Takotsubo cardiomyopathy--a clinical review

Ana María Castillo Rivera, Manuel Ruiz-Bailén, Luis Rucabado Aguilar, Ana María Castillo Rivera, Manuel Ruiz-Bailén, Luis Rucabado Aguilar

Abstract

Stress cardiomyopathy is characterised by reversible left ventricular dysfunction. It simulates an acute coronary syndrome (ACS), presenting with precordial pain or dyspnoea, changes of the ST segment, T wave, or QTc interval on electrocardiogram, and raised cardiac enzymes. Typical findings are disturbances of segmental contractility (apical hypokinesia or akinesia), with normal epicardial coronary arteries. The true prevalence is unknown, as the syndrome may be under-diagnosed; it is more common in postmenopausal women. There is usually a trigger in the form of physical or psychological stress. The electrocardiographic, echocardiographic, and ventriculographic changes resolve spontaneously over a variable period of time (from days to months). There are a number of pathophysiological theories, none of which has been shown to be definitive, suggesting that all of them may be involved to some extent. The prognosis is generally favourable, and recurrence is very rare.

Figures

Figure 1
Figure 1
Echocardiographic image in apical ballooning which is also observed mitral prolapse (P2).
Figure 2
Figure 2
This is hybrid speckle tracking imagen of takotsubo patient. There is a pathological displacement curve in the apical segments and increased in the basal segments.
Figure 3
Figure 3
Ventriculography image of apical ballooning which shows apical akinesia and basal hyperkinesis.

References

    1. Maron BJ, Towbin JA, Thiene G, et al. Contemporary Definitions And Classification Of The Cardiomyopathies: An American Heart Association Scientific Statement From The Council On Clinical Cardiology, Heart Failure And Transplantation Committee; Quality Of Care And Outcomes Research And Functional Genomics And Translational Biology Interdisciplinary Working Groups; And Council On Epidemiology And Prevention. Circulation. 2006;113:1807–16.
    1. Bybee KA, Prasad A. Stress-Related Cardiomyopathy Syndromes. Circulation. 2008;118:397–409.
    1. Abe Y, Kondo M, Matsuoka R, et al. Assessment of Clinical Features in Transient Left Ventricular Apical Ballooning. J Am Coll Cardiol. 2003;41:737–42.
    1. Abe Y, Kondo M. Apical Ballooning Of The Left Ventricle: A Distinct Entity? Heart. 2003;89:974–76.
    1. Bybee KA, Kara T, Prasad A, et al. Systematic Review: Transient Left Ventricular Apical Ballooning: A Syndrome That Mimics ST-Segment Elevation Myocardial Infarction. Ann Intern Med. 2004;141:858–65.
    1. Prasad A. Apical Ballooning Syndrome. An Important Differential Diagnosis of Acute Myocardial Infarction. Circulation. 2007;115:e56–59.
    1. Segovia Cubero J, Peraira Moral R. Transient apical ballooning syndrome: a transition towards adulthood. Rev Esp Cardiol. 2004;57:194–97. [in Spanish with English abstract]
    1. Kawai S, Kitabatake A, Tomoike H, et al. Guidelines For Diagnosis Of Takotsubo (Ampulla) Cardiomyopathy. Circ J. 2007;71:990–92.
    1. Ishikawa K. “Takotsubo” Cardiomyopathy A Syndrome Characterized by Transient Left Ventricular Apical Ballooning that Mimics the Shape of a Bottle Used for Trapping Octopus in Japan. Intern Med. 2004;43:275–76.
    1. Inoue F, Takaoka M, Kumura H, et al. So-Called “Ampulla” Cardiomyopathy Associated with Vasospasm Compared with Acute Myocardial Infarction Showing Similar Abnormal Left Ventricular Wall Motion: Two Case Reports. J Cardiol. 2002;39:29–38. [in Japanese with English abstract]
    1. Kawai S, Suzuki H, Yamaguchi H, et al. Ampulla Cardiomyopathy (“Takotsubo” Cardiomyopathy) – Reversible Left Ventricular Dysfunction: with ST Segment Elevation. Jpn Circ J. 2000;64:156–59.
    1. Owa M, Aizawa K, Urasawa N, et al. Emotional Stress-Induced “Ampulla Cardiomyopathy”: Discrepancy Between the Metabolic and Sympathetic Innervation Imaging Performed During the Recovery Course. Jpn Circ J. 2001;65:349–52.
    1. Yamasa T, Ikeda S, Ninomiya A, et al. Characteristic Clinical Findings of Reversible Left Ventricular Dysfunction. Intern Med. 2002;41:789–92.
    1. Movahed MR, Donohue D. Review: Transient Left Ventricular Apical Ballooning, Broken Heart Syndrome, Ampulla Cardiomyopathy, Atypical Apical Ballooning, or Tako-Tsubo Cardiomyopathy. Cardiovasc Revasc Med. 2007;8:289–92.
    1. Tsuchihashi K, Ueshima K, Uchida T, et al. Transient Left Ventricular Apical Ballooning without Coronary Artery Stenosis: A Novel Herat Syndrome Mimicking Acute Myocardial Infarction. Angina Pectoris Myocardial Infarction Investigations in Japan. J Am Coll Cardiol. 2001;38:11–18.
    1. Pavin D, Le Breton H, Daubert C. Human Stress Cardiomyopathy Mimicking Acute Myocardial Syndrome. Heart. 1997;78:509–11.
    1. Sharkey SW, Lesser JR, Maron MS. Stress Cardiomyopathy. J Am Coll Cardiol. 2007;49:921.
    1. Brandspiegel HZ, Marinchak RA, Rials SJ, et al. A Broken Heart. Circulation. 1998;98:1349.
    1. Khallafi H, Chacko V, Varveralis N, et al. “Broken Heart Syndrome”: Catecholamine Surge Or Aborted Myocardial Infarction? J Invasive Cardiol. 2008;20:e9–13.
    1. Gueffet JP, Langlard JM, Burban M, et al. Can One Die of Sorrow? Arch Mal Coeur Vaiss. 2001;94:1413–17. [in French with English abstract]
    1. Dote K, Sato H, Tateishi H, et al. Myocardial Stunning Due to Simultaneous Multivessel Coronary Spasms: A Review of Five Cases. J Cardiol. 1991;21:203–14. [in Japanese with English abstract]
    1. Desmet WJ, Adriaenssens BF, Dens JA. Apical Ballooning of the Left Ventricle: First Series in White Patients. Heart. 2003;89:1027–31.
    1. Hertting K, Krause K, Härle T, et al. Transient Left Ventricular Ballooning In A Community Hospital In Germany. Int J Cardiol. 2006;112:282–88.
    1. Kurisu S, Sato H, Kawagoe T, et al. Tako-Tsubo-Like Left Ventricular Dysfunction With ST-Segment Elevation: A Novel Cardiac Syndrome Mimicking Acute Myocardial Infarction. Am Heart J. 2002;143:448–55.
    1. Sharkey SW, Lesser JR, Zenovich AG, et al. Acute and Reversible Cardiomyopathy Provoked By Stress in Women from the United States. Circulation. 2005;111:472–79.
    1. Wittstein IS, Thiemann DR, Lima JA, et al. Neurohumoral Features Of Myocardial Stunning Due To Sudden Emotional Stress. N Eng J Med. 2005;352:539–48.
    1. Akashi YJ, Nakazawa K, Sakakibara M, et al. The Clinical Features Of Takotsubo Cardiomyopathy. Q J Med. 2003;96:563–73.
    1. Donohue D, Ahsan C, Sanaei-Ardekani M, et al. Early Diagnosis Of Stress-Induced Apical Ballooning Syndrome Based On Classic Echocardiographic Findings And Correlation With Cardiac Catheterization. J Am Soc Echocardiogr. 2005;18:1423.e15–e22.
    1. Guevara R, Aguinaga-Meza M, Hazin MI, et al. Takotsubo Cardiomyopathy Complicated With Acute Pericarditis And Cardiogenic Shock. J Natl Med Assoc. 2007;99:281–83.
    1. Hurst RT, Askew JW, Reuss CS, et al. Transient Midventricular Ballooning Syndrome. A New Variant. J Am Coll Cardiol. 2006;48:579–83.
    1. Patel HM, Kantharia BK, Morris DL, et al. Takotsubo Syndrome in African-American Women with Atypical Presentations: A Single-Center Experience. Clin Cardiol. 2007;30:14–18.
    1. Seth PS, Aurigemma GP, Krasnow JM, et al. A Syndrome of Transient Left Ventricular Apical Wall Motion Abnormality in the Absence of Coronary Disease: A Perspective from the United States. Cardiology. 2003;100:61–66.
    1. Athanasiadis A, Vogelsberg H, Hauer B, et al. Transient Left Ventricular Dysfunction with Apical Ballooning (Tako-Tsubo Cardiomyopathy) in Germany. Clin Res Cardiol. 2006;95:321–28.
    1. Azzarelli S, Galassi AR, Amico F, et al. Clinical Features of Transient Left Ventricular Apical Ballooning. Am J Cardiol. 2006;98:1273–76.
    1. Cangella F, Medolla A, De Fazio G, et al. Stress Induced Cardiomyopathy Presenting as Acute Coronary Syndrome: Tako-Tsubo In Mercogliano, Southern Italy. Cardiovasc Ultrasound. 2007;5:36.
    1. Ruiz Bailén M, Aguayo De Hoyos E, López Martínez A, et al. Reversible Myocardial Dysfunction, a Possible Complication in Critically Ill Patients without Heart Disease. J Crit Care. 2003;18:245–52.
    1. Marcu C, Balf D, Donohue T. Medical Image. Takotsubo Cardiomyopathy (Left Ventricular Apical Ballooning) N Z Med J. 2005;118:1208–9.
    1. Abdulla I, Kay S, Mussap C, et al. Apical Sparing In Tako-Tsubo Cardiomyopathy. Intern Med J. 2006;36:414–18.
    1. Akashi YJ, Nakazawa K, Sakakibara M, et al. 123I-MIBG Myocardial Scintigraphy In Patients With “Takotsubo” Cardiomyopathy. J Nucl Med. 2004;45:1121–27.
    1. Hansen PR. Takotsubo Cardiomyopathy: An Under-Recognized Myocardial Syndrome. Eur J Intern Med. 2007;18:561–65.
    1. Parodi G, Del Pace S, Carrabba N, et al. Incidence, Clinical Findings, And Outcome Of Women With Left Ventricular Apical Ballooning Syndrome. Am J Cardiol. 2007;99:182–85.
    1. Pillière R, Mansencal N, Digne F, et al. Prevalence of Tako-Tsubo Syndrome in a Large Urban Agglomeration. Am J Cardiol. 2006;98:662–65.
    1. Strunk B, Shaw RE, Bull S, et al. High Incidence Of Focal Left Ventricular Wall Motion Abnormalities And Normal Coronary Arteries In Patients With Myocardial Infarctions Presenting To A Community Hospital. J Invasive Cardiol. 2006;18:376–81.
    1. Brenner ZR, Powers J. Takotsubo Cardiomyopathy. Heart Lung. 2008;37:1–7.
    1. Klinceva M, Widimský P, Pesl L, et al. Prevalence Of Stress-Induced Myocardial Stunning (Tako-Tsubo Cardiomyopathy) Among Patients Undergoing Emergency Coronary Angiography For Suspected Acute Myocardial Infarction. Int J Cardiol. 2007;120:411–13.
    1. Akashi YJ, Musha H, Kida K, et al. Reversible Ventricular Dysfunction Takotsubo Cardiomyopathy. Eur J Heart Fail. 2005;7:1171–76.
    1. Bonnemeier H, Ortak J, Bode F, et al. Modulation of Ventricular Repolarization in Patients with Transient Left Ventricular Apical Ballooning: A Case Control Study. J Cardiovasc Electrophysiol. 2006;17:1340–47.
    1. Elesber A, Lerman A, Bybee KA, et al. Myocardial Perfusion in Apical Ballooning Syndrome Correlate of Myocardial Injury. Am Heart J. 2006;152:469.e9–13.
    1. Elesber AA, Prasad A, Lennon RJ, et al. Four-Year Recurrence Rate And Prognosis Of The Apical Ballooning Syndrome. J Am Coll Cardiol. 2007;50:448–52.
    1. Fazio G, Barbaro G, Sutera L, et al. Clinical Findings of Takotsubo Cardiomyopathy: Results from a Multicenter International Study. J Cardiovasc Med. 2008;9:239–44.
    1. Spedicato L, Zanuttini D, Nucifora G, et al. Transient Left Ventricular Apical Ballooning Syndrome: A 4-Year Experience. J Cardiovasc Med. 2008;9:916–21.
    1. Ennezat PV, Pesenti-Rossi D, Aubert JM, et al. Transient Left Ventricular Basal Dysfunction without Coronary Stenosis in Acute Cerebral Disorders: A Novel Heart Syndrome (Inverted Takotsubo) Echocardiography. 2005;22:559–602.
    1. Giordan M, Rigatelli G, Cardaioli P, et al. Angiographic Long-Term Follow-Up of Primary Apical Ballooning of the Left Ventricle. Int J Cardiovasc Imaging. 2006;22:349–52.
    1. Bahlmann E, Schneider C, Krause K, et al. Tako-Tsubo Cardiomyopathy Characteristics in Long-Term Follow-Up. Int J Cardiol. 2008;124:32–39.
    1. Buja P, Zuin G, Di Pede F, et al. Long-Term Outcome and Sex Distribution across Ages of Left Ventricular Apical Ballooning Syndrome. J Cardiovasc Med. 2008;9:905–9.
    1. Bybee KA, Murphy J, Prasad A, et al. Acute Impairment of Regional Myocardial Glucose Uptake in the Apical Ballooning (Takotsubo) Syndrome. J Nucl Cardiol. 2006;13:244–50.
    1. Consales G, Campiglia L, Michelagnoli G, et al. Acute Left Ventricular Dysfunction Due To Tako-Tsubo Syndrome after Induction of General Anesthesia. Minerva Anestesiol. 2007;73:655–58.
    1. Haghi D, Fluechter S, Suselbeck T, et al. Cardiovascular Magnetic Resonance Findings in Typical Versus Atypical Forms of the Acute Apical Ballooning Syndrome (Takotsubo Cardiomyopathy) Int J Cardiol. 2007;120:205–11.
    1. Haghi D, Papavassiliu T, Hamm K, et al. Coronary Artery Disease in Takotsubo Cardiomyopathy. Circ J. 2007;71:1092–94.
    1. Inoue M, Shimizu M, Ino H, et al. Differentiation between Patients with Takotsubo Cardiomyopathy and those with Anterior Acute Myocardial Infarction. Circ J. 2005;69:89–94.
    1. Merli E, Sutcliffe S, Gori M, et al. Tako-Tsubo Cardiomyopathy: New Insights into the Possible Underlying Pathophysiology. Eur J Echocardiography. 2006;7:53–61.
    1. Mitsuma W, Kodama M, Ito M, et al. Serial Electrocardiographic Findings In Women With Takotsubo Cardiomyopathy. Am J Cardiol. 2007;100:106–9.
    1. Cherian J, Angelis D, Filiberti A, et al. Can Takotsubo Cardiomyopathy Be Familial? Int J Cardiol. 2007;121:74–75.
    1. Cocco G, Chu D. Stress-Induced Cardiomyopathy: A Review. Eur J Int Med. 2007;18:369–79.
    1. Obón Azuara B, Ortas Nadal MR, Gutiérrez Cía I, et al. Takotsubo cardiomyopathy: transient apical dysfunction of the left ventricle. Med Intensiva. 2007;31:146–52. [in Spanish with English abstract]
    1. Donohue D, Movahed MR. Clinical Characteristics, Demographics and Prognosis of Transient Left Ventricular Apical Ballooning Syndrome. Heart Fail Rev. 2005;10:311–16.
    1. Summers MR, Lennon RJ. Prasad. Pre-morbid psychiatric and cardiovascular diseases in apical ballooning syndrome (tako-tsubo/stress-induced cardiomyoapthy) potential pre-disposing factors? J Am coll Cardiol. 2010;55:700–1.
    1. Parodi G, Del Pace S, Salvadori C, et al. Left Ventricular Apical Ballooning Syndrome as a Novel Cause of Acute Mitral Regurgitation. J Am Coll Cardiol. 2007;50:647–49.
    1. Matsuoka H, Kawakami H, Koyama Y, et al. “Takotsubo” Cardiomyopathy With A Significant Pressure Gradient In The Left Ventricle. Heart Vessels. 2000;15:203.
    1. Raddino R, Pedrinazzi C, Zanini G, et al. Out-Of-Hospital Cardiac Arrest Caused By Transient Left Ventricular Apical Ballooning Syndrome. Int J Cardiol. 2008;128:e31–e33.
    1. Soni A, LeLorier P. Sudden Death in Nondilated Cardiomyopathies: Pathophysiology and Prevention. Current Heart Failure Reports. 2005;2:118–23.
    1. Good CW, Hubbard CR, Harrison TA, et al. Echocardiographic guidance in treatment of cardiogenic shock complicating transient left ventricular apical ballooning syndrome. JACC Cardiovasc Imaging. 2009;2:372–74.
    1. Yaghoubi AR, Ansarin K, Hashemzadehs, et al. Tako-tsubo cardiomyopathy induced by emotional stress leading to severe mitral regurgitation, cardiogenic shock and cardiopulmonary arrest. Int J Cardiol. 2009;135:e85–86.
    1. Blessing E, Steen H, Rosenberg M, et al. Recurrence of Takotsubo Cardiomyopathy with Variant Forms of Left Ventricular Dysfunction. J Am Soc Echocardiogr. 2007;20:439.e11–e12.
    1. Bennett JR, McCarty D, Wilson CM, et al. Takotsubo Cardiomyopathy: An uncommon Cause of ST Segment Elevation in Intensive Care. Anaesthesia. 2007;62:279–81.
    1. Finsterer J, Stöllberger C, Sehnal E, et al. Apical Ballooning (Takotsubo Syndrome) In Mitochondrial Disorder During Mechanical Ventilation. J Cardiovasc Med. 2007;8:859–63.
    1. Kolkebeck TE, Cotant CL, Krasuski RA. Takotsubo Cardiomyopathy: An Unusual Syndrome Mimicking an ST-Elevation Myocardial Infarction. Am J Emerg Med. 2007;25:92–95.
    1. Syed FF, Asirvatham SJ, Francis J. Arrhythmia occurrence with takotsubo cardiomyopathy: a literature review. Europace. 2010 Epub ahead of print.
    1. Ziegelstein RC. Acute Emotional Stress and Cardiac Arrhythmias. JAMA. 2007;298:324–29.
    1. Furushima H, Chinushi M, Sanada A, et al. Ventricular Repolarization Gradients In A Patient With Takotsubo Cardiomyopathy. Europace. 2008;10:1112–15.
    1. Fischer R, Schirdewan A, Kumar A, et al. Cardiac Magnetic Resonance And Cardiac Magnetic Field Mapping In A Patient With Stress-Induced Cardiomyoapthy (Tako-Tsubo) Pacing Clin Electrophysiol. 2006;29:1442–44.
    1. Konety SH, Horwitz P, Lindower P, et al. Arrhythmias in Tako-Tsubo Syndrome-Benign or Malignant? Int J Cardiol. 2007;114:141–44.
    1. Kurisu S, Inoue I, Kawagoe T, et al. Torsade De Pointes Associated with Bradycardia and Takotsubo Cardiomyopathy. Can J Cardiol. 2008;24:640–42.
    1. Nault MA, Baranchuk A, Simpson CS, et al. Takotsubo Cardiomyopathy: A Novel “Proarrythmic” Disease. Anadolu Kardiyol Derg. 2007;(7 Suppl 1):101–3.
    1. Lalonde G, Beaulieu Y. Tako-Tsubo Cardiomyopathy. Can J Cardiol. 2005;21:1213–16.
    1. Lee WL, Miao LF, Chan HW, et al. Takotsubo Syndrome with Transient Complete Atrioventricular Block. Chin Med J. 2006;119:73–76.
    1. Nef HM, Möllmann H, Sperzel J, et al. Temporary Third-Degree Atrioventricular Block In A Case Of Apical Ballooning Syndrome. Int J Cardiol. 2006;113:e33–e35.
    1. Lyon AR, Rees PS, Prasad S, et al. Stress (Takotsubo) Cardiomyopathy-A Novel Pathophysiological Hypothesis to Explain Catecholamine-Induced Acute Myocardial Stunning. Nat Clin Pract Cardiovasc Med. 2008;5:22–29.
    1. Maruyama T, Hanaoka T, Nakajima H. Acute Pericarditis In The Recovery Phase Of Transient Left Ventricular Apical Ballooning Syndrome (Takotsubo Cardiomyopathy) Intern Med. 2007;46:1857–60.
    1. Akashi YJ, Tejima T, Sakurada H, et al. Left Ventricular Rupture Associated with Takotsubo Cardiomyopathy. Mayo Clin Proc. 2004;79:821–24.
    1. Ishida T, Yasu T, Arao K, et al. Images in Cardiovascular Medicine. Bedside Diagnosis of Cardiac Rupture by Contrast Echocardiography. Circulation. 2005;112:354–55.
    1. Ohara Y, Hiasa Y, Hosokawa S, et al. Left Ventricular Free Wall Rupture In Transient Left Ventricular Apical Ballooning. Circ J. 2005;69:621–23.
    1. Sacha J, Maselko J, Wester A, et al. Left Ventricular Apical Rupture Caused By Takotsubo Cardiomyopathy-Comprehensive Pathological Heart Investigation. Circ J. 2007;71:982–85.
    1. Chandrasegaram MD, Celermajer DS, Wilson MK. Apical Ballooning Syndrome Complicated By Acute Severe Mitral Regurgitation With Left Ventricular Outflow Obstruction-Case Report. J Cardiothorac Surg. 2007;2:1–4.
    1. Kurisu S, Inoue I, Kawagoe T, et al. Incidence and treatment of left ventricular apical thrombosis in Tako-tsubo cardiomyopathy. Int J Cardiol. 2011;146:e58–60.
    1. Sharkey SW, Shear W, Hodges M, et al. Reversible Myocardial Contraction Abnormalities in Patients with an Acute Noncardiac Illness. Chest. 1998;114:98–105.
    1. Prasad A, Lerman A, Rihal CS. Apical Ballooning Syndrome (Tako-Tsubo Or Stress Cardiomyopathy): A Mimic Of Acute Myocardial Infarction. Am Heart J. 2008;155:408–17.
    1. Kurisu S, Inoue I, Kawagoe T, et al. Documentation of Dynamic Electrocardiographic Changes Shortly After the Onset of Tako-Tsubo Cardiomyopathy. Int J Cardiol. 2007;119:258–60.
    1. Sankri-Tarbichi AG, Mathew PK, Matos M, et al. Stress-Related Cardiomyopathy. Heart Lung. 2007;36:43–46.
    1. Ito K, Sugihara H, Kawasaki T, et al. Assessment of Ampulla (Takotsubo) Cardiomyopathy with Coronary Angiography, Two-Dimensional Echocardiography and 99mTc-Tetrofosmin Myocardial Single Photon Emission Computed Tomography. Ann Nucl Med. 2001;15:351–55.
    1. Ogura R, Hiasa Y, Takahashi T, et al. Specific Findings of the Standard 12-Lead ECG in Patients with “Takotsubo” Cardiomyopathy: Comparison with the Findings of Acute Anterior Myocardial Infarction. Circ J. 2003;67:687–90.
    1. Sharkey SW, Lesser JR, Menon M, et al. Spectrum And Significance Of Electrocardiographic Patterns, Troponin Levels, And Thrombolysis In Myocardial Infarction Frame Count In Patients With Stress (Tako-Tsubo) Cardiomyopathy and Comparison To Those In Patients With ST-Elevation Anterior Wall Myocardial Infarction. Am J Cardiol. 2008;101:1723–28.
    1. Bybee KA, Motieti A, Syed IS, et al. Electrocardiography Cannot Reliably Differentiate Transient Left Ventricular Apical Ballooning Syndrome from Anterior ST-Segment Elevation Myocardial Infarction. J Electrocardiol. 2007;40:38e1–6.
    1. Maréchaux S, Fornes P, Petit S, et al. Pathology of Inverted Takotsubo Cardiomyopathy. Cardiovasc Pathol. 2008;17:241–43.
    1. Roongsritong C, Warraich I, Bradley C. Common Causes Of Troponin Elevations In The Absense Of Acute Myocardial Infarction: Incidence And Clinical Significance. Chest. 2004;125:1877–84.
    1. Apple FS, Quist HE, Doyle PJ, et al. Plasma 99th Percentile Reference Limits For Cardiac Troponin And Creatine Kinase MB Mass For Use With European Society Of Cardiology/American College Of Cardiology Consensus Recommendations. Clin Chem. 2003;49:1331–36.
    1. Madhavan M, Borlaug BA, Lerman A, et al. Stress hormone and circulating biomarker profile of apical ballooning syndrome (takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels. Heart. 2009;95:1436–41.
    1. Ferguson JL, Beckett GJ, Stoddart M, et al. Myocardial Infarction Redefined: The New ACC/ESC Definition, Based On Cardiac Troponin, Increases The Apparent Incidence Of Infarction. Heart. 2002;88:343–47.
    1. Tang WH, Francis GS, Morrow DA, et al. National Academy Of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization Of Cardiac Biomarker Testing In Heart Failure. Circulation. 2007;116:e99–109.
    1. Nef HM, Möllmann H, Weber M, et al. Release Pattern of Cardiac Biomarkers in Left Ventricular Apical Ballooning. Int J Cardiol. 2007;115:128–29.
    1. Pilgrim TM, Wyss TR. Takotsubo Cardiomyopathy or Transient Left Ventricular Apical Ballooning Syndrome: A Systematic Review. Int J Cardiol. 2008;124:283–92.
    1. Harris TB, Ferrucci L, Tracy RP, et al. Associations of Elevated Interleukin-6 and C-reactive protein Levels with Mortality in the Elderly. Am J Med. 1999;106:506–12.
    1. Dhoble A, Abdelmoneim SS, Bernier M, et al. Transient Left Ventricular Apical Ballooning And Exercise Induced Hypertension During Treadmill Exercise Testing: Is There A Common Hypersympathetic Mechanism? Cardiovasc Ultrasound. 2008;6:37.
    1. Marchionni N, Chechi T, Falai M, et al. Myocardial Stunning Associated With A Myocardial Bridge. Int J Cardiol. 2002;82:65–67.
    1. Metzl MD, Altman EJ, Spevack DM, et al. A Case of Takotsubo Cardiomyopathy Mimicking An Acute Coronary Syndrome. Nat Clin Pract Cardiovasc Med. 2006;3:53–56.
    1. Ohba Y, Takemoto M, Nakano M, et al. Takotsubo Cardiomyopathy with Left Ventricular Outflow Tract Obstruction. Int J Cardiol. 2006;107:120–22.
    1. Shah DP, Sugeng L, Goonewardena SN, et al. Images in Cardiovascular Medicine. Takotsubo Cardiomyopathy. Circulation. 2006;113:e762.
    1. Takizawa M, Kobayakawa N, Uozumi H, et al. A Case of Transient Left Ventricular Ballooning with Pheochromocytoma, Supporting Pathogenetic Role Of Catecholamines In Stress-Induced Cardiomyopathy Or Takotsubo Cardiomyopathy. Int J Cardiol. 2007;114:e15–17.
    1. Yasu T, Tone K, Kubo N, et al. Transient Mid-Ventricular Balloooning Cardiomyopathy: A New Entity of Takotsubo Cardiomyopathy. Int J Cardiol. 2006;110:100–1.
    1. Kumar S, Mostow N, Grimm RA. Quick Resolution of Takotsubo Cardiomyopathy: A Brief Review. Echocardiography. 2008;25:1117–20.
    1. Wani S, Glatz K, Suter Y, et al. “Apical Ballooning” – What Is The Cause? J Invasive Cardiol. 2008;20:599–602.
    1. Burri MV, Nanda NC, Lloyd SG, et al. Assessment Of Systolic And Diastolic Left Ventricular and Left Atrial Function Using Vector Velocity Imaging In Takotsubo Cardiomyopathy. Echocardiography. 2008;25:1138–44.
    1. Bahlmann E, Schneider C, Krause K, et al. Tako-Tsubo Cardiomyopathy (Apical Ballooning) With Parvovirus B19 Genome in Endomyocardial Biopsy. Int J Cardiol. 2007;116:e18–21.
    1. Núñez-Gil IJ, Fernández-Ortiz A, Pérez-Isla L, et al. Clinical and Prognostic Comparison between Left Ventricular Transient Dyskinesia and a First Non-ST-Segment Elevation Acute Coronary Syndrome. Coron Artery Dis. 2008;19:449–53.
    1. Hoyt J, Lerman A, Lennon R, et al. Left anterior descending artery length and coronary atherosclerosis in apical ballooning syndrome (takotsubo/stress induced cardiomyopathy) Int J Cardiol. 2010;145:112–15.
    1. Gianni M, Dentali F, Grandi AM, et al. Apical Ballooning Syndrome or Takotsubo Cardiomyopathy: A Systematic Review. Eur Heart J. 2006;27:1523–29.
    1. Tarkin JM, Khetyar M, Kaski JC. Management of Tako-Tsubo Syndrome. Cardiovasc Drugs Ther. 2008;22:71–77.
    1. Mitchell SA, Crone RA. Takotsubo Cardiomyopathy: A Case Report. J Am Soc Echocardiogr. 2006;19:1190.e9–10.
    1. Elesber AA, Prasad A, Bybee KA, et al. Transient Cardiac Apical Ballooning Syndrome: Prevalence and Clinical Implications of Right Ventricular Involvement. J Am Coll Cardiol. 2006;47:1082–83.
    1. Haghi D, Suselbeck T, Borggrefe M. Guidelines for Diagnosis of Takotsubo (Ampulla) Cardiomyopathy. Circ J. 2007;71:1664.
    1. Vallès E, Pujadas S, Guindo J, et al. Delayed-Contrast Enhancement Cardioresonance in Transient Left Ventricular Apical Ballooning. Int J Cardiovasc Imaging. 2007;23:243–47.
    1. Mahrholdt H, Goedecke C, Wagner A, et al. Cardiovascular Magnetic Resonance Assessment of Human Myocarditis: A Comparison to Histology and Molecular Pathology. Circulation. 2004;109:1250–58.
    1. Haghi D, Fluechter S, Suselbeck T, et al. Delayed Hyperenhancement In A Case Of Takotsubo Cardiomyopathy. J Cardiovasc Magn Reson. 2005;7:845–47.
    1. Kurisu S, Inoue I, Kawagoe T, et al. Myocardial Perfusion and Fatty Acid Metabolism in Patients with Tako-Tsubo-Like Ventricular Dysfunction. J Am Coll Cardiol. 2003;41:743–48.
    1. Uchida Y, Nanjo S, Fujimoto S, et al. Scintigraphic Studies on the Etiology of Ampulla Cardiomyopathy. J Cardiol. 2008;51:121–30.
    1. Ito K, Sugihara H, Kinoshita N, et al. Assessement of Takotsubo Cardiomyopathy (Transient Left Ventricular Apical Ballooning) Using 99mTc-Tetrosfosmin, 123I-BMIPP, 123I-MIBG and 99mTc-PYP Myocardial SPECT. Ann Nucl Med. 2005;19:435–45.
    1. Sato A, Aonuma K, Nozato T, et al. Stunned Myocardium in Transient Left Ventricular Apical Ballooning: A Serial Study of Dual I-123 BMIPP And Tl-201 SPECT. J Nucl Cardiol. 2008;15:671–79.
    1. Yilmaz Y. Apical Ballooning Syndrome: A Metabolic Form of Cardiomyopathy? Med Sci Monit. 2008;14(6):HY9–12.
    1. Obunai K, Misra D, Van Tosh A, et al. Metabolic Evidence of Myocardial Stunning In Takotsubo Cardiomyopathy: A Positron Emission Tomography Study. J Nucl Cardiol. 2005;12:742–44.
    1. Di Carli MF, Prcevski P, Singh TP, et al. Myocardial Blood Flow, Function, And Metabolism In Repetitive Stunning. J Nucl Med. 2000;41:1227–34.
    1. Dorbala S, Di Carli MF. Metabolic Imaging of Myocardial Stunning. Heart Metab. 2003;19:18–22.
    1. Nef HM, Möllamann H, Akashi J, et al. Mechanisms of stress (Takotsubo) cardiomyopathy. Nat Rev Cardiol. 2010;7:187–93.
    1. Stein AB, Tang XL, Guo Y, et al. Delayed Adaptation Of The Heart To Stress: Late Preconditioning. Stroke. 2004;35(11 Suppl 1):2676–79.
    1. Ueyama T, Kasamatsu K, Hano T, et al. Emotional Stress Induces Transient Left Ventricular Hypocontraction In The Rat Via Activation Of Cardiac Adrenoceptors: A Possible Animal Model Of “Tako-Tsubo” Cardiomyopathy. Circ J. 2002;66:712–13.
    1. Simoes MV, Marín-Neto JA, Maciel BC. Variable Regional Left Ventricular Dysfunction In Takotsubo Cardiomyopathy Syndrome. Echocardiography. 2007;24:893.
    1. Kawano H, Okada R, Yano K. Histological Study on the Distribution of Autonomic Nerves in the Human Heart. Heart Vessels. 2003;18:32–39.
    1. Kaski JC. Cardiac Syndrome X in Women: The Role of Oestrogen Deficiency. Heart. 2006;92(Suppl 3):iii5–9.
    1. Johnson BD, Shaw LJ, Buchthal SD, et al. Prognosis in Women with Myocardial Ischemia in the Absence of Obstructive Coronary Disease: Results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Circulation. 2004;109:2993–99.
    1. Demir H, Kahraman G, Isgoren S, et al. Evaluation Of Post-Stress Left Ventricular Dysfunction and its Relationship with Perfusion Abnormalities Using Gated SPECT in Patients With Cardiac Syndrome X. Nucl Med Commun. 2008;29:208–14.
    1. Ueyama T, Kasamatsu K, Hano T, et al. Catecholamines And Estrogen Are Involved In The Pathogenesis Of Emotional Stress-Induced Acute Heart Attack. Ann N Y Acad Sci. 2008;1148:479–85.
    1. Galiuto L, De Caterina AR, Porfidia A, et al. Reversible coronary microvascular dysfunction: a common pathogenetic mechanism in apical balloning or tako-tsubo syndrome. Eur Heart J. 2010;31:1319–27.
    1. Bielecka-Dabrowa A, Mikhailidis DP, Hannam S, et al. Takotsubo cardiomyopathy-The current state of knowledge. Int J Cardiol. 2010;142:120–25.
    1. Page SP, Pantazis A, Elliott PM. Acute Myocardial Ischemia Associated with Latent Left Ventricular Outflow Tract Obstruction in the Absence of Left Ventricular Hypertrophy. J Am Soc Echocardiog. 2007;20:772.e1–4.
    1. Thorne KD, Kerut EK, Moore CK. Apical Ballooning “Tako-Tsubo” Syndrome Associated with Transient Left Ventricular Outflow Tract Obstruction. Echocardiography. 2007;24:770–72.
    1. Peñas-Lado M, Barriales-Villa R, Goicolea J. Transient Left Ventricular Apical Ballooning and Outflow Tract Obstruction. J Am Coll Cardiol. 2003;42:1143–44.
    1. Makaryus AN, Meraj P, Rosman D. Dynamic Left Ventricular Outflow Tract Obstruction Induced By Dobutamine Stress Echocardiography Leading To Myocardial Ischemia And Infarction. Int J Cardiovasc Imaging. 2006;22:763–69.
    1. Krasnow N. Subaortic Septal Bulge Simulates Hypertrophic Cardiomyopathy By Angulation Of The Septum with Age, Independent Of Focal Hypertrophy. An Echocardiographic Study. J Am Soc Echocardiogr. 1997;10:545–55.
    1. Previtali M, Repetto A, Scuteri L. Dobutamine Induced Severe Midventricular Obstruction and Mitral Regurgitation in Left Ventricular Apical Ballooning Syndrome. Heart. 2005;91:353.
    1. Cabrera-Bueno F, Gómez-Doblas JJ, Muñoz-García A, et al. Effort Angina, Normal Coronary Angiogram, and Dynamic Left Ventricular Obstruction. J Am Soc Echocardiogr. 2007;20:415–20.
    1. Desmet W. Dynamic LV Obstruction in Apical Ballooning Syndrome: The Chicken or the Egg. Eur J Echocardiogr. 2006;7:1–4.
    1. Ibáñez B, Navarro F, Córdoba M, et al. Tako-Tsubo Transient Left Ventricular Apical Ballooning: Is Intravascular Ultrasound The Key To Resolve The Enigma? Heart. 2005;91:102–4.
    1. Ibánez B, Navarro F, Farré J, et al. Tako-tsubo syndrome associated with a long course of the left anterior descending coronary artery along the apical diaphragmatic surface of the left ventricle. Rev Esp Cardiol. 2004;57:209–216. [in Spanish with English abstract]
    1. Pison L, De Vusser P, Mullens W. Apical Ballooning in Relatives. Heart. 2004;90:e67.
    1. Sharkey SW, Maron BJ, Nelson P, et al. Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy. J Cardiol. 2009;53:53–57.
    1. Cortese B, Robotti S, Puggioni E, et al. Transient Left Ventricular Apical Ballooning Syndrome: All That Glitters Is Not Apical. J Cardiovasc Med. 2007;8:934–36.
    1. Kurowski V, Kaiser A, Von Hof K, et al. Apical And Midventricular Transient Left Ventricular Dysfunction Syndrome (Tako-Tsubo Cardiomyopathy): Frequency, Mechanisms, And Prognosis. Chest. 2007;132:809–16.
    1. Yoshioka T, Hashimoto A, Tsuchihashi K, et al. Clinical Implications Of Midventricular Obstruction And Intravenous Propanolol Use In Transient Left Ventricular Apical Ballooning (Tako-Tsubo Cardiomyopathy) Am Heart J. 2008;155:526e1–7.
    1. Nyui N, Yamanaka O, Nakayama R, et al. “Tako-Tsubo” Transient Ventricular Dysfunction: A case report. Jpn Circ J. 2000;64:715–19.
    1. Song ZZ, Ma J. Right Ventricular Involvement in Takotsubo Cardiomyopathy. Eur Heart J. 2007;28:1037–38.
    1. López-Candales A, Rajagopalan N, Saxena N, et al. Right Ventricular Systolic Function Is Not The Sole Determinant Of Tricuspid Annular Motion. Am J Cardiol. 2006;98:973–77.
    1. Haghi D, Suselbeck T, Poerner T, et al. A Novel Regional Right Ventricular Wall-Motion Abnormality Observed in a Case of Acute Pulmonary Embolism (Reverse McConnell Sign) J Am Soc Echocardiogr. 2005;18:75–77.
    1. Haghi D, Athanasiadis A, Papavassiliu T, et al. Right ventricular involvement in Takotsubo cardiomyopathy. Eur Heart J. 2006;27:2433–39.
    1. Padayachee L. Levosimendan: The Inotrope of Choice in Cardiogenic Shock Secondary to Takotsubo Cardiomyopathy? Heart, Lung and Circulation. 2007;16(Suppl 3):S65–70.
    1. Abu-Fanne R, Rott D, Klein M, et al. Recurrent Apical Ballooning Despite Treatment With Verapamil. Cardiology. 2007;108:210–13.
    1. Ueyama T, Hano T, Kasamatsu K, et al. Estrogen Attenuates The Emocional Stress-Induced Cardiac Response In The Animal Model Of Tako-Tsubo (Ampulla) Cardiomyopathy. J Cardiovasc Pharmacol. 2003;42(Suppl 1):S117–19.
    1. Hale SL, Kloner RA. Ranolazine, An Inhibitor Of The Late Sodium Channel Current, Reduces Postischemic Myocardial Dysfunction In The Rabbit. J Cardiovasc Pharmacol Ther. 2006;11:249–55.
    1. Abdulla I, Ward MR. Tako-Tsubo Cardiomyopathy: How Stress Can Mimic Acute Coronary Occlusion. Med J Aust. 2007;187:357–60.
    1. Sharkey SW, Windenburg DC, Lesser JR, et al. Natural history and expansive clinical profile of stress (Tako-Tsubo) cardiomyopathy. J Am Coll Cardiol. 2010;55:333–41.
    1. Park JH, Kang SJ, Song JK, et al. Left Ventricular Apical Ballooning Due To Severe Physical Stress In Patients Admitted To The Medical ICU. Chest. 2005;128:296–302.
    1. Haghi D, Fluechter S, Suselbeck T, et al. Takotsubo Cardiomyopathy (Acute Left Ventricular Apical Ballooning Syndrome) Occurring In The Intensive Care Unit. Intensive Care Med. 2006;32:1069–74.
    1. Ruiz-Bailén M, Aguayo de Hoyos E, Ruiz-Navarro S, et al. Reversible myocardial dysfunction after cardiopulmonary resuscitation. Resuscitation. 2005;66:175–81.
    1. Chockalingam A, Mehra A, Dorairajan S, et al. Acute left ventricular dysfunction in the critically ill. Chest. 2010;138:198–207.
    1. Vydt T, Dubois C, Papas C, et al. Once Apical Ballooning, Always Apical Ballooning? Int J Cardiol. 2008;127:e132–33.
    1. Barcin C, Kursaklioglu H, Kose S, et al. Takotsubo Cardiomyopathy In A Patient With Addison Disease: Is Apical Ballooning Always Reversible? Int J Cardiol. 2010;138:e15–17.
    1. Previtali M, Repetto A, Camporotondo R, et al. Clinical characteristics and outcome of left ventricular ballooning syndrome in a European population. Am J Cardiol. 2011;107:120–25.
    1. Ruiz-Bailén M, Romero-Bermejo FJ, Rucabado-Aguilar L, et al. Myocardial dysfunction in the critically ill patient: Is it really reversible? Int J Cardiol. 2010;145(3):615–16.

Source: PubMed

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