STATing the importance of immune modulation by platinum chemotherapeutics
Stanleyson V Hato, I Jolanda M de Vries, W Joost Lesterhuis, Stanleyson V Hato, I Jolanda M de Vries, W Joost Lesterhuis
Abstract
Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these drugs in combination with other immunostimulatory compounds.
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References
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Source: PubMed