Local variations in CO and particulate air pollution and adverse birth outcomes in Los Angeles County, California, USA

Michelle Wilhelm, Beate Ritz, Michelle Wilhelm, Beate Ritz

Abstract

We extended our previous analyses of term low birth weight (LBW) and preterm birth to 1994-2000, a period of declining air pollution levels in the South Coast Air Basin. We speculated that the effects we observed previously for carbon monoxide, particulate matter < 10 microm in aerodynamic diameter (PM10), and traffic density were attributable to toxins sorbed to primary exhaust particles. Focusing on CO, PM10, and particulate matter < 2.5 microm in aerodynamic diameter (PM2.5), we examined whether varying residential distances from monitoring stations affected risk estimates, because effect attenuation may result from local pollutant heterogeneity inadequately captured by ambient stations. We geocoded home locations, calculated the distance to the nearest air monitors, estimated exposure levels by pregnancy period, and performed logistic regression analyses for subjects living within 1-4 mi of a station. For women residing within a 1-mi distance, we observed a 27% increase in risk for high (> or = 75th percentile) first-trimester CO exposures and preterm birth and a 36% increase for high third-trimester pregnancy CO exposures and term LBW. For particles, we observed similar size effects during early and late pregnancy for both term LBW and preterm birth. In contrast, smaller or no effects were observed beyond a 1-mi distance of a residence from a station. Associations between CO and PM10 averaged over the whole pregnancy and term LBW were generally smaller than effects for early and late pregnancy. These new results for 1994-2000 generally confirm our previous observations for the period 1989-1993, again linking CO and particle exposures to term LBW and preterm birth. In addition, they confirm our suspicions about having to address local heterogeneity for these pollutants in Los Angeles.

Figures

Figure 1
Figure 1
Location of SoCAB monitoring stations measuring CO and PM10 and CO only: ZIP-code–level analysis.
Figure 2
Figure 2
Location of LA County monitoring stations measuring CO and PM10 and CO only: address-level analysis.

References

    1. Bobak M. Outdoor air pollution, low birth weight, and prematurity. Environ Health Perspect. 2000;108:173–176.
    1. Chen L, Yang W, Jennison BL, Goodrich A, Omaye ST. Air pollution and birth weight in northern Nevada, 1991–1999. Inhal Toxicol. 2002;14:141–157.
    1. Dejmek J, Selevan SG, Benes I, Solanksy I, Śrám RJ. Fetal growth and maternal exposure to particulate matter during pregnancy. Environ Health Perspect. 1999;107:475–480.
    1. Dejmek J, Solansky I, Benes I, Lenicek J, Śrám RJ. The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome. Environ Health Perspect. 2000;108:1159–1164.
    1. Englert N. Fine particles and human health—a review of epidemiological studies. Toxicol Lett. 2004;149:235–242.
    1. Glinianaia SV, Rankin J, Bell R, Pless-Mulloli T, Howel D. Particulate air pollution and fetal health: a systematic review of the epidemiologic evidence. Epidemiology. 2004;15:36–45.
    1. Gouveia N, Bremner SA, Novaes HM. Association between ambient air pollution and birth weight in Sao Paulo, Brazil. J Epidemiol Community Health. 2004;58:11–17.
    1. Guyda, HJ Metabolic effects of growth factors and polycyclic aromatic hydrocarbons on cultured human placental cells of early and late gestation. J Clin Endocrinol Metab. 1991;72:718–723.
    1. Ha EH, Hong YC, Lee BE, Woo BH, Schwartz J, Christiani DC. Is air pollution a risk factor for low birth weight in Seoul? Epidemiology. 2001;12:643–648.
    1. Hitchins J, Morawska L, Wolff R, Gilbert D. Concentrations of submicrometre particles from vehicle emissions near a major road. Atmos Environ. 2000;34:51–59.
    1. Hobel CJ, Dunkel-Schetter C, Roesch SC, Castro LC, Arora CP. Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks’ gestation in pregnancies ending in preterm delivery. Obstet Gynecol. 1999;189:S257–S263.
    1. Ibald-Mulli A, Wichmann HE, Kreyling W, Peters A. Epidemiological evidence on health effects of ultrafine particles. J Aerosol Med. 2002;15:189–201.
    1. Jaques PA, Kim CS. Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women. Inhal Toxicol. 2000;12:715–731.
    1. Kim S, Shen S, Sioutas C, Zhu YF, Hinds WC. Size distribution and diurnal and seasonal trends of ultrafine particles in source and receptor sites of the Los Angeles Basin. J Air Waste Manag Assoc. 2002;52:297–307.
    1. Kline J, Stein Z, Susser M. 1989. Conception to Birth. Epidemiology of Prenatal Development. New York:Oxford Press.
    1. Lee BE, Ha EH, Park HS, Kim YJ, Hong YC, Kim HM, et al. Exposure to air pollution during different gestational phases contributes to risks of low birth weight. Hum Reprod. 2003;18:638–643.
    1. Liu S, Krewski D, Shi Y, Chen Y, Burnett RT. Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada. Environ Health Perspect. 2003;111:1773–1778.
    1. Maisonet M, Bush TJ, Correa A, Jaakkola JJ. Relation between ambient air pollution and low birth weight in the northeastern United States. Environ Health Perspect. 2001;109:351–356.
    1. Maisonet M, Correa A, Misra D, Jaakkola JJ. A review of the literature on the effects of ambient air pollution on fetal growth. Environ Res. 2004;95:106–115.
    1. Maroziene L, Grazuleviciene R. Maternal exposure to low-level air pollution and pregnancy outcomes: a population-based study. Environ Health. 2002;1:1–7.
    1. Morawska L, Thomas S, Gilbert D, Greenaway C, Rijnders E. A study of the horizontal and vertical profile of submicrometer particles in relation to a busy road. Atmos Environ. 1999;33:1261–1274.
    1. Oberdörster G, Utell MJ. Ultrafine particles in the urban air: to the respiratory tract—and beyond? Environ Health Perspect. 2002;110:A440–A441.
    1. Perera FP, Rauh V, Tsai WY, Kinney PL, Camann D, Barr D, et al. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environ Health Perspect. 2003;111:201–205.
    1. Perera FP, Whyatt RM, Jedrychowski W, Rauh V, Manchester D, Santella RM, et al. Recent developments in molecular epidemiology: a study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland. Am J Epidemiol. 1998;147:309–314.
    1. Platt R, Joseph K, Ananth CV, Grondines J, Abrahamowicz M, Kramer MS. A proportional hazards model with time-dependent covariates and time-varying effects for analysis of fetal and infant death. Am J Epidemiol. 2004;160:199–206.
    1. Ritz B, Yu F. The effect of ambient carbon monoxide on low birth weight among children born in southern California between 1989 and 1993. Environ Health Perspect. 1999;107:17–25.
    1. Ritz B, Yu F, Chapa G, Fruin S. Effect of air pollution on preterm birth among children born in southern California between 1989 and 1993. Epidemiology. 2000;11:502–511.
    1. Ritz B, Yu F, Fruin S, Chapa G, Shaw GM, Harris JA. Ambient air pollution and risk of birth defects in southern California. Am J Epidemiol. 2002;155:17–25.
    1. Schauer JJ, Rogge WF, Hildeman LM, Mazurek MA, Cass GR, Simoneit BRT. Source apportionment of airborne particulate matter using organic compounds as tracers. Atmos Environ. 1996;30:3837–3855.
    1. Shi JP, Evans D, Khan AA, Harrison RM. Source and concentration of nanoparticles (< 10 nm diameter) in the urban atmosphere. Atmos Environ. 2001;35:1193–1202.
    1. Shi JP, Khan AA, Harrison RM. Measurements of ultrafine particle concentration and size distribution in the urban atmosphere. Sci Total Environ. 1999;235:51–64.
    1. Topinka J, Binkova B, Mrackova G, Stavkova Z, Peterka V, Benes I, et al. Influence of GSTM1 and NAT2 genotypes on placental DNA adducts in an environmentally exposed population. Environ Mol Mutagen. 1997;30:184–195.
    1. U.S. Census Bureau 2004. 2000 Census of Population and Housing. Summary Tape File 3A. Washington, DC:U.S. Census Bureau.
    1. Vassilev ZP, Robson MG, Klotz JB. Outdoor exposure to airborne polycyclic organic matter and adverse reproductive outcomes: a pilot study. Am J Ind Med. 2001a;40:255–262.
    1. Vassilev ZP, Robson MG, Klotz JB. Associations of polycyclic organic matter in outdoor air with decreased birth weight: a pilot cross-sectional analysis. J Toxicol Environ Health. 2001b;64:595–605.
    1. Wadhwa PD, Culhane JF, Rauh V, Barve SS, Hogan V, Sandman CA, et al. Stress, infection and preterm birth: a bio-behavioural perspective. Paediatr Perinat Epidemiol. 2001;15:17–29.
    1. Wang X, Ding H, Ryan L, Xu X. Association between air pollution and low birth weight: a community- based study. Environ Health Perspect. 1997;105:514–520.
    1. Wilhelm M, Ritz B. Residential proximity to traffic and adverse birth outcomes in Los Angeles County, California, 1994–1996. Environ Health Perspect. 2003;111:207–216.
    1. Woodruff TJ, Parker JD, Kyle AD, Schoendorf KC. Disparities in exposure to air pollution during pregnancy. Environ Health Perspect. 2003;111:942–946.
    1. Xu X, Ding H, Wang X. Acute effects of total suspended particles and sulfur dioxides on preterm delivery: a community-based cohort study. Arch Environ Health. 1995;50:407–415.
    1. Yang CY, Tseng YT, Chang CC. Effects of air pollution on birth weight among children born between 1995 and 1997 in Kaohsiung, Taiwan. J Toxicol Environ Health. 2003;66:807–816.
    1. Yeh HC, Muggenburg BA, Harkema JR. In vivo deposition of inhaled ultrafine particles in the respiratory tract of rhesus monkeys. Aerosol Sci Technol. 1997;27:465–470.
    1. Zhang L, Conner EE, Chegini N, Shiverick KT. Modulation by benzo(a)pyrene of epidermal growth factor receptors, cell proliferation, and secretion of human chorionic gonadotropin in human placental lines. Biochem Pharmacol. 1995;50:1171–1180.
    1. Zhu YF, Hinds WC, Kim S, Shen S, Sioutas C. Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmos Environ. 2002a;36:4323–4335.
    1. Zhu YF, Hinds WC, Kim S, Sioutas C. Concentration and size distribution of ultrafine particles near a major highway. J Air Waste Manag Assoc. 2002b;52:1032–1042.

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