Cardiovascular risk: the safety of local anesthesia, vasoconstrictors, and sedation in heart disease

R J Middlehurst, A Gibbs, G Walton, R J Middlehurst, A Gibbs, G Walton

Abstract

As part of a large pragmatic study, the authors investigated heart rate, blood pressure, dysrhythmic and ischemic responses to lidocaine 2% with a combination vasoconstrictor (noradrenaline 1:50,000 and vasopressin 0.25 IU/mL), and midazolam sedation in a medically compromised population. There were anesthesia-induced physiological changes to both hemodynamics and the electrocardiogram. The use of midazolam significantly ameliorated the sympathoadrenal response to stress, and the greatest hemodynamic and electrocardiographic changes were observed during surgery.

References

    1. Eur J Oral Sci. 1996 Jun;104(3):245-52
    1. Aust Dent J. 1994 Oct;39(5):282-6
    1. Circulation. 1970 Feb;41(2):173-6
    1. Circulation. 1971 Jul;44(1):130-42
    1. J Oral Surg. 1972 May;30(5):332-43
    1. Br Dent J. 1972 Aug 15;133(4):137-40
    1. Br Med J. 1972 Oct 7;4(5831):7-9
    1. Circulation. 1975 Dec;52(6):1045-9
    1. Am J Cardiol. 1977 Mar;39(3):390-5
    1. J Dent. 1978 Jun;6(2):133-46
    1. J Oral Surg. 1978 Oct;36(10):779-80
    1. Br J Oral Surg. 1981 Mar;19(1):3-12
    1. Am J Cardiol. 1982 May;49(7):1638-42
    1. Br Dent J. 1983 Feb 5;154(3):76-7
    1. Br Dent J. 1983 Apr 23;154(8):253-8
    1. J Am Dent Assoc. 1983 Oct;107(4):623-30
    1. Eur Heart J. 1984 Jan;5(1):7-20
    1. Pain. 1984 Jan;18(1):33-40
    1. Anesth Prog. 1985 Mar-Apr;32(2):47-56
    1. J Oral Maxillofac Surg. 1986 Jun;44(6):441-6
    1. Eur Heart J. 1986 May;7 Suppl A:169-80
    1. J Am Dent Assoc. 1986 Oct;113(4):639-42
    1. J Am Dent Assoc. 1989 Sep;119(3):407-12
    1. Aust Dent J. 1989 Aug;34(4):323-5
    1. Circulation. 1991 Jan;83(1):96-103
    1. J Oral Maxillofac Surg. 1991 Sep;49(9):957-62
    1. Quintessenz. 1991 Jun;42(6):983-90
    1. Oral Surg Oral Med Oral Pathol. 1992 Nov;74(5):679-86
    1. BMJ. 1992 Nov 14;305(6863):1170-1
    1. Circulation. 1993 May;87(5):1442-50
    1. Anesth Prog. 1992;39(3):87-9
    1. Anesth Analg. 1993 Oct;77(4):867-8
    1. Anesth Pain Control Dent. 1993 Spring;2(2):81-6
    1. Am J Physiol. 1965 Apr;208:754-62

Source: PubMed

Sponsorer og samarbeidspartnere

Medisinsk tilstand

Legemiddelintervensjoner

3
Abonnere