Plant-based diets, pescatarian diets and COVID-19 severity: a population-based case-control study in six countries

Abstract

Background: Several studies have hypothesised that dietary habits may play an important role in COVID-19 infection, severity of symptoms, and duration of illness. However, no previous studies have investigated the association between dietary patterns and COVID-19.

Methods: Healthcare workers (HCWs) from six countries (France, Germany, Italy, Spain, UK, USA) with substantial exposure to COVID-19 patients completed a web-based survey from 17 July to 25 September 2020. Participants provided information on demographic characteristics, dietary information, and COVID-19 outcomes. We used multivariable logistic regression models to evaluate the association between self-reported diets and COVID-19 infection, severity, and duration.

Results: There were 568 COVID-19 cases and 2316 controls. Among the 568 cases, 138 individuals had moderate-to-severe COVID-19 severity whereas 430 individuals had very mild to mild COVID-19 severity. After adjusting for important confounders, participants who reported following 'plant-based diets' and 'plant-based diets or pescatarian diets' had 73% (OR 0.27, 95% CI 0.10 to 0.81) and 59% (OR 0.41, 95% CI 0.17 to 0.99) lower odds of moderate-to-severe COVID-19 severity, respectively, compared with participants who did not follow these diets. Compared with participants who reported following 'plant-based diets', those who reported following 'low carbohydrate, high protein diets' had greater odds of moderate-to-severe COVID-19 (OR 3.86, 95% CI 1.13 to 13.24). No association was observed between self-reported diets and COVID-19 infection or duration.

Conclusion: In six countries, plant-based diets or pescatarian diets were associated with lower odds of moderate-to-severe COVID-19. These dietary patterns may be considered for protection against severe COVID-19.

Keywords: COVID-19; dietary patterns.

Conflict of interest statement

Competing interests: None declared.

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

Figures

Figure 1

Adjusted odds ratios (ORs) and 95% confidence intervals (95% CI) for the association between self-reported dietary patterns and moderate-to-severe COVID-19. ORs of moderate-to-severe COVID-19 for those who followed low carbohydrate, high protein diets were 3.55 (95% CI 1.06 to 11.82) in model 1, 3.86 (95% CI 1.13 to 13.24) in model 2, and 3.96 (95% CI 1.14 to 13.75) in model 3 (p0.05 for all tests), compared with those who followed plant-based diets or pescatarian diets. We compared moderate-to-severe severity to very mild to mild severity. ‘Very mild’ severity was defined as asymptomatic or nearly asymptomatic. ‘Mild’ severity was defined as symptoms (fever 2) <93% at rest; (3) partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ≤300 mm Hg. Model 1 adjusted for age, sex, race/ethnicity, and country. Model 2 additionally adjusted for specialty, smoking, and physical activity. Model 3 additionally adjusted for body mass index and presence of a medical condition.