observed total (TEE, red), basal (BEE, black), and activity (AEE, gray) expenditures (Table S1) show age-related variation with respect to fat free mass (see Figure 1C) that is also evident in adjusted values (Table S3; see Figure 2D). B. These age effects do not emerge in models assuming constant physical activity (PA, green) and tissue-specific metabolic rate (TM, black) across the life course. C. When physical activity and tissue-specific metabolism follow the life course trajectories evident from accelerometry and adjusted basal expenditure, respectively, model output is similar to observed expenditures.

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