Positive Modulation Effect of 8-Week Consumption of Kaempferia parviflora on Health-Related Physical Fitness and Oxidative Status in Healthy Elderly Volunteers

Jintanaporn Wattanathorn, Supaporn Muchimapura, Terdthai Tong-Un, Narisara Saenghong, Wipawee Thukhum-Mee, Bungorn Sripanidkulchai, Jintanaporn Wattanathorn, Supaporn Muchimapura, Terdthai Tong-Un, Narisara Saenghong, Wipawee Thukhum-Mee, Bungorn Sripanidkulchai

Abstract

Health-related physical fitness declines as the age advances. Oxidative stress is reported to contribute the crucial role on this phenomenon. This condition is also enhanced by antioxidant. Therefore, we aimed to determine the effect of Kaempferia parviflora, a plant reputed for antifatigue, longevity promotion, and antioxidant effects, on health-related quality physical fitness and oxidative status of the healthy elderly volunteers. Total 45 subjects had been randomized to receive placebo or K. parviflora extract at doses of 25 or 90 mg once daily for 8 weeks. They were determined baseline data of physical performance using 30 sec chair stand test, hand grip test, 6 min walk test, and tandem test. Serum oxidative stress markers including malondialdehde (MDA) level and the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were also assayed. All assessments were performed every 4 weeks throughout the 8-week study period. The results showed that K. parviflora increased performance in 30-second chair stand test and 6 min walk test together with the increased all scavenger enzymes activities and the decreased MDA level. Therefore, K. parviflora can enhance physical fitness partly via the decreased oxidative stress. In conclusion, K. parviflora is the potential health supplement for elderly. However, further study is required.

Figures

Figure 1
Figure 1
Effect of various doses of K. parviflora on level of superoxide dismutase in serum. Data were present as mean ± SEM (n = 15/group). ∗∗,∗∗∗P value <0.01; 0.001 compared with placebo group, respectively. #,###P value <0.05; 0.01 compared to baseline, respectively.
Figure 2
Figure 2
Effect of various doses of K. parviflora on level of catalase in serum. Data were present as mean ± SEM (n = 15/group). ∗∗,∗∗∗P value <0.01; 0.001 compared with placebo group, respectively. ###P value <0.001 compared to baseline.
Figure 3
Figure 3
Effect of various doses of K. parviflora on level of glutathione peroxidase in serum. Data were present as mean ± SEM (n = 15/group). *P value <0.05 compared with placebo group. ##P value <0.01 compared to baseline.
Figure 4
Figure 4
Effect of various doses of K. parviflora on level of malondialdehyde (MDA) in serum. Data were present as mean ± SEM (n = 15/group). **P value <0.01 compared with placebo group. #P value <0.05 compared to baseline.
Figure 5
Figure 5
Schematic diagram illustrated the possible action of K. parviflora on muscle strength of lower extremities and aerobic endurance.

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