Comment on "The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients"
Fatiha Chigr, Mohamed Merzouki, Mohamed Najimi, Fatiha Chigr, Mohamed Merzouki, Mohamed Najimi
Abstract
We have read with great care and interest the article by Li et al The authors provide interesting elements with respect to the possible entry of severe acute respiratory syndrome coronavirus 2 at the brain area and plead for an implication of the central nervous system in respiratory problems linked to coronavirus disease. Here we provide additional elements that support those observations, notably the role of brainstem structures located in the medulla oblongata in modulating respiration. We also discussed the possible pathways the virus uses to cross the brain blood barrier and reach the brainstem.
Keywords: COVID-19; central nervous system; coronavirus; respiratory tract.
Conflict of interest statement
The authors declare that there are no conflict of interests.
© 2020 Wiley Periodicals LLC.
References
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Source: PubMed