Surgical Outcomes After Pancreatic Resection of Screening-Detected Lesions in Individuals at High Risk for Developing Pancreatic Cancer
Marcia Irene Canto, Tossapol Kerdsirichairat, Charles J Yeo, Ralph H Hruban, Eun Ji Shin, Jose Alejandro Almario, Amanda Blackford, Madeline Ford, Alison P Klein, Ammar A Javed, Anne Marie Lennon, Atif Zaheer, Ihab R Kamel, Elliot K Fishman, Richard Burkhart, Jin He, Martin Makary, Matthew J Weiss, Richard D Schulick, Michael G Goggins, Christopher L Wolfgang, Marcia Irene Canto, Tossapol Kerdsirichairat, Charles J Yeo, Ralph H Hruban, Eun Ji Shin, Jose Alejandro Almario, Amanda Blackford, Madeline Ford, Alison P Klein, Ammar A Javed, Anne Marie Lennon, Atif Zaheer, Ihab R Kamel, Elliot K Fishman, Richard Burkhart, Jin He, Martin Makary, Matthew J Weiss, Richard D Schulick, Michael G Goggins, Christopher L Wolfgang
Abstract
Background: Screening high-risk individuals (HRI) can detect potentially curable pancreatic ductal adenocarcinoma (PDAC) and its precursors. We describe the outcomes of high-risk individuals (HRI) after pancreatic resection of screen-detected neoplasms.
Methods: Asymptomatic HRI enrolled in the prospective Cancer of the Pancreas Screening (CAPS) studies from 1998 to 2014 based on family history or germline mutations undergoing surveillance for at least 6 months were included. Pathologic diagnoses, hospital length of stay, incidence of diabetes mellitus, operative morbidity, need for repeat operation, and disease-specific mortality were determined.
Results: Among 354 HRI, 48 (13.6%) had 57 operations (distal pancreatectomy (31), Whipple (20), and total pancreatectomy (6)) for suspected pancreatic neoplasms presenting as a solid mass (22), cystic lesion(s) (25), or duct stricture (1). The median length of stay was 7 days (IQR 5-11). Nine of the 42 HRI underwent completion pancreatectomy for a new lesion after a median of 3.8 years (IQR 2.5-7.6). Postoperative complications developed in 17 HRI (35%); there were no perioperative deaths. New-onset diabetes mellitus after partial resection developed in 20% of HRI. Fourteen PDACs were diagnosed, 11 were screen-detected, 10 were resectable, and 9 had an R0 resection. Metachronous PDAC developed in remnant pancreata of 2 HRI. PDAC-related mortality was 4/10 (40%), with 90% 1-year survival and 60% 5-year survival, respectively.
Conclusions: Screening HRI can detect PDAC with a high resectability rate. Surgical treatment is associated with a relatively short length of stay and low readmission rate, acceptable morbidity, zero 90-day mortality, and significant long-term survival.
Clinical trial registration number: NCT2000089.
Trial registration: ClinicalTrials.gov NCT02000089.
Keywords: Early detection; Pancreatic cancer; Screening; Surgical outcomes.
Source: PubMed