Predicting First-Year Growth in Response to Growth Hormone Treatment in Prepubertal Korean Children with Idiopathic Growth Hormone Deficiency: Analysis of Data from the LG Growth Study Database

Won Kyoung Cho, Moon Bae Ahn, Eun Young Kim, Kyoung Soon Cho, Min Ho Jung, Byung Kyu Suh, Won Kyoung Cho, Moon Bae Ahn, Eun Young Kim, Kyoung Soon Cho, Min Ho Jung, Byung Kyu Suh

Abstract

Background: The first-year growth in response to growth hormone (GH) treatment seems to be the most important factor in determining the overall success of GH treatment.

Methods: Data from children (n = 345) who were in the LG Growth Study Database were used to develop a model. All subjects had been diagnosed with idiopathic growth hormone deficiency (GHD) and presented in a prepubertal state during the first year of GH treatment.

Results: The Δheight standard deviation score (SDS) during 1st year of GH treatment was correlated positively with weight-SDS (β = 0.304, P < 0.001), body mass index (BMI)-SDS (β = 0.443, P < 0.001), paternal height-SDS (β = 0.296, P = 0.001), MPH-SDS (β = 0.421, P < 0.001) and MPH SDS minus baseline height SDS (β = 0.099, P < 0.001) but negatively with chronological age (β = -0.294, P < 0.001), bone age (β = -0.249, P < 0.001). A prediction model of 1st year growth in response to GH treatment in prepubertal Korean children with idiopathic GHD is as follows: Δheight SDS during 1st year of GH treatment = 1.06 - 0.05 × age + 0.09 × (MPH SDS minus baseline height SDS) + 0.05 × BMI SDS. This model explained 19.6% of the variability in the response, with a standard error of 0.31.

Conclusion: The present model to predict first-year response to GH treatment might allow more tailored and personalized GH treatment in Korean prepubertal children with idiopathic GHD.

Trial registration: ClinicalTrials.gov Identifier: NCT01604395.

Keywords: Growth Hormone Deficiency; Prediction; Treatment.

Conflict of interest statement

EY Kim, 3rd author is a full-time employee of LG Chem, Ltd. Other authors have no potential conflicts of interest to disclose. The LG Chem, Ltd. did not affect overall research integrity including interpretation of the results and manuscript writings.

© 2020 The Korean Academy of Medical Sciences.

Figures

Fig. 1. A flow chart of cohort.…
Fig. 1. A flow chart of cohort. Among the 783 participants, subjects who had received once weekly rhGH injection (n = 115), and/or those with inappropriate auxological data (n = 323) at 12 ± 3 months after GH treatment were excluded. Ultimately, our study population included 345 children (195 males and 150 females).
GHD = growth hormone deficiency, rhGH = recombinant human growth hormone.
Fig. 2. Studentized residuals for prediction model…
Fig. 2. Studentized residuals for prediction model of Δheight SDS. The studentized residuals and predicted value graphs in the validation of prediction models were distributed randomly between −2 and 2, and there were no values outside −3 and 3.
SDS = standard deviation score, MPH = mid-parental height.

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