Peanut Oral Immunotherapy: a Current Perspective

Meera Patrawala, Jennifer Shih, Gerald Lee, Brian Vickery, Meera Patrawala, Jennifer Shih, Gerald Lee, Brian Vickery

Abstract

Purpose of the review: Peanut oral immunotherapy (OIT) is one of the most studied experimental therapies for food allergy. With the recently FDA-approved peanut product, Palforzia, the goal of this article is to review the most recent data from clinical trials, discuss recent trends, and anticipate future developments.

Recent findings: The latest research suggests that peanut OIT could be a promising option for peanut-allergic patients, with the majority of participants in research studies achieving the primary efficacy endpoint of desensitization, as well as sustained unresponsiveness in select populations. Some studies also showed improvements in food allergy-related quality of life. However, peanut OIT is not without risk or side effects, including potentially serious allergic reactions. Future research will need to evaluate the short- and long-term effectiveness of the therapy in the real-world setting, predictors of important treatment outcomes, and the use of adjunctive therapies that may mitigate some of these allergic reactions.

Keywords: Desensitization; Food allergy; Oral food challenge; Oral immunotherapy; Peanut allergy; Sustained unresponsiveness.

Conflict of interest statement

Dr. Vickery reports grants and personal fees from Aimmune Therapeutics, personal fees from AllerGenis, grants and personal fees from Food Allergy Research and Education, grants from Genentech, grants from DBV Technologies, grants from NIH-NIAID, grants from Regeneron, outside the submitted work. The other authors declare no conflicts of interest relevant to this manuscript.

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