ACE1 polymorphism and progression of SARS

Satoru Itoyama, Naoto Keicho, Tran Quy, Nguyen Chi Phi, Hoang Thuy Long, Le Dang Ha, Vo Van Ban, Jun Ohashi, Minako Hijikata, Ikumi Matsushita, Akihiko Kawana, Hideki Yanai, Teruo Kirikae, Tadatoshi Kuratsuji, Takehiko Sasazuki, Satoru Itoyama, Naoto Keicho, Tran Quy, Nguyen Chi Phi, Hoang Thuy Long, Le Dang Ha, Vo Van Ban, Jun Ohashi, Minako Hijikata, Ikumi Matsushita, Akihiko Kawana, Hideki Yanai, Teruo Kirikae, Tadatoshi Kuratsuji, Takehiko Sasazuki

Abstract

We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p=0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.

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